全文获取类型
收费全文 | 466篇 |
免费 | 39篇 |
国内免费 | 79篇 |
专业分类
584篇 |
出版年
2024年 | 2篇 |
2023年 | 8篇 |
2022年 | 19篇 |
2021年 | 33篇 |
2020年 | 17篇 |
2019年 | 28篇 |
2018年 | 22篇 |
2017年 | 15篇 |
2016年 | 16篇 |
2015年 | 34篇 |
2014年 | 55篇 |
2013年 | 47篇 |
2012年 | 51篇 |
2011年 | 34篇 |
2010年 | 24篇 |
2009年 | 30篇 |
2008年 | 33篇 |
2007年 | 21篇 |
2006年 | 13篇 |
2005年 | 12篇 |
2004年 | 9篇 |
2003年 | 9篇 |
2002年 | 5篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 1篇 |
排序方式: 共有584条查询结果,搜索用时 0 毫秒
91.
The effects of long-term alcohol consumption on the mitogen-activated protein kinases (MAPKs) pathway and N-methyl-D-aspartate-type glutamate receptor 1 (GluN1) subunits in the mesocorticolimbic system remain unclear. In the present study, rats were allowed to consume 6% (v/v) alcohol solution for 28 consecutive days. Locomotor activity and behavioral signs of withdrawal were observed. Phosphorylation and expression of extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), p38 protein kinase and GluN1 in the nucleus accumbens, caudate putamen, amygdala, hippocampus and prefrontal cortex of these rats were also measured. Phosphorylation of ERK, but not JNK or p38, was decreased in all five brain regions studied in alcohol-drinking rats. The ratio of phospho/total-GluN1 subunit was reduced in all five brain regions studied. Those results suggest that the long-term alcohol consumption can inhibits GluN1 and ERK phosphorylation, but not JNK or p38 in the mesocorticolimbic system, and these changes may be relevant to alcohol dependence. To differentiate alcohol-induced changes in ERK and GluN1 between acute and chronic alcohol exposure, we have determined levels of phospho-ERK, phospho-GluN1 and total levels of GluN1 after acute alcohol exposure. Our data show that 30 min following a 2.5 g/kg dose of alcohol (administered intragastrically), levels of phospho-ERK are decreased while those of phospho-GluN1 are elevated with no change in total GluN1 levels. At 24 h following the single alcohol dose, levels of phospho-ERK are elevated in several brain regions while there are no differences between controls and alcohol treated animals in phospho-GluN1 or total GluN1. Those results suggest that alcohol may differentially regulate GluN1 function and ERK activation depending on alcohol dose and exposure time in the central nervous system. 相似文献
92.
93.
Gong W Jiang Z Sun P Li L Jin Y Shao L Zhang W Liu B Zhang H Tang H Chen Y Yi Y Zhang D 《化学与生物多样性》2011,8(10):1833-1852
A series of 46 compounds derived from esculentoside A and its aglycone were synthesized and characterized. The effect of these compounds on lipopolysaccharide (LPS)-induced NO production, haemolytic activity, and cell viability was evaluated. Structure-activity relationship was established by comparing the derivatives of esculentoside A with its aglycone derivatives. Both the aglycone and its derivatives showed higher inhibitory effects on LPS-induced NO production, and lower haemolytic activities than esculentoside A and its derivatives. 相似文献
94.
95.
Huang Y Yang Y Gao R Yang X Yan X Wang C Jiang S Yu L 《Biochemical and biophysical research communications》2011,(1):181-185
TGF-β (transforming growth factor-β), a pleiotropic cytokine that regulates diverse cellular processes, has been suggested to play critical roles in cell proliferation, migration, and carcinogenesis. Here we found a novel E3 ubiquitin ligase RLIM which can directly bind to Smurf2, enhancing TGF-β responsiveness in osteosarcoma U2OS cells. We constructed a U2OS cell line stably over-expressing RLIM and demonstrated that RLIM promoted TGF-β-driven migration of U2OS cells as tested by wound healing assay. Our results indicated that RLIM is an important positive regulator in TGF-β signaling pathway and cell migration. 相似文献
96.
Zeyu Zhang Huihui Wang Yongsheng Wang Feihu Xi Huiyuan Wang Markus V. Kohnen Pengfei Gao Wentao Wei Kai Chen Xuqing Liu Yubang Gao Ximei Han Kaiqiang Hu Hangxiao Zhang Qiang Zhu Yushan Zheng Bo Liu Ayaz Ahmad Yau-Heiu Hsu Steven E. Jacobsen Lianfeng Gu 《The Plant journal : for cell and molecular biology》2021,106(2):435-453
97.
98.
99.
Guo Z Chen Y Huang CQ Gross TD Pontillo J Rowbottom MW Saunders J Struthers S Tucci FC Xie Q Wade W Zhu YF Wu D Chen C 《Bioorganic & medicinal chemistry letters》2005,15(10):2519-2522
Uracil derivatives were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor. Optimization at the 1- and 5-positions of the uracil resulted in potent compounds such as 24 (Ki=0.45 nM). 相似文献
100.