Analgesic and hypnosis potentiation effect of some 1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-aryl guanidines.

1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-arylguanidines (I-X) were prepared by oxidation of 1,3-diarylthioureas. The compounds were screened for their analgesic and hypnotic activities in rats. Of these, p-methyl group substituted compound of the series was the most potent analgesic as compared to other compounds of the series. In hypnotic test all the compounds potentiated pentobarbitone-induced hypnosis.     

Taxonomic Significance of Sclerenchyma Distribution in the Secondary Phloem of Some Indian Tropical Trees

Analysis of the relative amount and distribution pattern of phloem sclerenchyma in some 29 tropical trees of India was carried out with systematic considerations. Both the features exhibited considerable diversity among the species analyzed. The extent of area occupied by sclerenchyma in transections of the bark of these species varied from zero to 35% and 3 to 49% in the conducting and non-conducting phloem zones respectively, the overall amount constituting about 3 to 45% of the secondary phloem as a whole. The sclerenchyma cells differentiated either as isolated elements or in the form of bands or fascicles of diverse shape and size showing various distribution patterns.     

Neisseria meningitidis: heterogenicity in the outer membrane proteins released into the growth medium

Eight strains of Neisseria meningitidis belonging to different serogroups were analysed for their virulence in mice and their release of outer membrane proteins into the medium during growth. All strains released proteins. No detectable lipopolysaccharide was observed. However, SDS-PAGE showed a heterogenicity in the protein number and profile among the different strains of N. meningitidis tested.     

Chromosomal mapping and nucleotide sequence of a human DNA autonomously replicating sequence

A 1.1-kb human DNA fragment (ARSH1) capable of functioning as a putative origin of replication in yeast cells has been characterized both by in situ hybridization to human metaphase chromosomes and by DNA sequencing. Our hybridization studies show a preferential localization of ARSH1 in chromosome regions 1p34-36 and 2q34-37. DNA sequence analysis indicates that in addition to the consensus sequence required for ARS function in yeast cells, nuclear matrix-associated DNA motifs are also present in the 1.1-kb fragment. These results suggest that ARSH1 sequences may serve as points of anchorage to the nuclear matrix for chromosomes 1 and 2.