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181.
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Li Tang Yu Zhang Hong Pan Qiong Luo Xiao-Ming Zhu Min-Yue Dong Peter CK Leung Jian-Zhong Sheng He-Feng Huang 《Reproductive biology and endocrinology : RB&E》2009,7(1):144-8
Background
Progesterone plays an important role in the proliferation and differentiation of human endometrial cells (hECs). Large-dose treatment with progesterone has been used for treatment of endometrial proliferative disorders. However, the mechanisms behind remain unknown. 相似文献183.
Dong Wook Park Kyung-Chul Choi Colin D MacCalman Peter CK Leung 《Reproductive biology and endocrinology : RB&E》2009,7(1):81
Endometrial carcinoma is the most common neoplasm of the female genital tract, accounting for nearly one half of all gynecologic
cancers in the Western world. Although intensive research on pathological phenomena of endometrial cancer is currently going
on, but exact cause and biological aspects of this disease are not well described yet. In addition to well-documented roles
of gonadotropin-releasing hormone (GnRH) in hypopituitary ovarian (HPO) axis, the agonistic or antagonistic analogs (or both)
of GnRH have been shown to inhibit the proliferation of a variety of human gynecologic cancers. Thus, in the present study,
we further examined the possibility that GnRH induces integrin beta3 and activation of focal adhesion kinase (FAK) through
mitogen-activated protein kinases (MAPKs), ERK1/2 and p38, to inhibit the growth of HEC1A endometrial cancer cell line. As
a result, both GnRH-I and GnRH-II resulted in a significant increase in integrin beta3 expression and evoked the activation
of FAK in a time-dependent manner in these cells. In addition, these analogs induced an activation of ERK1/2 and p38 MAPK
in a time-dependent manner as downstream pathways of FAK. It appears that GnRH-II has much greater effect on the activation
of FAK, ERK1/2 and p38 compared to GnRH-I in these cells. Further, we demonstrated that the growth inhibition of HEC1A cells
by GnRH-I or GnRH-II is involved in the activation of integrin-FAK and ERK1/2 and p38 MAPK pathways. Taken together, these
results suggest that GnRH may be involved in the inhibition of endometrial cancer cell growth via activation of integrin beta3
and FAK as a direct effect. This knowledge could contribute to a better understanding of the mechanisms implicated in the
therapeutic action of GnRH and its biomedical application for the treatment against endometrial cancer. 相似文献
184.
Victor?TS?Chen Chun?Peng Peter?CK?LeungEmail author 《Reproductive biology and endocrinology : RB&E》2003,1(1):29
Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state level of activin type I receptor (ActRI) mRNA in immortalized extravillous trophoblasts (IEVT) cells was measured using competitive PCR (cPCR). An internal standard of ActRI cDNA for cPCR was constructed for the quantification of ActRI mRNA levels in IEVT cells. ActRI mRNA levels were increased in a dose-dependent manner by activin-A with the maximal effect observed at the dose of 10 ng/ml. Time course studies revealed that activin-A had maximal effects on ActRI mRNA levels at 6 hours after treatment. The effects of activin-A on ActRI mRNA levels was blocked by follistatin, an activin binding protein, in a dose-dependent manner. In addition, inhibin-A inhibited basal, as well as activin-A-induced ActRI mRNA levels. These findings provide evidence, for the first time, that activin-A modulates ActRI mRNA levels in human trophoblast cells. 相似文献
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Callahan R Labunskiy DA Logvinova A Abdallah M Liu C Cotten JF Yost CS 《Biochemical and biophysical research communications》2004,319(2):525-530
Tandem pore domain (2P) K channels constitute the most diverse family of K channels and are responsible for background (leak or baseline) K currents. Of the 15 human 2P K channels, TASK-1, TASK-2, and TASK-3 are uniquely sensitive to physiologic pH changes as well as being inhibited by local anesthetics and activated by volatile anesthetics. In this study polyclonal antibodies selective for TASK-3 have been used to localize its expression in the rat central nervous system (CNS). TASK-3 immunostaining was found in rat cortex, hypothalamus, and hippocampus. Double immunofluorescent studies identified a discrete population of TASK-3 expressing neurons scattered throughout cortex. Using immunogold electron microscopy TASK-3 was identified at the cell surface associated with synapses and within the intracellular synthetic compartments. These results provide a more finely detailed picture of TASK-3 expression and indicate a role for TASK-3 in modulating cerebral synaptic transmission and responses to CNS active drugs. 相似文献
187.
Young HE Duplaa C Romero-Ramos M Chesselet MF Vourc'h P Yost MJ Ericson K Terracio L Asahara T Masuda H Tamura-Ninomiya S Detmer K Bray RA Steele TA Hixson D el-Kalay M Tobin BW Russ RD Horst MN Floyd JA Henson NL Hawkins KC Groom J Parikh A Blake L Bland LJ Thompson AJ Kirincich A Moreau C Hudson J Bowyer FP Lin TJ Black AC 《Cell biochemistry and biophysics》2004,40(1):1-80
Tissue restoration is the process whereby multiple damaged cell types are replaced to restore the histoarchitecture and function
to the tissue. Several theories, have been proposed to explain the phenomenon of tissue restoration in amphibians and in animals
belonging to higher order. These theories include dedifferentiation of damaged tissues, transdifferentiation of lineage-committed
progenitor cells, and activation of reserve, precursor cells. Studies by Young et al. and others demonstrated that connective
tissue compartments throughout postnatal individuals contain reserve precursor cells. Subsequent repetitive single cell-cloning
and cell-sorting studies revealed that these reserve precursor cells consisted of multiple populations of cells, including,
tissue-specific progenitor cells, germ-layer lineage stem cells, and pluripotent stem cells. Tissue-specific progenitor cells
display various capacities for differentiation, ranging from unipotency (forming a single cell type) to multipotency (forming
multiple cell types). However, all progenitor cells demonstrate a finite life span of 50 to 70 population doublings before
programmed cell senescence and cell death occurs. Germ-layer lineage stem cells can form a wider range of cell types than
a progenitor cell. An individual germ-layer lineage stem cell can form all cells types within its respective germ-layer lineage
(i.e., ectoderm, mesoderm, or endoderm). Pluripotent stem cells can form a wider range of cell types than a single germ-layer
lineage stem cell. A single pluripotent stem cell can form cells belonging to all three germ layer lineages. Both germ-layer
lineage stem cells and pluripotent stem cells exhibit extended capabilities for self-renewal, far surpassing the limited life
span of progenitor cells (50–70 population doublings). The authors propose that the activation of quiescent tissue-specific
progenitor cells, germ-layer lineage stem cells, and/or pluripotent stem cells may be a potential explanation, along with
dedifferentiation and transdifferentiation, for the process of tissue restoration. Several model systems are currently being
investigated to determine the possibilities of using these adult quiescent reserve precursor cells for tissue engineering. 相似文献
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