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81.
Andre M Siqueira Janieldo A Cavalcante Shelia Vítor-Silva Roberto C Reyes-Lecca Aline C Alencar Wuelton M Monteiro Márcia AA Alexandre Mour?o Maria Paula G Caterina Guinovart Quique Bassat Maria das Gra?as C Alecrim Marcus VG Lacerda 《Memórias do Instituto Oswaldo Cruz》2014,109(5):569-576
Anaemia is amongst the major complications of malaria, a major public health problem
in the Amazon Region in Latin America. We examined the haemoglobin (Hb)
concentrations of malaria-infected patients and compared it to that of
malaria-negative febrile patients and afebrile controls. The haematological
parameters of febrile patients who had a thick-blood-smear performed at an infectious
diseases reference centre of the Brazilian Amazon between December 2009-January 2012
were retrieved together with clinical data. An afebrile community control group was
composed from a survey performed in a malaria-endemic area. Hb concentrations and
anaemia prevalence were analysed according to clinical-epidemiological status and
demographic characteristics. In total, 7,831 observations were included. Patients
with Plasmodium falciparum infection had lower mean Hb
concentrations (10.5 g/dL) followed by P. vivax-infected individuals
(12.4 g/dL), community controls (12.8 g/dL) and malaria-negative febrile patients
(13.1 g/dL) (p < 0.001). Age, gender and clinical-epidemiological status were
strong independent predictors for both outcomes. Amongst malaria-infected
individuals, women in the reproductive age had considerably lower Hb concentrations.
In this moderate transmission intensity setting, both vivax and falciparum malaria
are associated with reduced Hb concentrations and risk of anaemia throughout a wide
age range. 相似文献
82.
83.
Albert Eduardo Silva Martins Norma Lucena-Silva Renan Gomes Garcia Stefan Welkovic Aureliana Barboza Maria Luiza Bezerra Menezes Magda Maruza Terezinha Tenório Ricardo AA Ximenes 《Memórias do Instituto Oswaldo Cruz》2014,109(6):738-747
Human immunodeficiency virus (HIV)-positive patients have a greater prevalence of
coinfection with human papillomavirus (HPV) is of high oncogenic risk. Indeed, the
presence of the virus favours intraepithelial squamous cell lesion progression and
may induce cancer. The aim of this study was to evaluate the prevalence of HPV
infection, distribution of HPV types and risk factors among HIV-positive patients.
Cervical samples from 450 HIV-positive patients were analysed with regard to oncotic
cytology, colposcopy and HPV presence and type by means of polymerase chain reaction
and sequencing. The results were analysed by comparing demographic data and data
relating to HPV and HIV infection. The prevalence of HPV was 47.5%. Among the
HPV-positive samples, 59% included viral types of high oncogenic risk. Multivariate
analysis showed an association between HPV infection and the presence of cytological
alterations (p = 0.003), age greater than or equal to 35 years (p = 0.002), number of
partners greater than three (p = 0.002), CD4+ lymphocyte count <
200/mm3 (p = 0.041) and alcohol abuse (p = 0.004). Although high-risk
HPV was present in the majority of the lesions studied, the low frequency of HPV 16
(3.3%), low occurrence of cervical lesions and preserved immunological state in most
of the HIV-positive patients were factors that may explain the low occurrence of
precancerous cervical lesions in this population. 相似文献
84.
Archives of Microbiology - 相似文献
85.
86.