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1.
Zagrodzki Paweł Mietelski Jerzy W. Krośniak Mirosław Petelenz Barbara 《Biological trace element research》1994,(1):273-277
The aim of this work was to check whether the stable cesium content in forest litter affects the value of radiocesium from
litter-to-mushroom transfer factorTf or not. Total cesium in litter, measured by AAS, varied from 0.1–2.7 μg/g. These data, combined with earlier results for
mushrooms, showed no simple correlation forTf. More complex relationships provided very high correlation coefficients, but their validity needs further investigation. 相似文献
2.
Zbigniew Szybiński Stanisław Walas Paweł Zagrodzki Grzegorz Sokołowski Filip Gołkowski Halina Mrowiec 《Biological trace element research》2010,138(1-3):28-41
The purpose of this work was to determine trace element levels in urine and evaluate possible associations between urinary iodine concentration (UIC), other trace elements (Cr, Cu, Fe, Mn, Na, Se, Zn), toxic elements (Cd, Pb), anthropometrical measures (body weight and height), glycemic indices (serum insulin and glucose), and several parameters related to thyroid function (thyroid stimulating hormone, free thyroxine, antithyroid peroxidase antibodies, thyroid volume, and thyroid echogenicity) in pregnant women. One hundred sixty-nine participants were recruited. The whole study group, originating from Krakow region, comprised three subgroups belonging to three trimesters: I trimester (n?=?28), II trimester (n?=?83), and III trimester (n?=?58). Trace elements were determined using inductively coupled plasma mass/(atomic emission) spectrometry. Partial least square model was used to reveal correlation structure between parameters investigated, as well as a possible causal relationship between dependent parameters and potentially explanatory parameters. Results obtained for trace and toxic elements in urine were comparable with results of other authors, although the study group was not homogenous. We confirmed (1) low iodine excretion in pregnant women, (2) the existence of statistically significant correlation between UIC and urinary selenium, and (3) lack of correlation between latter parameter and typical indices of thyroid function. Urinary selenium correlated with other urinary trace elements, but physiological significance of this finding remains uncertain. The fact that a large number of pregnant women fail to meet dietary recommendations for iodine is the major reason for concern. 相似文献
3.
Recently published biochemical data suggest the significant role of selenium compounds as the adjuvants combined with L: -thyroxine therapy, which can reduce antithyroid peroxidase antibodies' (TPOAb) levels in patients with Hashimoto disease. The study was undertaken to document in a more detailed way the changes in parameters expressing the thyroid and ovarian function brought about by selenium supplementation (50-100 microg/day) in a woman undergoing autoimmune thyroiditis (AIT) therapy. This prospective observational case study lasted for 14 months plus additional 5 months as a follow-up period. Parameters reflecting selenium status, thyroid metabolism, and sex hormones secretion were determined at the onset and end of the study period, as well as in some of its middle points. During the supplementation trial, serum selenium (Se) increased by 45% and plasma glutathione peroxidase (GPX3) by 21%. TPOAb decreased by 76%. All other parameters also fluctuated during the supplementation period, but all results were always within normal physiological ranges. After withdrawal of the supplementation, the sharp fall of Se and GPX3 promptly occurred, and this phenomenon was accompanied with a marked increase in TPOAb. This report stresses the importance of selenium supplementation in AIT treatment. However, the efficiency and durability of the effect of Se supplementation on the TPOAb titer remain an open question. The clarification of mechanism(s) underlying Se interaction with autoimmune processes should throw new light on this issue. 相似文献
4.
Z. Zachwieja J. Chlopicka M. Schlegel-Zawadzka P. Zagrodzki J. Wypchlo M. Krośniak 《Biological trace element research》1995,47(1-3):141-145
The zinc content in the hair of 654 children living in various rural and industrial areas in southern Poland was assayed by
means of the atomic absorption spectrometry, following the dry digestion procedure. The hair of girls exhibited statistically
significant higher level of Zn than the boys’ hair, although in the site of extremal Zn contamination, the inverse relation
was found. 相似文献
5.
Elwira Przybylik-Mazurek Paweł Zagrodzki Sylwia Kuźniarz-Rymarz Alicja Hubalewska-Dydejczyk 《Biological trace element research》2011,141(1-3):65-75
The trace elements studied in this work (Se, Cu, Zn) are the essential constituents or cofactors required to activate numerous enzymes and proteins, playing crucial role in various physiological processes. The disturbed levels of abovementioned elements may adversely affect the endocrine system, resulting in various thyroid disorders among other upsets. The aim of this study was to investigate possible associations between them and parameters of redox balance, thyroid function indices as well as clinical records (duration of disease and therapy, lag time between thyroid surgery and this study examination, LT4 dosage) in patients with different thyroid disorders, including malignant diseases of the gland. In the group of patients with papillary carcinoma, we found a statistically significant higher Cu concentration compared with controls and patients with Hashimoto disease. In the same groups, the parameter of Zn/Cu ratio demonstrated reciprocally arranged statistically significant differences. For the group of papillary cancer patients, there was a negative correlation between lag time since thyroid operation and GPX3 activity. Our data support hypothesis of indirect involvement of Zn and Cu in thyroid regulation. For selenium, lack of simple correlation between its serum level and thyroid indices implies the need for further research on other selenium status parameters more adequately depicting changes in endocrine system. 相似文献
6.
Brudecki K. Kluczewska-Gałka A. Zagrodzki P. Jarząb B. Gorzkiewicz K. Mróz T. 《Radiation and environmental biophysics》2020,59(3):559-564
Radiation and Environmental Biophysics - The main goal of the present study was estimation of an internal contamination of 131I among family members of patients treated with radioactive iodine.... 相似文献
7.
Zagrodzki P Bartoń H Walas S Fołta M Stompór T Janusz-Grzybowska E Drozdz M Sułowicz W 《Biological trace element research》2007,116(1):29-41
We investigated the relations between selenium status (SeS) parameters, indexes of nutrition, erythropoiesis, and uremic toxemia,
serum electrolytes, and other biochemical markers in end-stage renal disease (ESRD) patients, as no multivariate statistical
analysis concerning all of these parameters was performed so far. SeS was evaluated by plasma Se concentration (plSe) and
glutathione peroxidase (plGSHPx) activity in 69 uremic patients treated with hemodialysis (HD) and 40 healthy controls. The
hierarchical multivariate partial least squares model (PLS2) was employed to establish data structure and correlations between
parameters investigated. plSe and plGSHPx activity were significantly lower in patients when compared with controls (p=0.000). plSe was positively associated with indexes of erythropoiesis and nutritional status, as well as serum electrolytes
and parameters of uremic toxemia. plGSHPx was inversely dependent on the pair of parameters: intact parathyroid hormone (iPTH)
and aluminum plasma concentration (Al). We conclude that (1) ESRD strongly decreases selenium status and (2) the PLS2 approach
revealed the existence of significant interactions among plSe, plGSHPx, and selected biochemical parameters or groups of such
parameters; some of these associations need further studies to be clarified. 相似文献
8.
The objective of the present work was to study all physiological relationships among selenium status (SeS), sex hormones secretion
(SH), and thyroid metabolism (ThM) in healthy adolescent girls, at one time. Forty-four girls aged 13.4–16.6 years (mean age,
14.5 ± 0.5 years) entered the statistical model. Parameters reflecting SeS: plasma selenium concentration (Se) and plasma
glutathione peroxidase activity (GPX3); SH: serum estradiol (E2) and progesterone (P4); age of menarche (AoM); and ThM: thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), antithyroid
peroxidase antibodies (anti-TPO) in serum, and thyroid volume (ThV), were determined, and the interactions between them were
evaluated by means of the partial least squares method (PLS). PLS method was, for the first time, successfully applied to
the problem of selenium and hormone interactions and revealed that selenium status and female reproductive system are interrelated
and affect thyroid physiology in adolescent girls in the luteal phase. The strongest associations were revealed for the pairs
of parameters, Se and fT4/fT3, Se and P4, the modest ones for the pairs, Se and ThV, P4 and fT4/fT3, Se and AoM, and P4 and AoM. There was no correlation between E2, GPX3, and TSH, and any other considered parameter. Se and P4 had the greatest influence on ThM parameters. 相似文献
9.
Paśko Paweł Prochownik Ewelina Krośniak Mirosław Tyszka-Czochara Małgorzata Francik Renata Marcinkowska Monika Sikora Jakub Malinowski Mateusz Zagrodzki Paweł 《Biological trace element research》2020,193(1):204-213
Biological Trace Element Research - The study was primarily aimed at investigating the effect of brassica sprout consumption, namely rutabaga (Brassica napus L. var. napobrassica) sprouts (R)... 相似文献
10.
Antioxidants activities and concentration of selenium,zinc and copper in preterm and IUGR human placentas 总被引:1,自引:0,他引:1
Monika Zadrożna Małgorzata Gawlik Barbara Nowak Antoni Marcinek Halina Mrowiec Stanisław Walas Renata Wietecha-Posłuszny Paweł Zagrodzki 《Journal of trace elements in medicine and biology》2009,23(2):144-148
The aim of this study was to examine changes in activities of cytochrome c oxidase (CCO), glucose-6-phosphate dehydrogenase (G6PDH), Cu–Zn superoxide dismutase (Cu–Zn SOD), glutathione peroxidase (GSH-Px), glutathione (GSH) levels and copper (Cu), zinc (Zn) and selenium (Se) concentrations, and to assess the possible differences between preterm placentas, placentas from term pregnancies complicated by intrauterine growth restriction (IUGR) and full-term control placentas.The enzyme activities and the level of GSH decreased in IUGR and preterm placentas in comparison with the control group. CCO activity and GSH level in preterm placentas were markedly lower compared with the IUGR (P<0.01; P<0.05) and control (P<0.01; P<0.05) placentas, respectively. In IUGR placentas the level of Cu was reduced by 23% (P<0.05) and Zn by 37%. In preterm placentas the level of Cu was reduced by 19% and Zn by 42%. Se level in IUGR and preterm placentas was higher (P<0.05) by 28% and 32% than in control group, respectively. The strong relation was observed between birth weight and CCO activity, birth weight and Cu–Zn SOD activity, and a low level of Zn and Cu influenced the birth weight especially in IUGR cases. Moreover, the strong inverse correlation between Se level and birth weight, Se level and placental weight and Se level and CCO activity are new findings. 相似文献