In this paper, we demonstrate a novel salinity sensor based on Tamm-plasmon-polariton (TPP), comprising different shapes of Bragg reflector (ordinary, texturing, and sawtooth) and metallic layer. The finite element method is used to study the considered structure and sensing performance by using the COMSOL multiphysics simulation procedure. Here, we study the effect of surface morphology on the sensitivity; firstly, in the case of one-dimensional photonic crystal-centered defect, it harms the sensitivity; secondly, texturing and sawtooth in the case of Tamm resonance increases the sensitivity, as for texturing the surface, the sensitivity quality factor (Q)?=?236 and figure of merit (FOM)?=?170. For sawtooth surfaces, Q?=?272.4, and FOM?=?199. The consequences of structural parameters on the efficiency of sensing are studied, and new procedures are proposed to enhance TPP-based sensors. A simple and functional alternative to conventional salinity sensors may be the proposed solution.
Mammalian Genome - Neurodegenerative disease encompasses a wide range of disorders afflicting the central and peripheral nervous systems and is a major unmet biomedical need of our time. There are... 相似文献
A group of 4-allyloxyaniline amides 5a–o were designed, synthesized and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO) on the basis of eugenol and esteragol structures. Compound 5e showed the best IC50 in SLO inhibition (IC50 = 0.67 ± 0.06 μM). All compounds were docked in SLO active site retrieved from RCSB Protein Data Bank (PDB entry: 1IK3) and showed that allyloxy group of compounds is oriented towards the Fe3+-OH moiety in the active site of enzyme and fixed by hydrogen bonding with two conserved His513 and Gln716. It is resulted that molecular volume of the amide moiety would be a major factor in inhibitory potency variation of the synthetic amides, where the hydrogen bonding of the amide group could also involve in the activity of the inhibitors. 相似文献
Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J ( 1 ). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7 % at 25 μg/mL. 相似文献
Biomechanics and Modeling in Mechanobiology - The bronchial tree plays a main role in the human respiratory system because the air distribution throughout the lungs and gas exchange with blood... 相似文献
The DNA polymerase I gene of a newly described deep-sea hydrothermal vent Archaea species, Thermococcus fumicolans, from IFREMERS's collection of hyperthermophiles has been cloned in Escherichia coli. As in Thermococcus litoralis, the gene is split by two intervening sequences (IVS) encoding inteins inserted in sites A and C of family B DNA polymerases.
The entire DNA polymerase gene, containing both inteins, was expressed at 30°C in E. coli strain BL21(DE3)pLysS using the pARHS2 expression vector. The native polypeptide precursor of 170 kDa was obtained, and intein
splicing as well as ligation of the three exteins was observed in vitro after heat exposure. The recombinant enzyme was purified
and some of its activities were characterized: polymerization, thermostability, exonuclease activities, and fidelity.
Received: September 17, 1999 / Accepted: March 21, 2000 相似文献