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571.
Yoshitsugu Osumi Shunzo Aibara Koichiro Sakae Motohatsu Fujiwara 《Life sciences》1977,20(8):1407-1416
To investigate the role of central noradrenaline (NA) in gastric functions, changes in mucosal blood flow (MBF) and acid secretion following electrical stimulation of the lateral hypothalamic area (LHA) and the effects of NA on these parameters were examined in rats anesthetized with urethane. NA 10 μg/animal injected into the lateral ventricle decreased the basal value of both the gastric MBF and acid output, while the same dose of acetycholine or dopamine was without effect. Repetitive electrical stimulation of LHA at 10 cycles/sec, 0.5 mA, 2 msec for 10 min elicited a significant, reproducible increase in both gastric MBF and acid output. NA 10 μg/animal injected into the lateral ventricle completely blocked these increases induced by the electrical stimulation. These data suggest that a central noradrenergic inhibitory mechanism is involved in regulation of the gastric MBF and acid secretion. 相似文献
572.
Kenji Ogawa Takao Katsube Masanori Hirai Hirokazu Yagawa Tetsuro Kajiwara Motoo Saito Seiji Hashimoto Takeshi Yoshida 《Biotherapy》1993,7(1):39-45
Twenty two surgical specimens of gastric cancer resected after administration of OK-432 for the skin reaction test were examined to determine whether the cancer cells had the same antigens as OK-432, a product of hemolytic streptococcus cells. When the tissues were stained by the PAP method with anti-Su streptococcus antibody used as the primary antibodies, the common antigens were demonstrated in 10 (45.5%) of the 22. The presence or absence of the common antigens was independent of the degree of skin reaction to OK-432, and the relations of the common antigens to other host responses were not clear in this study. This is the first report for the presence of such common antigens between human gastric cancer and OK-432.Abbreviations PAP
peroxidase anti-peroxidase
- anti-Su
anti-Su Streptococcus, Su-strain
- TIL
tumor infiltration of lymphocytes 相似文献
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