论网络环境下图书馆多元化服务与创新

互联网的迅速普及,数字化图书馆也已经逐渐普及,网络也拓宽了图书馆的信息服务渠道,各图书馆之间实现了资源共享的同时也为广大读者提供了更广泛的信息资源。因此带来了图书馆服务工作的变化和创新,以信息和知识检索、收集、传播发布为主的多功能服务发生转变,图书馆走向了多元化服务阶段。     

维吾尔药神香草调节哮喘大鼠下丘脑-垂体-肾上腺轴功能紊乱的实验研究

目的：观察维吾尔药（维药）神香草对哮喘大鼠模型神经内分泌免疫网络若干组分的影响。方法：取雄性健康Wistar大鼠50只,随机分为正常对照组,哮喘模型组,神香草低、中、高剂量治疗组。采用致敏和雾化的方法制备哮喘模型。采用酶联免疫吸附试验（ELISA）方法检测血清中白介素-4（IL^4）、白介素-6（IL-6）、干扰素-γ（IFN-γ）、皮质酮（CORT）水平;放免法检测血浆中促肾上腺皮质激素（ACTH）的含量;采用实时定量-聚合酶链反应（RT—PCR）法测定下丘脑促肾上腺皮质激素释放激素（CRH）mRNA表达水平。结果：哮喘反复发作时,大鼠下丘脑-垂体-肾上腺（HPA）轴紊乱,哮喘大鼠下丘脑CRHmRNA表达和血浆ACTH无明显变化,实验各组血清CORT水平升高（P〈0．05）,神香草高剂量组血清CORT含量高于低剂量组（P〈0．05）。细胞因子IFN-γ无明显变化,IL-6、IL-4有下降趋势（P〈0．05）。结论：哮喘反复发作的大鼠存在NEI网络的紊乱;神香草可以增强下丘脑．垂体．肾上腺皮质（HPA）轴的功能,改善细胞因子的平衡。这些可能是其治疗哮喘的机制之一。     

Coevolution study of mitochondria respiratory chain proteins: toward the understanding of protein--protein interaction

Coevolution can be seen as the interdependency between evolutionary histories. In the context of protein evolution, functional correlation proteins are ever-present coordinated evolutionary characters without disruption of organismal integrity. As to complex system, there are two forms of protein-protein interactions in vivo, which refer to inter-complex interaction and intra-complex interaction. In this paper, we studied the difference of coevolution characters between inter-complex interaction and intra-complex interaction using "Mirror tree" method on the respiratory chain (RC) proteins. We divided the correlation coefficients of every pairwise RC proteins into two groups corresponding to the binary protein-protein interaction in intra-complex and the binary protein-protein interaction in inter-complex, respectively. A dramatical discrepancy is detected between the coevolution characters of the two sets of protein interactions (Wilcoxon test, p-value = 4.4 x 10-6). Our finding reveals some critical information on coevolutionary study and assists the mechanical investigation of protein-protein interaction.Furthermore, the results also provide some unique clue for supramolecular organization of protein complexes in the mitochondrial inner membrane. More detailed binding sites map and genome information of nuclear encoded RC proteins will be extraordinary valuable for the further mitochondria dynamics study.     

转基因花粉能飘多远

最近，美国普林斯顿大学的工程师利用细菌相互之间的作用产生出有规律的颜色编码--这向研制细菌计算机迈出了重要的一步。     

网络环境下的期刊服务工作

分析了高校图书馆在网络环境下期刊服务工作的特点,论述了提高期刊服务工作质量(?)体措施——调整期刊资源的结构,重视文献的开发利用,深化期刊信息服务工作,加强馆际协(?)促进资源共享,增强用户的网络信息意识和能力及提高馆员的素质。     

PHProteomicDB： A Module for Two-dimensional Gel Electrophoresis Database Creation on Personal Web Sites

PHProteomicDB is a PHP-written module to help researchers in proteomics to share two-dimenslonal gel electrophoresis data using personal web sites. No technical or PHP knowledge is necessary except a few basics about web site management. PHProteomicDB has a user-friendly administration interface to enter and update data. It creates web pages on the fly displaying gel characteristics, gel pictures, and numbered gel spots with their related identifications pointing to their reference pages in protein databanks. The module is freely available at http：//www.huvec.com/index.php3？rub=Download.     

防治禽流感特异性免疫球蛋白值得关注

中国工程院院士、军事医科院军事兽医研究所研究员夏咸柱近日表示,疫苗是禽流感最有效的预防方法,但由于病毒抗体漂移引起病毒的变异,生产应对当前流行株的疫苗至少需要4个月,这当然也包括H5N1抗原变异株。因此,在流感大流行的早期阶段应用抗病毒药物有助于控制疫情。WHO正准备利用现有的流感实验室网络,建立测定抗病毒药物敏感性检测机制,我国更有必要对国内的H5N1禽流感病毒株进行药物筛选与调查,为药物储备提供参考。