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排序方式: 共有134条查询结果,搜索用时 390 毫秒
41.
Asim Kadioglu Neslihan Saruhan Aykut Sağlam Rabiye Terzi Tuba Acet 《Plant Growth Regulation》2011,64(1):27-37
Salicylic acid (SA) is one of the important signal molecules modulating plant responses to environmental stress. In this study,
the effects of exogenous SA on leaf rolling, one of drought avoidance mechanisms, and antioxidant system were investigated
in Ctenanthe setosa during long term drought stress. The plants were subjected to 38-day drought period and they were treated with or without
SA (10−6 M) on the 25th, 27th and 29th days of the period. Leaf samples were harvested on the 30th, 34th and 38th days. Some antioxidant
enzyme activities (superoxide dismutase, catalase, ascorbate peroxidase, dehydroascorbate reductase, monodehydroascorbate
reductase, glutathione reductase), reactive oxygen species (hydrogen peroxide and superoxide) and lipid peroxidation were
determined during the drought period. Treatment with SA prevented water loss and delayed leaf rolling in comparison with control
leaves. Exogenous SA induced all antioxidant enzyme activities more than control leaves during the drought. Ascorbate and
glutathione, α-tocopherol, carotenoid and endogenous SA level were induced by the SA treatment. Levels of reactive oxygen
species were higher in SA treated plants than control ones on the 34th day. Their levels on the 38th day, however, fastly
decreased in SA treated plants. SA treatment prevented lipid peroxidation while the peroxidation increased in control plants.
The results showed that exogenous SA can alleviate the damaging effect of long term drought stress by decreasing water loss
and inducing the antioxidant system in the plant having leaf rolling, alternative protection mechanism to drought. 相似文献
42.
Shirinzadeh H Altanlar N Yucel N Ozden S Suzen S 《Zeitschrift für Naturforschung. C, Journal of biosciences》2011,66(7-8):340-344
There has been an increasing importance of drug-resistant pathogens in clinical microbiological and antibacterial research. Indoles and hydrazone-type compounds constitute important classes of compounds in the search for effective agents against multidrug-resistant microbial infections. In this study a series of 1-methylindole-3-carboxaldehyde hydrazone derivatives were evaluated for their in vitro antimicrobial activities using the two-fold serial dilution technique against Staphylococcus aureus, methicillin-resistant S. aureus, methicillin-resistant S. aureus isolate, Escherichia coli, Bacillus subtilis, and Candida albicans. The minimum inhibitory concentration (MIC) of the test compounds and the reference standards sultamicillin, ampicillin, fluconazole, and ciprofloxacin was determined. All compounds possessed a broad spectrum of activity having MIC values of 6.25-100 microg/ml against the tested microorganisms. Aromaticity and disubstitution of the phenyl ring with especially fluorine and chlorine atoms were found to be significant for the antimicrobial activity 相似文献
43.
Daniel R. Neill Vitor E. Fernandes Laura Wisby Andrew R. Haynes Daniela M. Ferreira Ameera Laher Natalie Strickland Stephen B. Gordon Paul Denny Aras Kadioglu Peter W. Andrew 《PLoS pathogens》2012,8(4)
Streptococcus pneumoniae is an important human pathogen responsible for a spectrum of diseases including pneumonia. Immunological and pro-inflammatory processes induced in the lung during pneumococcal infection are well documented, but little is known about the role played by immunoregulatory cells and cytokines in the control of such responses. We demonstrate considerable differences in the immunomodulatory cytokine transforming growth factor (TGF)-β between the pneumococcal pneumonia resistant BALB/c and susceptible CBA/Ca mouse strains. Immunohistochemistry and flow cytometry reveal higher levels of TGF-β protein in BALB/c lungs during pneumococcal pneumonia that correlates with a rapid rise in lung Foxp3+Helios+ T regulatory cells. These cells have protective functions during pneumococcal pneumonia, because blocking their induction with an inhibitor of TGF-β impairs BALB/c resistance to infection and aids bacterial dissemination from lungs. Conversely, adoptive transfer of T regulatory cells to CBA/Ca mice, prior to infection, prolongs survival and decreases bacterial dissemination from lungs to blood. Importantly, strong T regulatory cell responses also correlate with disease-resistance in outbred MF1 mice, confirming the importance of immunoregulatory cells in controlling protective responses to the pneumococcus. This study provides exciting new evidence for the importance of immunomodulation during pulmonary pneumococcal infection and suggests that TGF-β signalling is a potential target for immunotherapy or drug design. 相似文献
44.
Cardiovascular disease (CVD) is closely associated with familial predisposition. The aim of the present study was to investigate
predisposing risk factors in the family of a young patient who underwent coronary artery bypass graft surgery due to CVD.
The father and uncle of the patient died at an early age due to myocardial infarction. Various stages of CVD were identified
in both of the patient’s brothers (28 and 32 years of age). Biochemical tests (fasting blood glucose, lipid profile, urea,
creatinine and liver enzymes) and a complete blood count (haemoglobin, haematocrit, white blood cell count, and platelet count)
were performed. Physiological coagulation inhibitory factors (protein C, protein S, and antithrombin III), prothrombotic genetic
risk factors (factor V Leiden, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase A1C and C6T, angiotensin-converting
enzyme, β-fibrinogen, glycoprotein IIIa and factor XIII) and homocysteine levels were evaluated in all cases. Defects were
observed in many genetic factors and in the systems regulated by these factors. The results were compatible with those reported
in the literature. In conclusion, it is possible to determine a specific family history in young adults with CVD. From this
perspective, the emergence of more serious CVD may be prevented by providing disease-related information to the other family
members and implementing preventive measures. 相似文献
45.
Decolorization of sugar syrups using commercial and sugar beet pulp based activated carbons 总被引:2,自引:0,他引:2
Sugar syrup decolorization was studied using two commercial and eight beet pulp based activated carbons. In an attempt to relate decolorizing performances to other characteristics, surface areas, pore volumes, bulk densities and ash contents of the carbons in the powdered form; pH and electrical conductivities of their suspensions and their color adsorption properties from iodine and molasses solution were determined. The color removal capabilities of all carbons were measured at 1/100 (w/w) dosage, and isotherms were determined on better samples. The two commercial activated carbons showed different decolorization efficiencies; which could be related to their physical and chemical properties. The decolorization efficiency of beet pulp carbon prepared at 750 degrees C and activated for 5h using CO2 was much better than the others and close to the better one of the commercial activated carbons used. It is evident that beet pulp is an inexpensive potential precursor for activated carbons for use in sugar refining. 相似文献
46.
47.
Tayfun Kasikci Semai Bek Guray Koc Mehmet Yucel Yasar Kutukcu Zeki Odabasi 《Somatosensory & motor research》2017,34(4):235-241
Objectives: Detecting whether a possible disequilibrium between the excitatory and inhibitory interhemispheric interactions in paroxysmal kinesigenic dyskinesia (PKD) exists.Methods: This study assessed measures of motor threshold, motor evoked potential latency, the cortical silent period, the ipsilateral silent period and the transcallosal conduction time (TCT) in PKD patients. Data were compared between the clinically affected hemisphere (aH) and the fellow hemisphere (fH).Results: The transcallosal conduction time from the aH to the fH was 11.8?ms (range?=?2.3–20.7) and 13.6?ms (range?=?2.8–67.7) from the fH to the aH. The difference in TCT in the affected side was significant (p?=?.019).Conclusion: The findings demonstrated that, although inhibitory interneurons act normally and symmetrically between the motor cortices and transcallosal inhibition was normal and symmetrical between both sides, the onset of transcallosal inhibition was asymmetrical. The affected hemisphere’s inhibition toward the unaffected hemisphere is faster compared to the inhibition provided by the fellow hemisphere. These results are consistent with an inhibitory deficit in the level of interhemispheric interactions.Significance: This study revealed a defect in inhibition of the motor axis could be responsible in the pathological mechanisms of kinesigenic dyskinesia. 相似文献
48.
Branching patterns of rabbit oculomotor and trochlear nerves demonstrated by Sihler's stain technique 总被引:1,自引:0,他引:1
R. G zil D. Kadioglu E. Calgü ner D. Erdogan M. Bahcelioglu C. Elmas 《Biotechnic & histochemistry》2002,77(1):21-25
A modified Sihler's stain technique was used to visualize the branching patterns of oculomotor and trochlear nerves. The levator palpebrae, superior rectus, inferior rectus, medial rectus, inferior oblique, superior oblique and tensor trochlea muscles were isolated from the eyes of normal rabbits and processed using modified Sihler's technique. The distributions and terminal ramifications of the oculomotor and trochlear nerves were observed. Two distinct divisions and terminal branches of the oculomotor nerve were shown in detail together with the trochlear nerve distribution. The application of Sihler's technique enables researchers to trace nerve branching within relatively transparent muscles, whereas the nerve fibers are counterstained and clearly visible. This technique could be useful for detailed studies of the motor control of extraocular muscles. 相似文献
49.
Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts 总被引:2,自引:0,他引:2
Kerr AR Kirkham LA Kadioglu A Andrew PW Garside P Thompson H Mitchell TJ 《Microbes and infection / Institut Pasteur》2005,7(5-6):845-852
Gram-positive sepsis is a major disease problem. However, the contribution of various immune cell types to pathogenesis remains unclear. By infecting scid and wild type BALB/c mice with Streptococcus pneumoniae we have found a situation in which natural killer (NK) cells can play a detrimental role in the response to infection. scid mice were found to be significantly more susceptible to local and systemic pneumococcal infection than controls; they had significantly higher bacterial loads, elevated inflammatory responses and more widespread lung pathology. Interestingly, depletion of NK cells in scid mice resulted in significantly lower bacteraemia and inflammatory cytokine production. Infection with pneumococci deficient in pneumolysin revealed the toxin was involved in cytokine production. Overall results indicate that elevated NK cell activity during pneumococcal pneumonia amplifies pulmonary and systemic inflammation, increases bacteraemia and results in poor outcome. 相似文献
50.