全文获取类型
收费全文 | 335篇 |
免费 | 23篇 |
专业分类
358篇 |
出版年
2024年 | 3篇 |
2023年 | 10篇 |
2022年 | 13篇 |
2021年 | 25篇 |
2020年 | 19篇 |
2019年 | 48篇 |
2018年 | 28篇 |
2017年 | 14篇 |
2016年 | 13篇 |
2015年 | 10篇 |
2014年 | 14篇 |
2013年 | 29篇 |
2012年 | 23篇 |
2011年 | 16篇 |
2010年 | 13篇 |
2009年 | 10篇 |
2008年 | 12篇 |
2007年 | 9篇 |
2006年 | 9篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 6篇 |
2002年 | 3篇 |
2001年 | 1篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1984年 | 1篇 |
1980年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1934年 | 1篇 |
排序方式: 共有358条查询结果,搜索用时 15 毫秒
101.
Mohammadghasemi Vida Siavash Moghaddam Sina Rahimi Amir Pourakbar Latifeh Popović-Djordjević Jelena 《Journal of Plant Growth Regulation》2021,40(4):1714-1727
Journal of Plant Growth Regulation - Dragon’s head is a multifunctional plant with diverse applications so that all its parts, including its leaves and seeds, have nutritional value. For the... 相似文献
102.
Plasmonics - Bethe’s theory treats a subwavelength aperture in a metal film as the combination of a parallel magnetic dipole and transverse electric dipole. For linear optics, this gives the... 相似文献
103.
104.
Ziba Sorinezami Mohammad Aminzadeh Arezou Ghahghaei Nasimeh Jamgohari Mostafa Heidari Majd 《Journal of biomolecular structure & dynamics》2013,31(16):4238-4250
AbstractBetter solubility and improved toxicity of palladium complexes compared with cisplatin were major reasons for synthesis of novel Pd(II) complex, [Pd(8Q)(bpy)]NO3 (8Q=8-hydroxyquinolinate, bpy=2,2′-bipyridine). Interaction between the [Pd(8Q)(bpy)]NO3 complex and calf thymus DNA in aqueous solution has been investigated by circular dichroism (CD), UV-Visible absorption and fluorescence spectroscopic techniques. These experiments showed that prepared Pd(II) complex can effectively intercalate into CT-DNA and weakly bind to BSA in which the bovine serum albumin molecule was unfolded slightly. The cytotoxicity of the prepared complex has been evaluated on the MCF-7 and DU145 cell lines by MTT and TUNEL assay. The MTT results were showed that in DU145, the CC50 values of [Pd(8Q)(bpy)]NO3 and cisplatin are very close together (10.4 and 8.3?μM, respectively), unlike MCF-7. Accordingly, TUNEL assay was performed on DU145 and apoptosis was clearly obvious by 43% DNA fragmentation in the treated cell lines. So, we can suggest the [Pd(8Q)(bpy)]NO3 as alternative drug for cisplatin in the future which has great potential in DNA denaturation and apoptosis specially on prostate cancer. PdO nanoparticles were successfully prepared without supported any surfactants via sonochemical approach. The synthesized PdONPs were characterized using UV-Vis and FTIR spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM) and transmission electron microscopy (TEM).Communicated by Ramaswamy H. Sarma 相似文献
105.
Roghayeh Sheervalilou Milad Shirvaliloo Nahid Dadashzadeh Sakine Shirvalilou Omolbanin Shahraki Younes Pilehvar-Soltanahmadi Habib Ghaznavi Samideh Khoei Ziba Nazarlou 《Journal of cellular physiology》2020,235(12):8873-8924
Months after the outbreak of a new flu-like disease in China, the entire world is now in a state of caution. The subsequent less-anticipated propagation of the novel coronavirus disease, formally known as COVID-19, not only made it to headlines by an overwhelmingly high transmission rate and fatality reports, but also raised an alarm for the medical community all around the globe. Since the causative agent, SARS-CoV-2, is a recently discovered species, there is no specific medicine for downright treatment of the infection. This has led to an unprecedented societal fear of the newly born disease, adding a psychological aspect to the physical manifestation of the virus. Herein, the COVID-19 structure, epidemiology, pathogenesis, etiology, diagnosis, and therapy have been reviewed. 相似文献
106.
Keiyo Takubo Go Nagamatsu Chiharu I. Kobayashi Ayako Nakamura-Ishizu Hiroshi Kobayashi Eiji Ikeda Nobuhito Goda Yasmeen Rahimi Randall S. Johnson Tomoyoshi Soga Atsushi Hirao Makoto Suematsu Toshio Suda 《Cell Stem Cell》2013,12(1):49-61
Highlights? LT-HSCs activate glycolysis and generate ATP in a HIF-1α-dependent manner ? Pdk overexpression in HIF-1αΔ/Δ HSCs restored glycolysis and stem cell capacity ? Pdk2?/?: Pdk4?/? LT-HSCs show defective glycolysis and cell cycle quiescence ? Pdk mimetic promotes the survival and transplantation capacity of LT-HSCs 相似文献
107.
Elnaz Salahi Zivar Salehi Ziba Zahiri Saeedeh Sadri Niloofar Khoshdel Rad 《Genes & genomics.》2013,35(5):563-567
Endometriosis is a multifactorial gynecological condition characterized by the presence of ectopic endometrial and stromal tissue outside the uterus. Free radicals and Oxidative stress have been proposed to be involved in the pathogenesis of the endometriosis. It has been shown that mitochondrial DNA (mtDNA) is particularly susceptible to oxidative damage and mutations due to the high rate of reactive oxygen species production and limited DNA repair capacity in mitochondria. While a number of deletions can occur, the most commonly studied in human is a 4977-bp deletion that removes all or parts of the genes for NADH dehydrogenase subunits 3, 4, 4L and 5, cytochrome C oxidase subunit III and ATP synthase subunits 6 and 8.” We evaluated whether mtDNA common deletion is related with the susceptibility to endometriosis in northern Iran. In this study 80 endometriosis cases and 100 controls were enrolled. Total DNA was extracted from endometrial tissue samples. The mitochondrial common deletion was determined by Gap- polymerase chain reaction (Gap-PCR). It was found that the mitochondrial common deletion was more likely to be present in patients with endometriosis. Assessing indicate that 60 % of patients and 8 % of controls show mtDNA 4977-bp deletion (Odds Ratio [OR] = 17.25, P < 0.0001, confidence interval [CI] = 5.18–57.36). The mtDNA 4977 deletion may play a role in endometriosis. Further studies with larger numbers of patients are required for further evaluation and confirmation of our finding. 相似文献
108.
Gharbavi Mahmoud Johari Behrooz Mousazadeh Navid Rahimi Bahareh Leilan Milad Parvinzad Eslami Seyed Sadegh Sharafi Ali 《Molecular biology reports》2020,47(9):6517-6529
Molecular Biology Reports - The current study intends to investigate a novel drug delivery system (DDS) based on niosomes structure (NISM) and bovine serum albumin (BSA) which was... 相似文献
109.
Vaisi-Raygani A Ghaneialvar H Rahimi Z Tavilani H Pourmotabbed T Shakiba E Vaisi-Raygani A Kiani A Aminian M Alibakhshi R Bartels C 《Molecular biology reports》2011,38(8):5421-5428
The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial. The aim of the present study was to evaluate whether the PON1 gene polymorphism is an independent risk factor for severity of coronary artery disease in patients from west of Iran. The PON1-Arg-192 genotypes were detected by PCR-RFLP in 414 individuals undergoing their first coronary angiography. Patients were placed into one of two groups: CAD and control without CAD or diabetes. The frequency of PON1-Arg-192 allele was significantly higher in the CAD (23.4 vs. 16%, P = 0.032) than in the control group and there was a higher risk of developing CAD (OR = 1.6, P = 0.02). In addition, this difference remained significant after adjustment for without history of diabetes (OR = 1.47, P = 0.048), presence of normolipidemia and absence of history of blood pressure (OR = 1.4, P = 0.05). This result indicated PON1-Arg-192 allele is a risk factor of CAD also when correcting for conventional risk factors. We found a significant association between the PON1-Arg-192 genotype (QR + RR) and the extent of CAD in CAD patients and CAD subjects without diabetes, represented by the increased frequency of three-vessel disease with OR = 1.49, P = 0.046; χ2 = 3.82, P = 0.048 and OR = 1.46, P = 0.05; χ2 = 3.48, P = 0.051, respectively. The CAD patients carrying PON1-Arg-192 genotype (QR + RR) had lower plasma HDL-C level (P = 0.019) and higher plasma LDL-C(P = 0.01) and TG(P = 0.05). Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of three-vessel disease and also having a distinct plasma lipids profile. Larger collaborative studies are needed to confirm these results. 相似文献
110.