Mechanism of CFTR correction by type I folding correctors

1. Download : Download high-res image (139KB)
2. Download : Download full-size image

     

Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests

1. Download : Download high-res image (239KB)
2. Download : Download full-size image

     

The facets of olfactory learning

Volatile chemicals in the environment provide ethologically important information to many animals. However, how animals learn to use this information is only beginning to be understood. This review highlights recent experimental advances elucidating olfactory learning in rodents, ranging from adaptations to the environment to task-dependent refinement and multisensory associations. The broad range of phenomena, mechanisms, and brain areas involved demonstrate the complex and multifaceted nature of olfactory learning.     

Enhancing native chemical ligation for challenging chemical protein syntheses

Native chemical ligation has enabled the chemical synthesis of proteins for a wide variety of applications (e.g., mirror-image proteins). However, inefficiencies of this chemoselective ligation in the context of large or otherwise challenging protein targets can limit the practical scope of chemical protein synthesis. In this review, we focus on recent developments aimed at enhancing and expanding native chemical ligation for challenging protein syntheses. Chemical auxiliaries, use of selenium chemistry, and templating all enable ligations at otherwise suboptimal junctions. The continuing development of these tools is making the chemical synthesis of large proteins increasingly accessible.     

KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies

1. Download : Download high-res image (150KB)
2. Download : Download full-size image

     

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

1. Download : Download high-res image (180KB)
2. Download : Download full-size image

     

ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance

1. Download : Download high-res image (163KB)
2. Download : Download full-size image

     

Development,validation and reliability of the Chrononutrition Profile - Questionnaire

ABSTRACT

Chrononutrition, or the circadian timing of food intake, has garnered attention as a topic of study due to its associations with health (e.g. weight gain); however, a valid and reliable assessment of chrononutrition in daily life has not yet been developed. This paper details the development and initial reliability and validity testing of the Chrononutrition Profile – Questionnaire (CP-Q). The CP-Q assesses six components of chrononutrition that are likely to influence health (breakfast skipping, largest meal, evening eating, evening latency, night eating, and eating window). This questionnaire is designed to assess general chrononutrition behaviors and preferred timing of food intake. The CP-Q can be used as a sole evaluation of chrononutrition, and can also be utilized in conjunction with existing dietary measures to provide a comprehensive assessment of one’s eating behaviors. This measure offers health-care professionals, researchers, and stakeholders a cost-effective and comprehensive method of evaluating chrononutrition and identifying targets for health improvement.     

Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED

1. Download : Download high-res image (192KB)
2. Download : Download full-size image