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排序方式: 共有141条查询结果,搜索用时 15 毫秒
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R B Zeidler N S Conley 《Comparative biochemistry and physiology. B, Comparative biochemistry》1986,85(1):101-104
Pig alveolar macrophages generate superoxide anions at a rate of 1.8 nanomoles/1 X 10(6) cells/min. The intracellular value of ATP in resting cells was 4.0 +/- 0.1 X 10(-16) mole/cell; in contrast the value in cells generating superoxide anions was 2.0 +/- 0.6. Superoxide generation was increasingly inhibited by exposing cells to adenosine from 0.1 to 1.0 mM. Unlike human macrophages, pig cell production of superoxide anions was not inhibited by exposure to the adenosine analog, 2-Cl-adenosine. 相似文献
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Bozenna Golankiewicz Joanna Zeidler Erik De Clercq 《Nucleosides, nucleotides & nucleic acids》2013,32(4):663-678
Abstract C-acyclic nucleoside analogues of inosine and guanosine 8-[(RS)-2,3-dihydroxypropyl] imidazo [1,5-a]-1,3,5-triazin-4 (3H)-ones 6a, c, d were synthesized. The route involved the cyclization-rearrangement of 5-acylamino-5-allyl-6-amino-4,5-dihydropyrimidin-4-ones 4a-c to 8-allylimidazo [1,5-a]-1,3,5-triazin-4 (3H) ones 5a-c. 5a was transformed selectively into 5d by reductive desulfurization with highly deactivated Raney nickel. The poorly soluble compounds 5b and 5c were converted to N-2-acetylated 5f and 5g. Osmium tetroxide hydroxylation of 5d, f, g gave 6a, c, d. None of the newly synthesized C-acyclic nucleoside derivatives showed an appreciable antiviral or antitumor cell activity. 相似文献
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Chiara Testa Anna Maria Papini Reinhard Zeidler Daniela Vullo Fabrizio Carta Claudiu T. Supuran Paolo Rovero 《Journal of enzyme inhibition and medicinal chemistry》2022,37(1):592
We report for the first time Antibody-Drug-Conjugates (ADCs) containing human (h) Carbonic Anhydrase (CA; EC 4.2.1.1) directed Monoclonal Antibodies (MAbs) linked to low molecular weight inhibitors of the same enzymes by means of hydrophilic peptide spacers. In agreement with the incorporated CA directed MAb fragments, in vitro inhibition data of the obtained ADCs showed sub-nanomolar KI values for the tumour associated CAs IX and XII which were up to 10-fold more potent when compared to the corresponding unconjugated MAbs. In addition, the introduction of the CA inhibitor (CAI) benzenesulfonamide allowed the ADCs to potently inhibit the housekeeping tumoral off-target human CA II isoform. Such results are supporting the definition of an unprecedented reported class of ADCs able to hit simultaneously multiple hCAs physiologically cooperative in maintaining altered cellular metabolic pathways, and therefore ideal for the treatment of chronic diseases such as cancers and inflammation diseases. 相似文献
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Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival. 总被引:9,自引:2,他引:9 下载免费PDF全文
U Zimber-Strobl B Kempkes G Marschall R Zeidler C Van Kooten J Banchereau G W Bornkamm W Hammerschmidt 《The EMBO journal》1996,15(24):7070-7078
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