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181.
Zhong Yujie Jin Chengni Han Jiahui Zhu Jiachang Liu Qi Sun Dianjun Xia Xiaodong Peng Xiaoli 《Cell biology and toxicology》2021,37(5):795-809
Cell Biology and Toxicology - 3-Chloro-1, 2-propanediol (3-MCPD) is a food-borne toxic substance well-known for more than 40 years that is mainly associated with nephrotoxicity. A better... 相似文献
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Pengcheng Wang John T Burley Yang Liu Jiang Chang De Chen Qi Lu Shou-Hsien Li Xuming Zhou Scott Edwards Zhengwang Zhang 《Molecular biology and evolution》2021,38(1):263
Population genetic theory and empirical evidence indicate that deleterious alleles can be purged in small populations. However, this viewpoint remains controversial. It is unclear whether natural selection is powerful enough to purge deleterious mutations when wild populations continue to decline. Pheasants are terrestrial birds facing a long-term risk of extinction as a result of anthropogenic perturbations and exploitation. Nevertheless, there are scant genomics resources available for conservation management and planning. Here, we analyzed comparative population genomic data for the three extant isolated populations of Brown eared pheasant (Crossoptilon mantchuricum) in China. We showed that C. mantchuricum has low genome-wide diversity and a contracting effective population size because of persistent declines over the past 100,000 years. We compared genome-wide variation in C. mantchuricum with that of its closely related sister species, the Blue eared pheasant (C. auritum) for which the conservation concern is low. There were detrimental genetic consequences across all C. mantchuricum genomes including extended runs of homozygous sequences, slow rates of linkage disequilibrium decay, excessive loss-of-function mutations, and loss of adaptive genetic diversity at the major histocompatibility complex region. To the best of our knowledge, this study is the first to perform a comprehensive conservation genomic analysis on this threatened pheasant species. Moreover, we demonstrated that natural selection may not suffice to purge deleterious mutations in wild populations undergoing long-term decline. The findings of this study could facilitate conservation planning for threatened species and help recover their population size. 相似文献
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Liu Jin Yue Sheng Ze Wen Hu Yu Qi Liu Qi Qiang Sheng Song Xiao Ling Liu Biao 《Transgenic research》2021,30(1):105-119
Transgenic Research - The releasing of transgenic soybeans (Glycine max (L.) Merr.) into farming systems raises concerns that transgenes might escape from the soybeans via pollen into... 相似文献
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