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Magali Lucia Jean-Marc Andre Patrice Gonzalez Magalie Baudrimont Karine Gontier Regine Maury-Brachet Stephane Davail 《Biometals》2009,22(5):843-853
The impact on palmiped Cairina moschata of two levels of dietary cadmium (Cd) contamination (C1: 1 mg kg−1 and C10: 10 mg kg−1) was investigated on liver gene expression by real-time PCR. Genes involved in mitochondrial metabolism, in antioxidant defences,
detoxification and in DNA damage repair were studied. Metallothionein (MT) protein levels and Cd bioaccumulation were also
investigated in liver, kidneys and muscle. Male ducks were subjected to three periods of exposure: 10, 20 and 40 days. Cd
was mainly bioaccumulated in kidneys first and in liver. The concentrations in liver and kidneys appeared to reach a stable
level at 20 days of contamination even if the concentrations in muscle still increased. Cd triggered the enhancement of mitochondrial
metabolism, the establishment of antioxidant defences (superoxide dismutase Mn and Cu/Zn; catalase) and of DNA repair from
20 days of contamination. Discrepancies were observed in liver between MT protein levels and MT gene up-regulation. MT gene
expression appeared to be a late hour biomarker. 相似文献
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