The response of generalized motor activation in man

The effect of short acoustic and photic stimuli on the magnitude of the T- and H-reflexes was investigated in man. Two periods of increase in the amplitude and dispersion of the two test reflexes, disappearing during repetition of the stimulation, were found. Its first component differs from the second in the greater change in the T-reflex and the smaller extinction. The pattern of changes after photic and acoustic stimulation was the same but acoustic evoked a stronger response. The changes discovered are a subthreshold manifestation of the generalized response of motor activation evoked by a wide range of stimuli. It is postulated that its first component is determined by interaction between pyramidal impulses and the motor cortex and the second is due to the efferent volley from the primary cortical projection zones through the reticulo-spinal tract.     

Flow through a Collapsible Tube: Experimental Analysis and Mathematical Model

Flow through thin-wall axisymmetric tubes has long been of interest to physiologists. Analysis is complicated by the fact that such tubes will collapse when the transmural pressure (internal minus external pressure) is near zero. Because of the absence of any body of related knowledge in other sciences or engineering, previous workers have directed their efforts towards experimental studies of flow in collapsible tubes. More recently, some attention has been given towards analytical studies. Results of an extensive series of experiments show that the significant system parameter is transmural pressure. The cross-sectional area of the tube depends upon the transmural pressure, and changes in cross-section in turn affect the flow geometry. Based on experimental studies, a lumped parameter system model is proposed for the collapsible tube. The mathematical model is simulated on a hybrid computer. Experimental data were used to define the functional relationship between cross-sectional area and transmural pressure as well as the relation between the energy loss coefficient and cross-sectional area. Computer results confirm the validity of the model for both steady and transient flow conditions.     

Potentials of spinal motoneurons in cats with experimental tetanus

Potentials of motoneurons of the lower segments of the spinal cord were recorded with the aid of intracellular microelectrodes in experiments on cats with induced tetanus produced by injection of tetanus toxin (1500–2000 mouse LD₅₀) into the extensor muscles of the left shin. Neither afferent volleys of impulses in cutaneous and muscle nerves, nor antidromic volleys in the corresponding ventral roots, produced IPSPs in motoneurons of the extremity into which toxin was injected. The form both of antidromic peak potentials and of monosynaptic EPSPs in motoneurons in which IPSPs were blocked by tetanus toxin did not differ from the form of corresponding potentials of motoneurons in normal cats. The values of threshold depolarization for peak discharges during synaptic and direct stimulation were equal in tetanus and control motoneurons. Resistance and time constant values of the membrane in "tetanus" motoneurons did not differ from the corresponding values for "control" motoneurons.N. I. Pirogov Second Medical Institute, Moscow. Translated from Neirofiziologiya, Vol. 1, No. 1, pp. 25–34, July–August, 1969.     

Corticofugal influences on neurons of the main trigeminal sensory nucleus

The effects of stimulation of the ipsilateral sensomotor cortex were studied on 88 neurons in the region of the main trigeminal sensory nucleus of a cat. The cortex was stimulated via a coaxial electrode by single impulses. Stimulation of the cortex caused the appearance of EPSPs and action potentials in these neurons; a small number of these responses were monosynaptic. The polarity of the impulse applied to the cortex had a significant effect on the magnitude of the latent period of the response and the postsynaptic reaction, which is apparently caused by the stimulation of different types of cortex neurons. Apparently, corticofugal pulsation regulates the level of sensitivity of the trigeminal sensory neurons.A. A. Bogomolets' Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 1, No. 1, pp. 47–53, July–August, 1969.     

猪-C反应蛋白的分离纯化及其性质的研究

以猪血清为材料,通过磷酸乙醇胺—琼脂糖亲和层析,Sepharose 4B柱层析和Sephacryl—S300凝胶过滤,获得了猪C—反应蛋白的结晶。猪C—反应蛋白可与肺炎球菌壁C多糖发生特异的沉淀反应,这种结合是依赖钙离子的。EDTA和一些磷脂代谢产物如磷酸胆碱,磷酸乙醇胺等,能抑制猪C—反应蛋白与C多糖的结合。在SDS—聚丙烯酰胺凝胶电泳及梯度聚丙烯酰胺凝胶电泳中,猪C—反应蛋白表现出与人C—反应蛋白相同的行为,亚基是一条分子量为23.5kD的肽链,全分子的表观分子量为150kD。猪C—反应蛋白与兔抗人C—反应的蛋白的抗血清能发生免疫交叉反应。