Adenosine triphosphate (ATP) and its metabolites adenosine diphosphate, adenosine monophosphate, and adenosine in purinergic signaling pathway play important roles in many diseases. Activation of P2 receptors (P2R) channels and subsequent membrane depolarization can induce accumulation of extracellular ATP, and furtherly cause kinds of diseases, such as pain- and immune-related diseases, cardiac dysfunction, and tumorigenesis. Active ingredients of traditional Chinese herbals which exhibit superior pharmacological activities on diversified P2R channels have been considered as an alternative strategy of disease treatment. Experimental evidence of potential ingredients in Chinese herbs targeting P2R and their pharmacological activities were outlined in the study.
Russian Journal of Bioorganic Chemistry - The grape is a highly valuable food stuff owing to the presence of a number of biologically active substances, and vitamins occupy a special place among... 相似文献
In 2010–2011, experimental commercial cultivation of 14 species of hermatypic corals was carried out using the method of donor colony fragmentation. The transplants successfully survived on experimental frame installations. The coral colonies that were recovered from the fragments became attached to the frame installations in a similar way to their attachment on natural substrata. After 1 year, the size of the trans-plants was found to have increased by 275%. The newly formed artificial coral community was colonized by the damselfish Dascyllus reticulates (Pomacentridae); the species is a common coral fish species that lives on natural reefs. 相似文献
In July 2010, abnormally high water temperature (25–29°C), as well as increased biomass and phytoplankton production caused intensive development of heterotrophic bacteria and heterotrophic nanoflagellates. It was found that the abundance, biomass, and production of heterotrophic bacterioplankton, as well as the abundance and biomass of heterotrophic nanoflagellates, and the number of planktonic viruses, which were calculated on average for the reservoir under study, turned out to be higher in the years with lower water temperature (20–23°C). The virus-induced mortality of bacterioplankton in the Oka River and the Cheboksary Reservoir averaged 25.4 ± 3.4 and 22.4 ± 2.7% of the daily bacterioplankton production. 相似文献