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301.
The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in most human carcinomas. The cytoplasmic domain of MUC1 interacts with glycogen synthase kinase 3 beta (GSK3 beta) and thereby decreases binding of MUC1 and beta-catenin. The present studies demonstrate that MUC1 associates with the c-Src tyrosine kinase. c-Src phosphorylates the MUC1 cytoplasmic domain at a YEKV motif located between sites involved in interactions with GSK3 beta and beta-catenin. The results demonstrate that the c-Src SH2 domain binds directly to pYEKV and inhibits the interaction between MUC1 and GSK3 beta. Moreover and in contrast to GSK3 beta, in vitro and in vivo studies demonstrate that c-Src-mediated phosphorylation of MUC1 increases binding of MUC1 and beta-catenin. The findings support a novel role for c-Src in regulating interactions of MUC1 with GSK3 beta and beta-catenin. 相似文献
302.
Doris Albinsky Yuji Sawada Ayuko Kuwahara Mutsumi Nagano Akiko Hirai Kazuki Saito Masami Yokota Hirai 《Amino acids》2010,39(4):1067-1075
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Masamitsu Mikami Tatsuya Masuda Takuya Kanatani Mina Noura Katsutsugu Umeda Hidefumi Hiramatsu Hirohito Kubota Tomoo Daifu Atsushi Iwai Etsuko Yamamoto Hattori Kana Furuichi Saho Takasaki Sunao Tanaka Yasuzumi Matsui Hidemasa Matsuo Masahiro Hirata Tatsuki R. Kataoka Tatsutoshi Nakahata Yasumichi Kuwahara Tomoko Iehara Hajime Hosoi Yoichi Imai Junko Takita Hiroshi Sugiyama Souichi Adachi Yasuhiko Kamikubo 《Molecules and cells》2022,45(12):886
306.
Toshihiko Kakiuchi Muneaki Matsuo Hiroyoshi Endo Yasuhisa Sakata Motohiro Esaki Takahiro Noda Ichiro Imamura Kazutoshi Hashiguchi Shinichi Ogata Yasuhiko Fujioka Keiichiro Hanada Kayoko Fukuda Masaya Yoshimura Tetsuro Kajiwara Kentaroh Yamamoto Daisuke Yamaguchi Hiroharu Kawakubo Taro Akashi Michihiro Sumino Keiji Matsunaga Eriko Muro Atsuo Kuwahara Kazuto Taniguchi Koji Fukuyama Akira Watanabe Ayako Takamori Masumi Okuda Kohei Yamanouchi Kazuma Fujimoto 《Helicobacter》2021,26(2):e12776
307.
Motoki Endo Yosuke Inoue Keisuke Kuwahara Chihiro Nishiura Ai Hori Takayuki Ogasawara Miwa Yamaguchi Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Teppei Imai Akiko Nishihara Toshiaki Miyamoto Naoko Sasaki Akihiko Uehara Makoto Yamamoto Taizo Murakami Makiko Shimizu Masafumi Eguchi Takeshi Kochi Satsue Nagahama Kentaro Tomita Naoki Kunugita Takeshi Tanigawa Maki Konishi Akiko Nanri Isamu Kabe Tetsuya Mizoue Seitaro Dohi 《Obesity (Silver Spring, Md.)》2020,28(2):437-444
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In the present paper, we discuss the evolution of an upper Permian anagenetic lineage of polycystine radiolarians belonging to the genus Albaillella. This genus is characterized by increasing curvature of the shell during the upper Permian and the trend is reversed (proteromorphic retrogradation) in the Lower Triassic with the sudden appearance of forms that are homeomorphic to the earliest Permian representative of the genus. These primitive-looking forms are derived from their immediate ancestors by retrograde evolution, a phenomenon which has been described as proteromorphosis. 相似文献
310.
M. Kuroid M. Kuwahara Y. Tsuruta M. Murakami Y. Matsuoka 《Preparative biochemistry & biotechnology》2013,43(3):333-349
ABSTRACT Two molecular species of nonspecific cross-reacting antigens, NCA-90 and NCA-50 with mol. wts. of 90,000 and 50,000, respectively, wereeffectively extracted with phosphatidylinositol-specific phospholipase C (PI-PLC) from human lung tissues, followed by extraction with perchloric acid, immunoaffinity chromatography with anti-NCA adsorbent, and gel filtration on a TSK G3000SW column. The yields of NCA were about 2 times more than those obtained by the usual method without PI-PLC. Addition of 0.05 unit of PI-PLC to 1 g of lung tissue and incubation at 37°C for 1 h with continuous shaking seem to be practically sufficient for NCA extraction. The immunochemical properties of the NCAs thus obtained were found to be identical to those of NCAs obtained by the ordinary method. 相似文献