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131.
Mutay Aslan Gultekin Yucel Hakan Bozcuk Burhan Savas 《Cancer immunology, immunotherapy : CII》1998,47(3):176-181
Secondary infections related to neutropenia and functional defects of phagocytes are common consequences in patients treated
for cancer. The hematopoietic colony-stimulating factors (CSF) have been introduced into clinical practice as additional supportive
measures that can reduce the incidence of infectious complications in patients with cancer and neutropenia. The aim of this
study was to determine the role of␣granuolcyte/macrophage(GM)-CSF and granulocyte(G)-CSF in enhancing in vivo human neutrophil
function. A luminol-dependent chemiluminescence assay was developed to evaluate whether the repair in neutropenia accompanies
the ability of neutrophils to function. A dose of 5 μg G-CSF kg−1 day−1 [recombinant human (rHu) G-CSF; filgrastim] or 250 μg GM-CSF m−2 day−1 (rHu GM-CSF; molgramostim) was administered subcutaneously once daily to 12 metastatic cancer patients being treated with
different cytotoxic regimens. All injections of CSF were given after the initiation of neutropenia and continued until the
occurrence of an absolute neutrophil recovery. rHu GM-CSF and rHu G-CSF, administered once daily at the 250 μg m−2 day−1 and 5 μg kg−1 day−1 level, were effective in increasing the absolute neutrophil count and neutrophil function, as measured by an automated chemiluminescence
system.
Received: 26 February 1998 / Accepted: 21 May 1998 相似文献
132.
Cigdem Yucel Falco Federico Amadei Surender K. Dhayal Marité Cárdenas Motomu Tanaka Jens Risbo 《Biotechnology progress》2019,35(3):e2806
A hybrid coating based on multilayers of proteins and biopolymers was developed to enhance the protection performance of alginate microbeads against acidic conditions for delivery of probiotics (Lactobacillus rhamnosus GG). Zeta potential measurements and quartz crystal microbalance with dissipation confirmed layer-by-layer deposition of protein-polymer layers. The stability of protein-based coatings during simulated gastric fluid (SGF) treatment was monitored by microscopy. Protein-coated microbeads were partially dismantled, whereas polymer-coated microbeads were intact after a sequential treatment in simulated gastric and intestinal fluids. This suggests that hybrid formulation offers an advantage over the coatings based on biopolymer multilayers in terms of better release of bacteria. Uncoated alginate microbeads completely dissolved and could not protect bacteria after SGF treatment whereas microbeads with hybrid coating showed increased physical stability and a modest decrease of culturability of 3.8 log units. Therefore, this work provides a concept for future protein-based hybrid coatings for bacterial delivery systems. 相似文献
133.
The effects of drought, temperature and irradiation on leaf rolling of Ctenanthe setosa were studied. Water deficit and air
temperature were the most important, and have a synergistic effect on the degree and number of the rolled leaves. Irradiation
also increased the rolling together with the water deficit but not alone. The stomata were open in rolled leaves.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
134.
Kamil Ozturk Aykut Saglam Asm Kadioglu 《Physiology and Molecular Biology of Plants》2020,26(3):525-535
To understand high temperature tolerance, Heliotropium thermophilum, a flowering plant thriving in a geothermal field with a soil temperature ranging between 55 and 65 °C, was grown in controlled laboratory conditions and two different soil temperatures were applied to the plants. One of them was the control group (CT 25 ± 3 °C) and the other was the high temperature group (HT 60 ± 4 °C). Water potential, dry weight, cell membrane injury (CMI), lipid peroxidation, hydrogen peroxide, chlorophylls, carotenoids, flavonoids, anthocyanins, proline and total soluble sugar contents were measured. Contents of total soluble sugars, phenolics, flavonoids, anthocyanins, proline were found to be higher in HT group than CT while CMI was opposite. Moreover, no difference was determined in water potential, dry weight, lipid peroxidation, total chlorophyll and carotenoids between CT and HT. H. thermophilum plants adapted to high temperature under laboratory conditions through changing membrane lipid saturation, accumulating osmotically active compounds to save water or increase its uptake and inducing antioxidants such as phenolic compounds to keep reactive oxygen species under control. In conclusion, this study showed that H. thermophilum plant was highly resistant to high soil temperature under optimized laboratory conditions. Moreover, a plant that can withstand 60 °C for a long period of time up to 60 days under laboratory conditions was reported for the first time. 相似文献