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排序方式: 共有207条查询结果,搜索用时 15 毫秒
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Jiajie Wei Rigel J. Kishton Matthew Angel Crystal S. Conn Nicole Dalla-Venezia Virginie Marcel Anne Vincent Frédéric Catez Sabrina Ferré Lilia Ayadi Virginie Marchand Devin Dersh James S. Gibbs Ivaylo P. Ivanov Nathan Fridlyand Yohann Couté Jean-Jacques Diaz Shu-Bing Qian Jonathan W. Yewdell 《Molecular cell》2019,73(6):1162-1173.e5
93.
Frédéric Blanc Vincent Noblet Nathalie Philippi Benjamin Cretin Jack Foucher Jean-Paul Armspach Fran?ois Rousseau the Alzheimer's Disease Neuroimaging Initiative 《PloS one》2014,9(12)
Objectives
We investigated the neural basis of hallucinations Alzheimer''s disease (AD) by applying voxel-based morphometry (VBM) to anatomical and functional data from the AD Neuroimaging Initiative.Methods
AD patients with hallucinations, based on the Neuropsychiatric Inventory (NPI-Q) (AD-hallu group; n = 39), were compared to AD patients without hallucinations matched for age, sex, educational level, handedness and MMSE (AD-c group; n = 39). Focal brain volume on MRI was analyzed and compared between the two groups according to the VBM method. We also performed voxel-level correlations between brain volume and hallucinations intensity. A similar paradigm was used for the PET analysis. “Core regions” (i.e. regions identified in both MRI and PET analyses, simply done by retaining the clusters obtained from the two analyses that are overlapping) were then determined.Results
Regions with relative atrophy in association with hallucinations were: anterior part of the right insula, left superior frontal gyrus and lingual gyri. Regions with relative hypometabolism in association with hallucinations were a large right ventral and dorsolateral prefrontal area. "Core region" in association with hallucinations was the right anterior part of the insula. Correlations between intensity of hallucinations and brain volume were found in the right anterior insula, precentral gyrus, superior temporal gyrus, and left precuneus. Correlations between intensity of hallucinations and brain hypometabolism were found in the left midcingulate gyrus. We checked the neuropathological status and we found that the 4 patients autopsied in the AD-hallu group had the mixed pathology AD and Dementia with Lewy bodies (DLB).Conclusion
Neural basis of hallucinations in cognitive neurodegenerative diseases (AD or AD and DLB) include a right predominant anterior-posterior network, and the anterior insula as the core region. This study is coherent with the top-down/bottom-up hypotheses on hallucinations but also hypotheses of the key involvement of the anterior insula in hallucinations in cognitive neurodegenerative diseases. 相似文献94.
Philippe Lemay Susan P. Knowler Samir Bouasker Yohann Nédélec Simon Platt Courtenay Freeman Georgina Child Luis B. Barreiro Guy A. Rouleau Clare Rusbridge Zoha Kibar 《PloS one》2014,9(4)
Chiari-like malformation (CM) is a developmental abnormality of the craniocervical junction that is common in the Griffon Bruxellois (GB) breed with an estimated prevalence of 65%. This disease is characterized by overcrowding of the neural parenchyma at the craniocervical junction and disturbance of cerebrospinal fluid (CSF) flow. The most common clinical sign is pain either as a direct consequence of CM or neuropathic pain as a consequence of secondary syringomyelia. The etiology of CM remains unknown but genetic factors play an important role. To investigate the genetic complexity of the disease, a quantitative trait locus (QTL) approach was adopted. A total of 14 quantitative skull and atlas measurements were taken and were tested for association to CM. Six traits were found to be associated to CM and were subjected to a whole-genome association study using the Illumina canine high density bead chip in 74 GB dogs (50 affected and 24 controls). Linear and mixed regression analyses identified associated single nucleotide polymorphisms (SNPs) on 5 Canis Familiaris Autosomes (CFAs): CFA2, CFA9, CFA12, CFA14 and CFA24. A reconstructed haplotype of 0.53 Mb on CFA2 strongly associated to the height of the cranial fossa (diameter F) and an haplotype of 2.5 Mb on CFA14 associated to both the height of the rostral part of the caudal cranial fossa (AE) and the height of the brain (FG) were significantly associated to CM after 10 000 permutations strengthening their candidacy for this disease (P = 0.0421, P = 0.0094 respectively). The CFA2 QTL harbours the Sall-1 gene which is an excellent candidate since its orthologue in humans is mutated in Townes-Brocks syndrome which has previously been associated to Chiari malformation I. Our study demonstrates the implication of multiple traits in the etiology of CM and has successfully identified two new QTL associated to CM and a potential candidate gene. 相似文献
95.
Alexis Forterre Audrey Jalabert Emmanuelle Berger Mathieu Baudet Karim Chikh Elisabeth Errazuriz Joffrey De Larichaudy Stéphanie Chanon Michèle Weiss-Gayet Anne-Marie Hesse Michel Record Alain Geloen Etienne Lefai Hubert Vidal Yohann Couté Sophie Rome 《PloS one》2014,9(1)
Exosomes are nanometer-sized microvesicles formed in multivesicular bodies (MVBs) during endosome maturation. Exosomes are released from cells into the microenvironment following fusion of MVBs with the plasma membrane. During the last decade, skeletal muscle-secreted proteins have been identified with important roles in intercellular communications. To investigate whether muscle-derived exosomes participate in this molecular dialog, we determined and compared the protein contents of the exosome-like vesicles (ELVs) released from C2C12 murine myoblasts during proliferation (ELV-MB), and after differentiation into myotubes (ELV-MT). Using a proteomic approach combined with electron microscopy, western-blot and bioinformatic analyses, we compared the protein repertoires within ELV-MB and ELV-MT. We found that these vesicles displayed the classical properties of exosomes isolated from other cell types containing components of the ESCRT machinery of the MVBs, as well as numerous tetraspanins. Specific muscle proteins were also identified confirming that ELV composition also reflects their muscle origin. Furthermore quantitative analysis revealed stage-preferred expression of 31 and 78 proteins in ELV-MB and ELV-MT respectively. We found that myotube-secreted ELVs, but not ELV-MB, reduced myoblast proliferation and induced differentiation, through, respectively, the down-regulation of Cyclin D1 and the up-regulation of myogenin. We also present evidence that proteins from ELV-MT can be incorporated into myoblasts by using the GFP protein as cargo within ELV-MT. Taken together, our data provide a useful database of proteins from C2C12-released ELVs throughout myogenesis and reveals the importance of exosome-like vesicles in skeletal muscle biology. 相似文献
96.
An analytical parametric model was developed to estimate the natural biological variations in muscle forces and their effect on the hip forces subject only to physiological constraints and not predefined optimization criterion. Force predictions are based on the joint kinematics and kinetics of each subject, a previously published muscle model, and physiological constraints on the muscle force distributions. The model was used to determine the hip contact forces throughout the stance phase of gait of a subject with a total hip replacement (THR). The parametrically modeled peak hip force without antagonistic muscle activity varied from 2.7 to 3.2 Body Weights (mean 2.9 Body Weights), which agreed well with published in vivo measurements from instrumented THRs in other subjects. For every 10% increase in antagonistic activity, the mean peak hip force increased by 0.2 Body Weights. The parametric model allows one to examine the effect of specific muscle weaknesses or increased antagonistic muscle activity on the hip forces. The model also provides a tool for studying the effect of gait adaptations on hip forces, as predictions are based on each individual's gait data. Differences in peak forces between subjects can then be evaluated relative to the uncertainty in not knowing the precise muscle force distributions. 相似文献
97.
Vic Norris Abdallah Zemirline Patrick Amar Jean Nicolas Audinot Pascal Ballet Eshel Ben-Jacob Gilles Bernot Guillaume Beslon Armelle Cabin Eric Fanchon Jean-Louis Giavitto Nicolas Glade Patrick Greussay Yohann Grondin James A. Foster Guillaume Hutzler Jürgen Jost Francois Kepes Olivier Michel Franck Molina Jacqueline Signorini Pasquale Stano Alain R. Thierry 《Theorie in den Biowissenschaften》2011,130(3):211-228
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99.
100.
L. Hamama A. Naouar R. Gala L. Voisine S. Pierre J. Jeauffre D. Cesbron F. Leplat F. Foucher N. Dorion L. Hibrand-Saint Oyant 《Plant cell reports》2012,31(11):2015-2029