全文获取类型
收费全文 | 260篇 |
免费 | 5篇 |
国内免费 | 12篇 |
出版年
2023年 | 6篇 |
2022年 | 8篇 |
2021年 | 1篇 |
2020年 | 2篇 |
2019年 | 5篇 |
2018年 | 4篇 |
2017年 | 2篇 |
2016年 | 7篇 |
2015年 | 7篇 |
2014年 | 8篇 |
2013年 | 11篇 |
2012年 | 10篇 |
2011年 | 59篇 |
2010年 | 9篇 |
2009年 | 11篇 |
2008年 | 8篇 |
2007年 | 8篇 |
2006年 | 11篇 |
2005年 | 15篇 |
2004年 | 6篇 |
2003年 | 9篇 |
2002年 | 6篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 7篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1983年 | 4篇 |
1982年 | 1篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1976年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有277条查询结果,搜索用时 15 毫秒
271.
《Current biology : CB》2022,32(16):3609-3618.e7
- Download : Download high-res image (127KB)
- Download : Download full-size image
272.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin cancer with a tobacco consumption and infection with high-risk human papillomavirus (HPV) being major risk factors. Despite advances in numerous therapy modalities, survival rates for HNSCC have not improved considerably; a vast number of clinical outcomes have demonstrated that a combination strategy (the most well-known docetaxel, cisplatin, and 5-fluorouracil) is the most effective treatment choice. Immunotherapy that targets immunological checkpoints is being tested in a number of clinical trials, either alone or in conjunction with chemotherapeutic or targeted therapeutic drugs. Various monoclonal antibodies, such as cetuximab and bevacizumab, which target the EGFR and VEGFR, respectively, as well as other signaling pathway inhibitors, such as temsirolimus and rapamycin, are also being studied for the treatment of HNSCC. We have reviewed the primary targets in active clinical studies in this study, with a particular focus on the medications and drug targets used. 相似文献
273.
Bradlee L. Heckmann Xiaodong ZhangXitao Xie Jun Liu 《Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids》2013,1831(2):276-281
The G0/G1 switch gene 2 (G0S2) was originally identified in blood mononuclear cells following induced cell cycle progression. Translation of G0S2 results in a small basic protein of 103 amino acids in size. It was initially believed that G0S2 mediates re-entry of cells from the G0 to G1 phase of the cell cycle. Recent studies have begun to reveal the functional aspects of G0S2 and its protein product in various cellular settings. To date the best-known function of G0S2 is its direct inhibitory capacity on the rate-limiting lipolytic enzyme adipose triglyceride lipase (ATGL). Other studies have illustrated key features of G0S2 including sub-cellular localization, expression profiles and regulation, and possible functions in cellular proliferation and differentiation. In this review we present the current knowledge base regarding all facets of G0S2, and pose a variety of questions and hypotheses pertaining to future research directions. 相似文献
274.
275.
276.
Embryogenesis of peripheral nerve pathways in grasshopper legs. III. Development without pioneer neurons 总被引:2,自引:0,他引:2
We have examined the consequence of deleting the first pathfinding neurons to differentiate in the metathoracic leg, cell pair tibial 1 (Ti1) (C. M. Bate, 1976, Nature (London) 260, 54-56; H. Keshishian, 1980, Dev. Biol. 80, 388-397) on the development of two uniquely identifiable follower sensory neurons, and upon the subsequent development of nerve 5B1 in the leg. Following the equivalent of 10-15% of embryonic development in culture the follower sensory neurons were found to have formed topologically normal axonal trajectories in the leg, and to have established contacts with later differentiating sensory and motor axons in an essentially normal fashion. The results show that followers can navigate the route normally taken by the pioneers, and suggest that the pioneers do not have unusual pathfinding capabilities. 相似文献
277.
Bok Yeop Ahn Steven B. Walker Scott C. Slimmer Analisa Russo Ashley Gupta Steve Kranz Eric B. Duoss Thomas F. Malkowski Jennifer A. Lewis 《Journal of visualized experiments : JoVE》2011,(58)
Printed electronics rely on low-cost, large-area fabrication routes to create flexible or multidimensional electronic, optoelectronic, and biomedical devices1-3. In this paper, we focus on one- (1D), two- (2D), and three-dimensional (3D) printing of conductive metallic inks in the form of flexible, stretchable, and spanning microelectrodes.Direct-write assembly4,5 is a 1-to-3D printing technique that enables the fabrication of features ranging from simple lines to complex structures by the deposition of concentrated inks through fine nozzles (~0.1 - 250 μm). This printing method consists of a computer-controlled 3-axis translation stage, an ink reservoir and nozzle, and 10x telescopic lens for visualization. Unlike inkjet printing, a droplet-based process, direct-write assembly involves the extrusion of ink filaments either in- or out-of-plane. The printed filaments typically conform to the nozzle size. Hence, microscale features (< 1 μm) can be patterned and assembled into larger arrays and multidimensional architectures.In this paper, we first synthesize a highly concentrated silver nanoparticle ink for planar and 3D printing via direct-write assembly. Next, a standard protocol for printing microelectrodes in multidimensional motifs is demonstrated. Finally, applications of printed microelectrodes for electrically small antennas, solar cells, and light-emitting diodes are highlighted. 相似文献