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81.
82.
Hayashizaki Y 《Comptes rendus biologies》2003,326(10-11):923-929
The Riken mouse genome encyclopedia a comprehensive full-length cDNA collection and sequence database. High-level functional annotation is based on sequence homology search, expression profiling, mapping and protein-protein interactions. More than 1000000 clones prepared from 163 tissues were end-sequenced and classified into 128000 clusters, and 60000 representative clones were fully sequenced representing 24000 clear protein-encoding genes. The application of the mouse genome database for positional cloning and gene network regulation analysis is reported. 相似文献
83.
Yamashita T Deguchi K Sehara Y Lukic-Panin V Zhang H Kamiya T Abe K 《Neurochemical research》2009,34(4):707-710
Possible strategies for treating ischemic stroke include: (1) Neuroprotection: preventing damaged neurons from undergoing
apoptosis in the acute phase of cerebral ischemia; (2) Stem cell therapy: the repair of broken neuronal networks with newly
born neurons in the chronic phase of cerebral ischemia. Firstly, we studied the neuroprotective effect of a calcium channel
blocker, azelnidipine, or a by-product of heme degradation, biliverdin, in the ischemic brain. These results revealed both
azelnidipine and biliverdin had a neuroprotective effect in the ischemic brain through their anti-oxidative property. Secondly,
we investigated the role of granulocyte colony-stimulating factor (G-CSF) by administering G-CSF to rats after cerebral ischemia
and found G-CSF plays a critical role in neuroprotection. Lastly, we developed a restorative stroke therapy with a bio-affinitive
scaffold, which is able to provide an appropriate environment for newly born neurons. In the future, we will combine these
strategies to develop more effective therapies for treatment of strokes.
Special issue article in honor of Dr. Akitane Mori. 相似文献
84.
85.
Hajjaj H.M. Abdu-Allah Kozo Watanabe Koji Hayashizaki Chiaki Takaku Taichi Tamanaka Hiromu Takematsu Yasunori Kozutsumi Takeshi Tsubata Hideharu Ishida Makoto Kiso 《Bioorganic & medicinal chemistry letters》2009,19(19):5573-5575
Our previous study revealed that compound 1 (9-(4′-hydroxy-4-biphenyl)acetamido-9-deoxy-Neu5Gcα2-6GalOMP) has the most promising affinity for mCD22. Replacing the subterminal galactose residue of 1 with benzyl or biphenylmethyl as aglycone led to 38- and 20-fold higher potency, respectively. This discovery represents a new direction in inhibitor design suitable for pharmaceutical development. 相似文献
86.
Matheus Carvalho De Carvalho Ken‐Ichi Hayashizaki Hisao Ogawa 《Journal of phycology》2009,45(3):761-770
Progress in the study of stable isotope discrimination in carbon assimilation by aquatic macrophytes has been slower than for other groups of primary producers, such as phytoplankton and terrestrial plants. A probable reason has been the methodologies employed for such a study: field collections or long‐term incubations, both relying on the observation of changes in carbon isotope composition of plant tissue. Here, we present a short‐term incubation method based on the change in carbon stable isotope composition in water. Its fundamental advantage over the other approaches is that the change in stable isotope composition in water in a closed system is much faster than in the plant tissue. We applied the method to investigate the relationship between carbon assimilation intensity and isotope discrimination. The results included a relatively small discrimination in respiration, a significant influence of carbon assimilation rate on discrimination, and the suggestion of HCO3? or CO2 uptake in photosynthesis. The information gathered using this method would be difficult to obtain in other ways, and so we believe that it should contribute to a better understanding of the physiology and ecology of aquatic macrophytes. 相似文献
87.
Atsutaka Kubosaki Yasuhiro Tomaru Michihira Tagami Erik Arner Hisashi Miura Takahiro Suzuki Masanori Suzuki Harukazu Suzuki Yoshihide Hayashizaki 《Genome biology》2009,10(4):R41-14
Background
Immediate early genes are considered to play important roles in dynamic gene regulatory networks following exposure to appropriate stimuli. One of the immediate early genes, early growth response gene 1 (EGR-1), has been implicated in differentiation of human monoblastoma cells along the monocytic commitment following treatment with phorbol ester. EGR-1 has been thought to work as a modifier of monopoiesis, but the precise function of EGR-1 in monocytic differentiation has not been fully elucidated. 相似文献88.
89.
Hattori Y Asano T Niki Y Kondoh H Kirihata M Yamaguchi Y Wakamiya T 《Bioorganic & medicinal chemistry》2006,14(10):3258-3262
Magnetic resonance imaging (MRI) and boron-neutron capture therapy (BNCT) are quite attractive techniques for diagnosis and treatment of cancer, respectively. In order to progress the study on both MRI and BNCT, the novel compounds containing 19F and 10B atoms in a single molecule were designed and synthesized. In the present paper, the syntheses and the internalization rates into tumor cells of these compounds are elucidated. 相似文献
90.
Yoshikawa F Banno Y Otani Y Yamaguchi Y Nagakura-Takagi Y Morita N Sato Y Saruta C Nishibe H Sadakata T Shinoda Y Hayashi K Mishima Y Baba H Furuichi T 《PloS one》2010,5(11):e13932