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51.
A 36-year-old man suffering from chronic myeloid leukemia (in chronic phase) was initially treated with busulphan. At the
end of 6 months of follow-up he developed bone marrow aplasia. He was given single foetal liver infusion therapy. The patient
recovered fully from aplasia. He continued in chronic phase for more than 7 years with intermittent busulphan therapy. 相似文献
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Sudhanshu Sudan HP Vasantha Rupasinghe 《Experimental biology and medicine (Maywood, N.J.)》2015,240(11):1452-1464
Despite their strong role in human health, poor bioavailability of flavonoids limits their biological effects in vivo. Enzymatically catalyzed acylation of fatty acids to flavonoids is one of the approaches of increasing cellular permeability and hence, biological activities. In this study, six long chain fatty acid esters of quercetin-3-O-glucoside (Q3G) acylated enzymatically and were used for determining their antiproliferative action in hepatocellular carcinoma cells (HepG2) in comparison to precursor compounds and two chemotherapy drugs (Sorafenib and Cisplatin). Fatty acid esters of Q3G showed significant inhibition of HepG2 cell proliferation by 85 to 90% after 6 h and 24 h of treatment, respectively. The cell death due to these novel compounds was associated with cell-cycle arrest in S-phase and apoptosis observed by DNA fragmentation, fluorescent microscopy and elevated caspase-3 activity and strong DNA topoisomerase II inhibition. Interestingly, Q3G esters showed significantly low toxicity to normal liver cells than Sorafenib (P < 0.05), a chemotherapy drug for hepatocellular carcinoma. Among all, oleic acid ester of Q3G displayed the greatest antiproliferation action and a high potential as an anti-cancer therapeutic. Overall, the results of the study suggest strong antiproliferative action of these novel food-derived compounds in treatment of cancer. 相似文献
54.
P W Anderson M E Pichichero E C Stein S Porcelli R F Betts D M Connuck D Korones R A Insel J M Zahradnik R Eby 《Journal of immunology (Baltimore, Md. : 1950)》1989,142(7):2464-2468
Vaccines consisting of oligosaccharide (OS) derived from Haemophilus influenzae type b capsular polysaccharide and conjugated to carrier proteins had been shown capable of eliciting memory-type capsular polysaccharide of H. influenza type b antibody responses in human infants, but the structural variables governing immunogenicity were not defined. Here a series of conjugates were made with the diphtheria protein CRM197 and with uniterminally coupled OS haptens that varied in chain length, exposed terminal residue, or multiplicity of loading as defined by ribose/protein ratio. Adults were given a single injection, 1-yr-old infants were given a two-injection sequence, and capsular polysaccharide of H. influenzae type b antibody responses were assessed by radioantigen binding. Vaccines C-4r, C-6r, and C-12r, in which ribitol-ended OS of mean length 4, 6, or 12 repeat units were coupled at low hapten loading, were about equally immunogenic (geometric means 2 to 5 micrograms/ml in infants, 5 to 9 micrograms/ml in adults). Vaccine C7p was made with a higher loading of OS having mean length 7 repeat units and having mainly phosphate monoester at the exposed termini Vaccine C-7R was made from a portion of C-7p by enzymatic removal of most of the terminal phosphates. Compared to the C-4r, C-6r, and C-12r series, vaccines C-7p and C-7R induced geometric means about 10-fold higher in adults and 20-fold higher in infants. Thus OS chain length (in the range studied) and exposed terminus are less critical variables in this system than the extent of hapten loading. 相似文献
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Chihiro Motozono Mako Toyoda Jiri Zahradnik Akatsuki Saito Hesham Nasser Toong Seng Tan Isaac Ngare Izumi Kimura Keiya Uriu Yusuke Kosugi Yuan Yue Ryo Shimizu Jumpei Ito Shiho Torii Akiko Yonekawa Nobuyuki Shimono Yoji Nagasaki Rumi Minami Kei Sato 《Cell host & microbe》2021,29(7):1124-1136.e11
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