Promotive effect of chrysanthemic acids on adventitious root formation in some plants

Adventitious root formation in excised cucumber (Cucumis sativus L.) cotyledons was significantly promoted by (±)-cis-chrysanthemic acid at 0.006–1.8 mM. The effect of (±)-cis-chrysanthemic acid on indole-3-acetic acid (IAA)-induced rooting was additive. Rooting in excised cucumber cotyledons was significantly promoted by several isomers of chrysanthemic acid and sodium (±)-cis-chrysanthemate at 0.18 mM. Rooting in mung bean (Phaseolus radiatus L.) hypocotyls was also stimulated by the sodium salt at 0.06–0.6 mM. Rooting of kidney bean (Phaseolus vulgaris L.) hypocotyls was also clearly enhanced by sodium (±)-cis-chrysanthemate at 0.18–6 mM.     

中国野生牡丹研究（一）芍药属牡丹组新分类群

牡丹为我国特产珍贵花树和药用树种,已有1500余年栽培历史,建国以来,各地栽培品种已达500余个。 有关牡丹分类的主要研究成果多为西方科学家根据18—19世纪从我国引种到英、美、法等国的栽培牡丹和腊叶标本加以描述和定名。 作者近几年来在安徽、河南、湖南、山西、陕西、甘肃、四川、云南等地对我国野生牡丹进行了较广泛的调查和研究。 本文发表3个新种和1个新等级,这对研究我国栽培牡丹的起源和栽培品种的自然分类,发掘、保护、利用我国珍稀野生牡丹基因资源,培育新品种,扩大牡丹栽培地区等方面提供了科学理论依据。     

Economic burden of dengue fever in China: A retrospective research study

BackgroundDengue fever has been a significant public health challenge in China. This will be particularly important in the context of global warming, frequent international travels, and urbanization with increasing city size and population movement. In order to design relevant prevention and control strategies and allocate health resources reasonably, this study evaluated the economic burden of dengue fever in China in 2019.MethodsThe economic burden of dengue fever patients was calculated from both family and the organisation perspectives. A survey was conducted among 1,027 dengue fever patients in Zhejiang, Chongqing, and Yunnan Provinces. Treatment expenses, lost working days, and insurance reimbursement expenses information were collected to estimate the total economic burden of dengue fever patients in 2019. The expenditures related to dengue fever prevention and control from government, Center for Disease Control and Prevention (CDC), communities and subdistrict offices of 30 counties (or districts) in Zhejiang Province and Chongqing City were also collected.ResultsThe direct, indirect and total economic burden for dengue fever patients in 2019 in the three Provinces were about 36,927,380.00 Chinese Yuan (CNY), 10,579,572.00 CNY and 46,805,064.00 CNY, respectively. The costs for prevention and control of dengue fever for the counties (or districts) without cases, counties (or districts) with imported cases, and counties (or districts) with local cases are 205,800.00 CNY, 731,180.00 CNY and 6,934,378.00 CNY, respectively. The total investment of dengue fever prevention and control in the 30 counties in China in 2019 was approximately 3,166,660,240.00 CNY.ConclusionThe economic burden of dengue fever patients is relatively high, and medical insurance coverage should be increased to lighten patients’ direct medical economic burden. At the same time, the results suggests that China should increase funding for primary health service institutions to prevent dengue fever transmission.     

Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer

A series of 1,2,3-triazole analogues as novel fat mass and obesity-associated protein (FTO) inhibitors were synthesised in this study. Among all 1,2,3-triazoles, compound C6 exhibited the most robust inhibition of FTO with an IC₅₀ value of 780 nM. It displayed the potent antiproliferative activity against KYSE-150, KYSE-270, TE-1, KYSE-510, and EC109 cell lines with IC₅₀ value of 2.17, 1.35, 0.95, 4.15, and 0.83 μM, respectively. In addition, C6 arrested the cell cycle at G2 phase against TE-1 and EC109 cells in a concentration-dependent manner. Analysis of cellular mechanisms demonstrated that C6 concentration-dependently regulated epithelial mesenchymal transition (EMT) pathway and PI3K/AKT pathway against TE-1 and EC109 cells. Molecular docking studies that C6 formed important hydrogen-bond interaction with Lys107, Asn110, Tyr108, and Leu109 of FTO. These findings suggested that C6 as a novel FTO inhibitor and orally antitumor agent deserves further investigation to treat esophageal cancer.     

不同施肥处理对土壤水稳定性团聚体及有机碳分布的影响

以国家褐潮土16 a的长期肥料试验为平台(北京昌平),研究长期不同施肥对耕层土壤水稳定性团聚体及其有机碳的影响。主要研究结果:与耕种农田土壤相比,长期撂荒(CK0)可以提高水稳定性大团聚体的含量及其有机碳含量和储量。而农田耕作后,破坏了水稳性大团聚体,相应地增加水稳性微团聚体的含量。与长期不施肥种植作物(CK)相比,长期施氮磷钾肥(NPK)、氮磷钾配施有机肥(NPKM)和氮磷钾秸秆还田(NPKS)处理对水稳性团聚体数量分布和平均重量直径(MWD)有显著影响,其中对2mm和0.25 2mm水稳性大团聚体的促进作用最明显,说明施肥处理增加的新碳主要向0.25 2mm和2mm团聚体富集。在不同水平水稳性团聚体中,2mm和0.25 2mm两个级别的水稳性大团聚体有机碳的含量显著高于0.0530.25mm和0.053mm水稳性微团聚体。化肥与有机肥配施(NPKM)处理可提高水稳性大团聚体含量,改善土壤团聚体的结构。长期小麦-玉米→小麦-大豆复种轮作并施氮磷钾化肥的处理(NPKF)各级团聚体中有机碳的含量高于长期小麦-玉米轮作并施氮磷钾化肥的处理(NPK)。