排序方式: 共有1条查询结果,搜索用时 0 毫秒
1
1.
Le Cong Huan Duong Tien Anh Bui Xuan Truong Phan Huy Duc Pham‐The Hai Lai Duc‐Anh Le‐Thi‐Thu Huong Eun Jae Park Hye Jin Lee Jong Soon Kang Phuong‐Thao Tran Dinh Thi Thanh Hai Dao Thi Kim Oanh Sang‐Bae Han Nguyen‐Hai Nam 《化学与生物多样性》2020,17(3)
In our search for new small molecules activating procaspase‐3, we have designed and synthesized a series of new acetohydrazides incorporating both 2‐oxoindoline and 4‐oxoquinazoline scaffolds. Biological evaluation showed that a number of these acetohydrazides were comparably or even more cytotoxic against three human cancer cell lines (SW620, colon cancer; PC‐3, prostate cancer; NCI?H23, lung cancer) in comparison to PAC‐1, a first procaspase‐3 activating compound, which was used as a positive control. One of those new compounds, 2‐(6‐chloro‐4‐oxoquinazolin‐3(4H)‐yl)‐N′‐[(3Z)‐5‐methyl‐2‐oxo‐1,2‐dihydro‐3H‐indol‐3‐ylidene]acetohydrazide activated the caspase‐3 activity in U937 human lymphoma cells by 5‐fold higher than the untreated control. Three of the new compounds significantly induced necrosis and apoptosis in U937 cells. 相似文献
1