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排序方式: 共有610条查询结果,搜索用时 15 毫秒
71.
浮舰蛋白(flotillin)是细胞膜上一类高度保守的脂筏标记蛋白,且广泛存在于体内不同的组织和细胞.浮舰蛋白在细胞信号转导、细胞黏附、细胞骨架重构、胞吞等生物过程中发挥重要作用. 近年研究发现,浮舰蛋白-1( flotillin-1)与肿瘤的发生、发展及转移关系密切.本文就浮舰蛋白-1在恶性肿瘤中的研究现状做一综述,旨在为进一步研究浮舰蛋白-1与恶性肿瘤发病机制的关系及作为治疗的靶标提供参考. 相似文献
72.
正植物的衰老受发育年龄和体内信号因子精确调节。脱落酸(ABA)是植物五大激素之一,参与众多的生物学过程,如促进种子休眠、提高耐逆性、调节气孔开关、促进叶片衰老等。在植物衰老时,体内ABA含量急剧升高,外源ABA也可诱导叶片衰老,因此,ABA被认为是一重要的衰老促进激素。然而,水稻中ABA合成和信号传导相关基因的突变体并未表现出延迟衰老的表型。因此,人们一直困惑ABA是如何参与调控植物的衰老进程。 相似文献
73.
《植物生理与分子生物学学报》2014,(6):939-942
Ethylene, a gaseous plant hormone, plays critical roles in plant growth, development, and response to environment. Ethylene-regulated processes are initiated by the elevation of ethylene biosynthesis, which is under tight control by a complex signaling network. An elevated level of ethyl- ene is then perceived by ethylene receptors in local and neighboring cells, which activates signaling pathways that lead to ethylene responses. Different types of tissues/cells have differential capacities in producing ethylene and dif- ferential sensitivity to ethylene, which are crucial to the diverse functions of ethylene in plants. This report high- lights recent advances in our understanding of kinases and phosphatases in ethylene biosynthesis and signaling. 相似文献
74.
Sophia Ng ;Inge De Clercqc ;Olivier Van Akena ;Simon R. Lawd ;Aneta Ivanovad ;Patrick Willems ;Estelle Giraud ;Frank Van Breusegem ;James Wheland 《植物生理与分子生物学学报》2014,(7):1075-1093
Mitochondrial biogenesis and function in plants require the expression of over 1000 nuclear genes encoding mitochondrial proteins (NGEMPs). The expression of these genes is regulated by tissue-specific, developmental, internal, and external stimuli that result in a dynamic organelle involved in both metabolic and a variety of signaling processes. Although the metabolic and biosynthetic machinery of mitochondria is relatively well understood, the factors that regu- late these processes and the various signaling pathways involved are only beginning to be identified at a molecular level. The molecular components of anterograde (nuclear to mitochondrial) and retrograde (mitochondrial to nuclear) signaling pathways that regulate the expression of NGEMPs interact with chloroplast-, growth-, and stress-signaling pathways in the cell at a variety of levels, with common components involved in transmission and execution of these signals. This positions mitochondria as important hubs for signaling in the cell, not only in direct signaling of mitochondrial function per se, but also in sensing and/or integrating a variety of other internal and external signals. This integrates and optimizes growth with energy metabolism and stress responses, which is required in both photosynthetic and non-photosynthetic cells. 相似文献
75.
Rainer E. Haiusler ;Luisa Heinrichs ;Jessica Schmitz ;Ulf-Ingo Flugge 《植物生理与分子生物学学报》2014,(7):1121-1137
The concept of retrograde control of nuclear gene expression assumes the generation of signals inside the chloroplasts, which are either released from or sensed inside of the organelle. In both cases, downstream signaling path- ways lead eventually to a differential regulation of nuclear gene expression and the production of proteins required in the chloroplast. This concept appears reasonable as the majority of the over 3000 predicted plastidial proteins are encoded by nuclear genes. Hence, the nucleus needs information on the status of the chloroplasts, such as during acclimation responses, which trigger massive changes in the protein composition of the thylakoid membrane and in the stroma. Here, we propose an additional control mechanism of nuclear- and plastome-encoded photosynthesis genes, taking advantage of pathways involved in sugar- or hormonal signaling. Sugars are major end products of photosynthesis and their con- tents respond very sensitively to changes in light intensities. Based on recent findings, we ask the question as to whether the carbohydrate status outside the chloroplast can be directly sensed within the chloroplast stroma. Sugars might syn- chronize the responsiveness of both genomes and thereby help to coordinate the expression of piastome- and nuclear- encoded photosynthesis genes in concert with other, more specific retrograde signals. 相似文献
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77.
钙调神经磷酸酶的研究进展 总被引:8,自引:0,他引:8
钙调神经磷酸酶(CaN)是一种受Ca2+/钙调素调节的丝/苏氨酸蛋白磷酸酶,广泛存在于哺乳动物的组织细胞中,作为Ca2+信号下游的一种效应分子,参与多种细胞功能的调节.在T细胞活化的信号传导中起到调节枢纽的作用;在神经递质的释放、突触可塑性方面亦有重要的调节作用.新近的研究表明,CaN在心肌肥厚的发生发展中起到中心作用.对CaN的分子结构、酶学特性、组织分布、信号传导及生物学功能方面的研究进展进行了介绍. 相似文献
78.
细胞内信号分子传导的研究进展 总被引:7,自引:0,他引:7
近年来有关细胞内信号传导的研究,着重体现在Ca2+信号传导途径及相应的蛋白质分子如蛋白激酶C(PKC)、钙调素(CaM)、钙调素激酶Ⅱ(CaMKⅡ),同时也对Ras途径中出现的Vav、Rap、Crk、C3G等蛋白质分子以及cAMP和NF-κB途径作了有益的补充与修改.细胞外信号分子通过以上4种途径及其相互通讯(cross-talk),激活了某些蛋白激酶,调控了基因转录及其他相关功能,其中磷酸化对蛋白激酶及转录因子活性的调节起到了非常重要的作用. 相似文献
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