中国木雅人、尔苏人、八甲人与空格人6项不对称行为的特征

对四川、云南尔苏人、木雅人、空格人、八甲人4个族群进行了6项不对称行为特征(扣手、利手、叠臂、利足、叠腿、起步)的调查,结果显示:1)4个族群中,仅尔苏人、木雅人、八甲人叠臂以L型出现率偏高以外,其余不对称行为特征均为R型出现率较高;2)4个族群6项不对称行为特征均不存在性别间差异,但木雅人、尔苏人与八甲人在扣手这一不对称行为特征上存在族群间差异,木雅人与空格人在叠臂这一不对称行为特征上存在族群间差异;3)统计分析了6项不对称行为特征之间的相关性,仅八甲人多数不对称行为特征之间存在相关性。     

Synthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma

Based on the two antigenic peptides, 26-43 (P26) and 116-131 (P116), derived from 28 kDa glutathione S-transferase of Schistosoma mansoni (Sm28GST), two multiple antigenic peptides (MAPs), (P26)4-MAP and (P116)4-MAP with the same oligomeric lysine core, were synthesized by stepwise solid-phase peptide synthesis method. The antigenicities and protective effects of these two MAPs were examined on experimental animals. As shown in the dot-ELISA result, the synthetic MAPs could be recognized and bound by immunoglobins in both patient's and infected-rabbit's sera. After Kunming mice were immunized with (P26)4-MAP, the worm burden reduction rate and the liver egg reduction rate were 59.9% and 61.1%. In (P26)4-MAP or (P116)4-MAP immunized BALB/c mice, the worm burden reduction rates were 37.5% and 62.5%, respectively, and the liver egg reduction rates were 35.1% and 54.0%, respectively.     

Maximum likelihood estimation of two-level latent variable models with mixed continuous and polytomous data

Two-level data with hierarchical structure and mixed continuous and polytomous data are very common in biomedical research. In this article, we propose a maximum likelihood approach for analyzing a latent variable model with these data. The maximum likelihood estimates are obtained by a Monte Carlo EM algorithm that involves the Gibbs sampler for approximating the E-step and the M-step and the bridge sampling for monitoring the convergence. The approach is illustrated by a two-level data set concerning the development and preliminary findings from an AIDS preventative intervention for Filipina commercial sex workers where the relationship between some latent quantities is investigated.