Outcome of Tuberculosis Treatment in Patients with Diabetes Mellitus Treated in the Revised National Tuberculosis Control Programme in Malappuram District,Kerala, India

Settings

Kerala State, India has reported the greatest dual burden of Tuberculosis (TB) and Diabetes Mellitus (DM). Malappuram district in Kerala has monitored and recorded DM status and its control from 2010 under Revised National Tuberculosis Control Program (RNTCP).

Objectives

To assess, under programme conditions, comprehensiveness of recording DM status among TB cases and the TB treatment outcomes among DM patients (disaggregated by glycemic control) and compare with-non DM patients.

Design

This retrospective record review included 3,116TB patients from April 2010 to September 2011.DM was defined as per international guidelines and TB treatment outcomes were categorized as favourable(cured and treatment completed) and unfavourable(death, default, failure and transfer out). Relative Risk (RR) and 95% confidence intervals(CI) were calculated to assess the risk of unfavourable outcomes.

Results

DM status was recorded in 90% of TB cases and 667 (24%) had DM. 17% of DM patients and 23% of patients with unknown DM status had unfavourable outcomes but this difference was not statistically significant. Unadjusted RR for poor glycemic control or unknown control status for unfavourable outcome were (2.00; 95% CI 0.97–4.13) and (2.14; 95% CI 1.11–4.13).

Conclusion

This study could not confirm an adverse association between DM or its control during treatment and the course of response to TB treatment.DM screening in TB cases and recording of DM care needs to be improved to enable more conclusive evidence.     

Quantum dot-containing polymer particles with thermosensitive fluorescence

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A Composite Polyaniline-Containing Silica Sorbent for DNA Isolation

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Isolation and identification of the infective agent of severe acute respiratory syndrome (SARS) from a patient with atypical pneumonia

The virological, morphological, molecular biological and immunochemical study of the infective agent isolated from the patient with the symptoms of atypical pneumonia, hospitalized in the infectious department of the clinical hospital in Blagoveshchensk, was carried out. Thus the fact of the appearance of SARS virus on the territory of Russia was proved. The isolated infective agent, identified as coronavirus strain CoD, was partly characterized and deposited to the virus collection of the Center of Special Laboratory Diagnostics and Treatment of Quarantine and Exotic Infectious Diseases.     

A composite polyaniline-containing silica sorbent for DNA isolation

A composite sorbent based on porous glass beads modified with thin polyaniline coating was prepared by precipitating aniline polymerization in the presence of carrier particles. It was shown that the modification ensures the uniform coating of the inner surface of the carrier pores with the polymer layer approximately 70 A thick. It was shown that the resulting material retains the initial porosity of the carrier and is selective in the separation of nucleic acids and proteins. The polyaniline-coated sorbents were shown to be efficient for both the preparative DNA isolation from bacterial lysates and for analytical purposes, in particular, for studying DNA fragmentation during apoptosis proceeding under UV irradiation of cell lysates of colon carcinoma. The morphological and chromatographic characteristics of the new sorbent were demonstrated to be similar to those of the polyfluorobutadiene sorbent.     

Features of the behaviour of double-chained cationic surfactant monomer in a monolayer at the water-gas interface

We studied the formation of a double-chained cationic monomer, N,N-diallyl-N-cetyl-N-dodecyloxycarbonyl methylammonium bromide, in a monolayer at the water-gas interface. An increase in surface pressure induced the transition from the liquid-expanded to liquid-condensed state with tail-packing and then head-packing of the monomer, which was accompanied by a decrease in the mobility of monomer molecules. An increase in the ionic strength of the subphase led to the compression of the layer, and addition of ethanol or detergents caused its dilution. Polyethylene glycol and polyacrylic acid induced the formation of a complex between the monomer and polymer.     

Turbidimetric study of latex agglutination in 2,4-dichlorophenoxyacetic acid analysis

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Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration

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Immobilization of glucose oxidase via carbohydrate moiety onto hydrazide derivative of polyacrylate-coated porous glass

Summary The hydrazide derivative of polyacrylate-coated glass was used for the immobilization of glucose oxidase (GO) from Penicillium vitale after periodate oxidation of its carbohydrate moiety. Periodate oxidation of the carbohydrate residues did not influence catalytic activity of the enzyme. Immobilized GO is extremely stable both at 4°C and 25°C for extended period.