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排序方式: 共有243条查询结果,搜索用时 15 毫秒
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Azarmehr Zahra Ranji Najmeh Khazaei Koohpar Zeinab Habibollahi Hadi 《Molecular biology reports》2021,48(3):2533-2542
Molecular Biology Reports - The aim of this study was to consider the expression of farnesoid X receptor (Fxr), liver X receptor (LXRα) and sirtuin 1 (Sirt1), oxidative stress, inflammation,... 相似文献
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Abedien Zabardasti Ali Kakanejadi Fatemeh Ghenaatian Zeinab Bigleri 《Molecular simulation》2013,39(12):960-968
Ab initio and density functional calculations are used to analyse the interaction between a molecule of the cyanuric acid and one, two and three molecules of water at B3LYP/6-311++ G(d,p) and MP2/6-311++ G(d,p) computational levels. Also, the cooperative effect (CE) in terms of the stabilisation energy of clusters is calculated and discussed. Depending on the geometry of clusters under study, the cooperative, non- or anti-CE was found with an increasing cluster size. Red shifts of N–H and C = O stretching frequencies illustrate a good dependence on the CE. The atoms in molecules theory is used to analyse the CE on topological parameters. 相似文献
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Shams Nemat Shakarami Gandabeh Zeinab Nazifi Narges Forouharmehr Ali Jaydari Amin Rashidian Ehsan 《International journal of peptide research and therapeutics》2020,26(3):1527-1539
International Journal of Peptide Research and Therapeutics - Salmonella is a gram-negative bacterium belonging to the Enterobacteriaceae family. One of the major known serotypes of this bacterium... 相似文献
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Mohamed TM Oceandy D Zi M Prehar S Alatwi N Wang Y Shaheen MA Abou-Leisa R Schelcher C Hegab Z Baudoin F Emerson M Mamas M Di Benedetto G Zaccolo M Lei M Cartwright EJ Neyses L 《The Journal of biological chemistry》2011,286(48):41520-41529
Identification of the signaling pathways that regulate cyclic nucleotide microdomains is essential to our understanding of cardiac physiology and pathophysiology. Although there is growing evidence that the plasma membrane Ca(2+)/calmodulin-dependent ATPase 4 (PMCA4) is a regulator of neuronal nitric-oxide synthase, the physiological consequence of this regulation is unclear. We therefore tested the hypothesis that PMCA4 has a key structural role in tethering neuronal nitric-oxide synthase to a highly compartmentalized domain in the cardiac cell membrane. This structural role has functional consequences on cAMP and cGMP signaling in a PMCA4-governed microdomain, which ultimately regulates cardiac contractility. In vivo contractility and calcium amplitude were increased in PMCA4 knock-out animals (PMCA4(-/-)) with no change in diastolic relaxation or the rate of calcium decay, showing that PMCA4 has a function distinct from beat-to-beat calcium transport. Surprisingly, in PMCA4(-/-), over 36% of membrane-associated neuronal nitric-oxide synthase (nNOS) protein and activity was delocalized to the cytosol with no change in total nNOS protein, resulting in a significant decrease in microdomain cGMP, which in turn led to a significant elevation in local cAMP levels through a decrease in PDE2 activity (measured by FRET-based sensors). This resulted in increased L-type calcium channel activity and ryanodine receptor phosphorylation and hence increased contractility. In the heart, in addition to subsarcolemmal calcium transport, PMCA4 acts as a structural molecule that maintains the spatial and functional integrity of the nNOS signaling complex in a defined microdomain. This has profound consequences for the regulation of local cyclic nucleotide and hence cardiac β-adrenergic signaling. 相似文献
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Silja Lucia Salscheider Sarah Gerlich Alfredo CabreraOrefice Esra Peker Robin Alexander Rothemann Lena Maria Murschall Yannik Finger Karolina Szczepanowska Zeinab Alsadat Ahmadi Sergio GuerreroCastillo Alican Erdogan Mark Becker Muna Ali Markus Habich Carmelina Petrungaro Nele Burdina Guenter Schwarz Merlin Klußmann Ines Neundorf David A Stroud Michael T Ryan Aleksandra Trifunovic Ulrich Brandt Jan Riemer 《The EMBO journal》2022,41(17)
The mitochondrial intermembrane space protein AIFM1 has been reported to mediate the import of MIA40/CHCHD4, which forms the import receptor in the mitochondrial disulfide relay. Here, we demonstrate that AIFM1 and MIA40/CHCHD4 cooperate beyond this MIA40/CHCHD4 import. We show that AIFM1 and MIA40/CHCHD4 form a stable long‐lived complex in vitro, in different cell lines, and in tissues. In HEK293 cells lacking AIFM1, levels of MIA40 are unchanged, but the protein is present in the monomeric form. Monomeric MIA40 neither efficiently interacts with nor mediates the import of specific substrates. The import defect is especially severe for NDUFS5, a subunit of complex I of the respiratory chain. As a consequence, NDUFS5 accumulates in the cytosol and undergoes rapid proteasomal degradation. Lack of mitochondrial NDUFS5 in turn results in stalling of complex I assembly. Collectively, we demonstrate that AIFM1 serves two overlapping functions: importing MIA40/CHCHD4 and constituting an integral part of the disulfide relay that ensures efficient interaction of MIA40/CHCHD4 with specific substrates. 相似文献
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Ali Ranjbaran Zeinab Latifi Hamid Reza Nejabati Sina Abroon Aynaz Mihanfar Aydin Raei Sadigh Amir Fattahi Mohammad Nouri Nathalie Raffel 《Journal of cellular physiology》2019,234(11):19212-19222
Different strategies are applied for cellular cross-talk and organization in multicellular organisms. Exosomes are a homogenous population of biological nanoparticles (30–100 nm), originated from multivesicular bodies. The exosomes (Exos) could regulate and affect both cellular physiology and pathophysiology in various organs, such as the female reproductive tract, by altering gene pathways and/or epigenetic programming. Besides, engineered Exos have the potential to be used as a novel drug and gene delivery tools. Here in this review, we discussed various aspects of exosome-based intercellular communication in female reproductive microenvironments. Furthermore, we addressed the findings and issues related to Exos in reproductive biology to give a better view of the involved molecular mechanisms. Moreover, clinical applications of the Exos and their isolation source/methods have been considered to throw some light on the progression of new biological, diagnostic, and therapeutic approaches in clinical embryology. 相似文献
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