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141.
Cong Wang Liping Jiang Saiqi Wang Hongge Shi Junwei Wang Ran Wang Yongmei Li Yinhui Dou Ying Liu Guiqin Hou Yu Ke Hongmin Liu 《PloS one》2015,10(6)
Jesridonin, a small molecule obtained through the structural modification of Oridonin, has extensive antitumor activity. In this study, we evaluated both its in vitro activity in the cancer cell line EC109 and its in vivo effect on tumor xenografts in nude mice. Apoptosis induced by Jesridonin was determined using an MTT assay, Annexin-V FITC assay and Hoechest 33258 staining. Apoptosis via mitochondrial and death receptor pathways were confirmed by detecting the regulation of MDM2, p53, and Bcl-2 family members and by activation of caspase-3/-8/-9. In addition, vena caudalis injection of Jesridonin showed significant inhibition of tumor growth in the xenograft model, and Jesridonin-induced cell apoptosis in tumor tissues was determined using TUNEL. Biochemical serum analysis of alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT), total protein (TP) and albumin (ALB) indicated no obvious effects on liver function. Histopathological examination of the liver, kidney, lung, heart and spleen revealed no signs of JD-induced toxicity. Taken together, these results demonstrated that Jesridonin exhibits antitumor activity in human esophageal carcinomas EC109 cells both in vitro and in vivo and demonstrated no adverse effects on major organs in nude mice. These studies provide support for new drug development. 相似文献
142.
Di Kang Dou Wang Jianbing Xu Chao Quan Xuan Guo Heng Wang Jun Luo Zhongzhou Yang Shuai Chen Jiong Chen 《Developmental cell》2018,44(4):524-531.e5
143.
Levamisole suppresses adipogenesis of aplastic anaemia‐derived bone marrow mesenchymal stem cells through ZFP36L1‐PPARGC1B axis
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144.
Tengfei Dou Zhengtian Li Kun Wang Lixian Liu Hua Rong Zhiqiang Xu Ying Huang Dahai Gu Xiaobo Chen Wenyuan Hu Jiarong Zhang Sumei Zhao Markandeya Jois Qihua Li Changrong Ge Marinus F. W. te Pas Junjing Jia 《Molecular biology reports》2018,45(4):511-522
Myostatin is a negative regulator of skeletal muscle growth. Muscle tissue is the largest tissue in the body and influences body growth. Commercial Avian broiler chickens are selected for high growth rate and muscularity. Daweishan mini chickens are a slow growing small-sized chicken breed. We investigated the relations between muscle (breast and leg) myostatin mRNA expression and body and muscle growth. Twenty chickens per breed were slaughtered at 0, 30, 60, 90, 120, and 150 days of age. Body and muscle weights were higher at all times in Avian chickens. Breast muscle myostatin expression was higher in Avian chickens than in Daweishan mini chickens at day 30. Myostatin expression peaked at day 60 in Daweishan mini chickens and expression remained higher in breast muscle. Daweishan mini chickens myostatin expression correlated positively with carcass weight, breast and leg muscle weight from day 0 to 60, and correlated negatively with body weight from day 90 to 150, while myostatin expression in Avian chickens was negatively correlated with carcass and muscle weight from day 90 to 150. The results suggest that myostatin expression is related to regulation of body growth and muscle development, with two different regulatory mechanisms that switch between days 30 and 60. 相似文献
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147.
A Novel Graphene Oxide Wrapped Na2Fe2(SO4)3/C Cathode Composite for Long Life and High Energy Density Sodium‐Ion Batteries
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Mingzhe Chen David Cortie Zhe Hu Huile Jin Shun Wang Qinfen Gu Weibo Hua Enhui Wang Weihong Lai Lingna Chen Shu‐Lei Chou Xiao‐Lin Wang Shi‐Xue Dou 《Liver Transplantation》2018,8(27)
The cathode materials in the Na‐ion battery system are always the key issue obstructing wider application because of their relatively low specific capacity and low energy density. A graphene oxide (GO) wrapped composite, Na2Fe2(SO4)3@C@GO, is fabricated via a simple freeze‐drying method. The as‐prepared material can deliver a 3.8 V platform with discharge capacity of 107.9 mAh g?1 at 0.1 C (1 C = 120 mA g?1) as well as offering capacity retention above 90% at a discharge rate of 0.2 C after 300 cycles. The well‐constructed carbon network provides fast electron transfer rates, and thus, higher power density also can be achieved (75.1 mAh g?1 at 10 C). The interface contribution of GO and Na2Fe2(SO4)3 is recognized and studied via density function theory calculation. The Na storage mechanism is also investigated through in situ synchrotron X‐ray diffraction, and pseudocapacitance contributions are also demonstrated. The diffusion coefficient of Na+ ions is around 10?12–10?10.8 cm2 s?1 during cycling. The higher working voltage of this composite is mainly ascribed to the larger electronegativity of the element S. The research indicates that this well‐constructed composite would be a competitive candidate as a cathode material for Na‐ion batteries. 相似文献
148.
Peste des petits ruminants (PPR) is a highly contagious transboundary animal disease with a severe socio-economic impact on the livestock industry, particularly in poor countries where it is endemic. Full understanding of PPR virus (PPRV) pathobiology and molecular biology is critical for effective control and eradication of the disease. To achieve these goals, establishment of stable reverse genetics systems for PPRV would play a key role. Unfortunately, this powerful technology remains less accessible and poorly documented for PPRV. In this review, we discussed the current status of PPRV reverse genetics as well as the recent innovations and advances in the reverse genetics of other non-segmented negative-sense RNA viruses that could be applicable to PPRV. These strategies may contribute to the improvement of existing techniques and/or the development of new reverse genetics systems for PPRV. 相似文献
149.
Persistence and Periodic Solutions of a System of Two Competing Species with Functional Response 总被引:3,自引:0,他引:3
Dou Jiawei 《生物数学学报》1997,(1)
1IntroductionOneofthemOStnit~tingquestionsinrnathernaticalbiologyconcernsthesurvivalofspeCiesinecologiCalmodels.Perslstenceisanimportantconceptindabingwiththeseproblems.Therearemanyliteraturesaboutthedy'ndricsofdiffuSivecompetingspeCies,butthefunctionalresPOnseofthisfOITnhasnotbeenst'Udiedtoomuchyet.Inthispaper,weconsiderthepersistenceproblemforanonautonomoussystemoftwOcompetingspecieswithfunctionalreSPOnse,themodelweconsiderinthispaperishereallri(t),ail(t),D,(t)anda(t)areassumedtobecon… 相似文献
150.
Alendronate induces osteoclast precursor apoptosis via peroxisomal dysfunction mediated ER stress
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