全文获取类型
收费全文 | 334篇 |
免费 | 12篇 |
出版年
2023年 | 5篇 |
2022年 | 4篇 |
2021年 | 5篇 |
2020年 | 3篇 |
2019年 | 4篇 |
2018年 | 4篇 |
2017年 | 7篇 |
2016年 | 3篇 |
2015年 | 8篇 |
2014年 | 11篇 |
2013年 | 12篇 |
2012年 | 10篇 |
2011年 | 10篇 |
2010年 | 8篇 |
2009年 | 5篇 |
2008年 | 18篇 |
2007年 | 9篇 |
2006年 | 8篇 |
2005年 | 9篇 |
2004年 | 8篇 |
2003年 | 6篇 |
2001年 | 2篇 |
2000年 | 5篇 |
1999年 | 7篇 |
1998年 | 2篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 4篇 |
1994年 | 14篇 |
1993年 | 8篇 |
1992年 | 3篇 |
1991年 | 9篇 |
1990年 | 9篇 |
1989年 | 9篇 |
1988年 | 7篇 |
1987年 | 9篇 |
1986年 | 5篇 |
1985年 | 9篇 |
1984年 | 6篇 |
1983年 | 9篇 |
1982年 | 14篇 |
1981年 | 8篇 |
1980年 | 10篇 |
1978年 | 2篇 |
1976年 | 5篇 |
1975年 | 1篇 |
1974年 | 3篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1971年 | 4篇 |
排序方式: 共有346条查询结果,搜索用时 932 毫秒
41.
Sandra L. Tanner Elaine E. Storm †‡ George D. Bittner 《Journal of neurochemistry》1995,64(4):1491-1501
Abstract: Using video-enhanced microscopy and a pulse-radiolabeling paradigm, we show that proteins synthesized in the medial giant axon cell body of the crayfish ( Procambarus clarkii ) are delivered to the axon via fast (∼62 mm/day) and slow (∼0.8 mm/day) transport components. These data confirm that the medial giant axon cell body provides protein to the axon in a manner similar to that reported for mammalian axons. Unlike mammalian axons, the distal (anucleate) portion of a medial giant axon remains intact and functional for >7 months after severance. This axonal viability persists long after fast transport has ceased and after the slow wave front of radiolabeled protein has reached the terminals. These data are consistent with the hypothesis that another source (i.e., local glial cells) provides a significant amount of protein to supplement that delivered to the medial giant axon by its cell body. 相似文献
42.
Neurofilament Proteins Are Distributed in a Diminishing Proximodistal Gradient Along Rat Sciatic Nerve 总被引:3,自引:2,他引:1
Neurofilament (NF) proteins are distributed in a diminishing proximodistal gradient along rat sciatic nerve when compared with total noncollagen or other proteins in nerve. About a twofold decline of NF proteins can be detected by quantitating nerve proteins that have been separated by gel electrophoresis. A similar decrease of immunoreactivity to each NF subunit is seen in distal nerve segments when noncollagen nerve proteins are immunoblotted. Parallel decreases occur in all three NF proteins, thereby maintaining neurofilament subunit stoichiometry along the neuraxis. The same NF gradient can be detected when the NF contents in nerve branches to the gluteus and gastrocnemius muscles are compared with each other and with those in nerve segments taken from the same proximodistal levels of the parent sciatic nerve. The gradient of NF proteins increases during postnatal development and is readily detected by postnatal day 16. During the same period of development, the heavy NF subunit appears for the first time and is rapidly incorporated throughout the sciatic nerve. Hence, the NF gradient becomes manifest during the development and maturation of the adult form of the axonal cytoskeleton. The basis for the proximodistal gradient of NF proteins in peripheral nerve is presently unknown. The extent of the gradient cannot be accounted for on the basis of diminishing numbers of nerve fibers or increasing amounts of other nerve proteins, e.g., collagen, in distal nerve. An alternative interpretation is that the gradient reflects a low level of NF protein turnover during axonal transport. 相似文献
43.
Judy A. Garner 《Journal of neurochemistry》1990,54(5):1700-1708
Rises in intracellular calcium cause several events of physiological significance, including the regulated release of neuronal transmitters. In this study, the effects of divalent cations on the structural organization of cytomatrix in presynaptic terminals was examined. [35S]Methionine-radiolabeled guinea pig retinal ganglion cell cytomatrix proteins were axonally transported [in slow component b (SCb) of axonal transport] to the neuron terminals in the superior colliculus. When the peak of radiolabeled cytomatrix proteins reached the terminals, synaptosomes containing the radiolabeled cytomatrix proteins were prepared. Approximately 40% of each SCb protein was soluble after hypoosmotic lysis of the radiolabeled synaptosomes in the presence of divalent cation chelators. Lysis of synaptosomes in the presence of calcium ions over a range of concentrations, however, caused a dramatic decrease in solubility of the presynaptic SCb proteins. The cytoplasmic effects may result from a calcium-dependent condensation of cytoplasm around presynaptic terminal membrane systems. There are two major presynaptic SCb proteins (at 60 and 35 kDa), that exhibited exceptional behavior: they remained as soluble in the presence of calcium as under control conditions, suggesting that they were relatively unaffected by the mechanism causing the decrease in SCb protein solubility. Also examined were the effects of other alkaline earth and transition metal divalent cations on the presynaptic SCb proteins. 相似文献
44.
Summary The effects of chlorpromazine (cpz) and tetracaine (tc) on the rapid axonal transport of neurosecretory material (NSM) in the hypothalamo-neurohypophysial system was investigated. Following subarachnoidal injection of these drugs, the incorporation of (35S) cysteine into proteins of the supraoptic nucleus was slightly depressed. The protein-bound radioactivity in the posterior pituitary was markedly lowered in experimental rats which indicates a partial blockage of the rapid axonal transport of NSM along the hypothalamoneurohypophysial tract. Both cpz and tc induced an increase in the number of mitochondria and profiles of granular endoplasmic reticulum. The axons in the infundibulum and neurohypophysis were enlarged by dammed organelles, indicating a blockage of axonal transport. There was an increased number of microvesicles, often arranged in a crystalloid pattern, in the terminals. The number and distribution of neurotubuli and neurofilaments were not changed. A possible stimulatory effect of cpz on the release of NSM from the neural lobe is assumed Possible mechanisms for the action of mitotic inhibitors, transquilizers and local anesthetics are discussed.The present work was supported by grants from Svenska Livforsäkringsbolags Fond, H. Hiertas stiftelse, Magnus Bergwalls stiftelse, The Swedish Medical Research Council No. B73-12X-2543-05B, Statens naturvetenskapliga forskningsråd No. 2535-8 and from the Medical Faculty, University of Göteborg. We are indebted to Mrs. Margareta Andersson, Mrs. Wally Holmberg, Mrs. Elisabeth Norström and Mrs. Ulla Svedin for excellent technical assistance, and to Miss Gull Grönstedt for careful secretarial work. 相似文献
45.
46.
Iterative ontogenetic development of ammonoid conch shapes from the Devonian through to the Jurassic
下载免费PDF全文
![点击此处可从《Palaeontology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
We measured longitudinal growth in conch cross‐sections of 177 Devonian to Jurassic ammonoid species to test whether conch ontogenetic development parallels the iterative evolution of pachyconic or globular conch shapes. Ontogenetic trajectories of two cardinal conch parameters, conch width index and umbilical width index, show a few common recurring ontogenetic pathways in terms of the number of ontogenetic phases. The most common, with three phases in the conch width index (decrease–increase–decrease) and umbilical width index (increase–decrease–increase), is termed here C‐mode ontogeny (after the Carboniferous genus Cravenoceras). Many of the studied globular Palaeozoic and Triassic species (of the latter, particularly the arcestid ammonoids) share principal patterns in the triphasic C‐mode conch ontogeny in closely related groups but also between unrelated groups as well. The repetition of conch growth patterns is an example of convergent evolution of the entire life history of globular ammonoids. The studied Jurassic globular shaped ammonoids deviate from the growth patterns seen in earlier groups showing less pronounced ontogenetic trajectories with nearly isometric or weakly asymmetric growth without distinct phases. This trajectory is termed here M‐mode ontogeny (after the Jurassic genus Macrocephalites). No major change in the ontogenetic modes of pachyconic and globular ammonoids occurred moving from the Palaeozoic into the Mesozoic; the survivors of the end‐Permian extinction event iteratively developed conch ontogenies similar to those of Palaeozoic forms. In contrast, the Triassic–Jurassic boundary marks the major event with the evolution of some cardinal conch parameters relating to globular ammonoid ontogeny. 相似文献
47.
Sid Staubach Peter Schützner Roger P. Croll Annette Klussmann-Kolb 《Zoomorphology》2008,127(4):203-212
This study describes the innervation patterns for the cerebral nerves which project to the cephalic sensory organs (CSOs)
in the opisthobranch Haminoea hydatis (Linnaeus 1758) and uses axonal tracing techniques (backfilling) to reveal the central cellular origins for these cerebral
nerves. Cell clusters projecting into the cerebral nerves can be defined by their positions in the ganglion relative to other
clusters, nerve roots and lobes. The number of cell clusters and the relative sizes of somata are constant in a given cluster,
whereas the absolute number of somata and absolute sizes of single somata in a given cluster increase with the size of the
animal. Additionally, the invariable morphological characteristics of the cell clusters are used to define criteria for the
assessment of possible homology for the clusters innervating the CSOs in Opisthobranchia. The data suggest two different strategies
to accommodate the increasing body size; first, the additions of nerve cells and second, the growth of nerve cells.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
48.
The distribution of morphological structures was studied in wings of the banded agrion (Calopteryx splendens Harr.) from different intrapopulation groups. Dragon flies of odd years of emergence are characterized by a more stable pattern of ontogenetic processes according to the mean total number of venation defects. The sharply increased level of radiation in summer 1986, which coincided with the flight of dragon-flies, could have caused hereditary defects expressed in a sequence of generations of even years of emergence. Apparently, most alternative features of wing venation in dragon-flies can be considered as markers of stability of the ontogenetic processes, which reflect, to a great extent, genotypic features of the organisms in a population. A possible mechanism has been described, which explains the proposed topological model of formation of the venation defects of different types. The increase in mean frequencies of defects can suggest an enhanced development over the aberrant epigenetic trajectories, which may lead to the elimination of these organisms under the influence of various agents, i.e., to the stabilizing selection in a population. The results obtained suggest that defects of venation arise on the stochastic basis and their frequency increases upon destabilization of ontogenetic processes not only by the environmental factors, but also by genetic stress. Venation defects can be successfully used in population biomonitoring. 相似文献
49.
Chemosensory neurons in the olfactory epithelium (OE) project axonal processes to the olfactory bulb (OB) of the brain. During
embryonic stages, on their trajectory to the OB, the outgrowing axons traverse the so-called cribriform mesenchyme, which
is located between the OE and the OB. The molecular cues guiding these axons through the cribriform mesenchyme are largely
unknown. To identify molecules influencing the axonal trajectory in the murine cribriform mesenchyme, we performed microarray
analyses focusing on extracellular matrix (ECM) proteins present in this tissue. Thereby, the ECM protein Reelin turned out
to be an interesting candidate. Reelin was found to be expressed by numerous cells in the cribriform mesenchyme during the
embryonic stages when the first axons navigate from the OE to the OB. These cells were closely associated with olfactory axons
and apparently lack glial and neuronal markers. In the mesenchyme underlying the OE, localization of the Reelin protein was
not confined to the Reelin-expressing cells, but it was also observed to be widely distributed in the ECM—most prominently
in regions traversed by olfactory axons. Importantly, these axons were found to be endowed with the Reelin receptor very-low-density
lipoprotein receptor (VLDLR). Finally, Reelin expression was also detectable in neuronal cells of the OB, which are contacted
by VLDLR-positive olfactory axons. In summary, the results of the present study suggest that a Reelin/VLDLR signaling pathway
might contribute to the formation of olfactory projections to the OB and the establishment of initial contacts between the
incoming axons and neurons in the OB.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Funding: This work was supported by the Deutsche Forschungsgemeinschaft. 相似文献
50.
The temperature–frequency relationship in nerve conduction block induced by high-frequency, biphasic electrical current was
investigated by computer simulation using an amphibian myelinated axon model based on Frankenhaeuser–Huxley (FH) equations.
For an axon of diameter 10 μm, the minimal blocking frequency was changed from 6 to 3 kHz as the temperature was decreased
from 37°C to 15°C. The maximal blocking temperature below which the axon could be blocked was increased from 22°C to 37°C
as the stimulation frequency was increased from 4 to 8 kHz. The maximal blocking temperature was not influenced by axon diameter.
Simulation analysis also revealed that activation of potassium channels might determine the temperature–frequency relationship.
This study indicates that temperature might be one of the factors that cause the frequency discrepancy as reported in previous
animal studies.
Action Editor: Alain Destexhe 相似文献