排序方式: 共有66条查询结果,搜索用时 0 毫秒
61.
Mehmet Ziya Yilmaz Aygul Guzel Aysun Caglar Torun Ali Okuyucu Osman Salis Rifat Karli Ayhan Gacar Tolga Guvenc Sule Paksu Volkan Urey Naci Murat Hasan Alacam 《Journal of molecular histology》2014,45(2):195-203
Aspiration pneumonitis refers to acute chemical lung injury caused by aspiration of sterile gastric contents. The aim of this study was to evaluate the role of quercetin (QC) in acid aspiration-induced lung injury in rats. Twenty-eight female Sprague–Dawley rats were used and divided into the following groups (n = 7): sham (aspirated normal saline, S), hydrochloric acid (aspirated HCl), S plus treatment with QC (S + QC), and HCl plus treatment with QC (HCl + QC). After aspiration, the treatment groups received QC 60 mg/kg/day intraperitoneally once a day for 7 days. As a result of acid aspiration, an increase was observed in the levels of serum clara cell protein-16 (CC-16) and advanced oxidation protein products, whereas there was a decrease in serum thiobarbituric acid-reactive substances, superoxide dismutase (SOD), and catalase levels. There was a significant decrease in peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, and alveolar exudate scores, except in the alveolar histiocytes in the HCl + QC group. The expression of nitric oxide synthase, which increased after aspiration in the HCl group, showed a statistically significant decrease after the QC treatment. After the treatment with QC, an increase in the serum SOD level was observed, whereas a significant decrease was determined in the serum CC-16 level relative to that of the aspiration group (HCl). The antioxidant QC is effective in the treatment of lung injury following acid aspiration and can be used as a serum CC-16 biomarker in predicting the severity of oxidative lung injury. 相似文献
62.
Sakru N Ozensoy Toz S Korkmaz M Kavakli T Alkan MZ Ozbel Y 《Parasitology international》2006,55(2):131-133
Human visceral leishmaniasis (HVL), caused by Leishmania infantum is mainly observed as sporadic cases in Turkey and dogs are considered as the main reservoir of the disease. The incidence of visceral leishmaniasis among members of households where a HVL infection has already been diagnosed was studied in clusters around the diagnosed cases in different regions in Turkey. A total of 47 serum samples collected from the households of 11 proven visceral leishmaniasis patients were screened for anti-Leishmania antibodies by indirect immunofluorescent antibody test (IFAT). Three and one such household members belonging to the different families were found to be seropositive and borderline, respectively. Diagnosis was confirmed with the presence of amastigotes in bone marrow aspiration samples in all seropositives while the borderline case with slight and indefinitive symptoms of VL was followed only serologically at 3-month intervals and improved spontaneously in 1 year. Household members of individuals with previously confirmed visceral leishmaniasis were found to have higher frequency of the disease suggesting the household members should be included in the risk group for visceral leishmaniasis and serological screening should be performed for the detection of possible infection. 相似文献
63.
64.
65.
Sandrine Mathieu Jérémie Wirth François-Xavier Sauvage Jean-Paul Lepoutre Raymond Baumes Ziya Gunata 《Plant Cell, Tissue and Organ Culture》2009,97(2):203-213
A cell suspension culture of cv. Gamay was studied for its ability to metabolize two different C13-norisoprenoidic volatiles, β-ionone and dehydrovomifoliol, together with monoterpenes, geraniol and linalool, biogenetically
common pathways sharing compounds. β-Ionone was totally metabolized leading to fourteen norisoprenoidic volatiles oxygenated
mainly at carbons 3 or 4 of the cyclohexane ring or reduced at side chain. The biotransformation of dehydrovomifoliol was
at a lesser extent, giving rise to oxygenated and reduced derivatives. The norisoprenoidic metabolites were present both under
free and glycosylated forms. Geraniol and linalool were also metabolized, leading to several free and glycosylated compounds.
S. Mathieu, J. Wirth contributed equally to the work and should be considered joint first authors.
A short part of this paper was published at the proceedings of the 10th Weurman Flavour Research Symposium, Flavour Research
at the Dawn of the Twenty-first Century, J.-L.Le Quere, P.-X.Etievant, Editors; Lavoisier,2003/Intercept Ltd, 2003. 相似文献
66.