Jie Yang  Chuan Liu  Zhang Jihang  Jie Yu  Limeng Dai  Xiaohan Ding  Youzhu Qiu  Sanjiu Yu  Yuanqi Yang  Yuzhang Wu  Lan Huang 《Molecular Genetics & Genomic Medicine》2019,7(10)

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Hongyu Deng  Ming Chen  Xinwu Guo  Jianfu Heng  Xunxun Xu  Limin Peng  Hui Jiang  Guoli Li  Julia X. Day  Jinliang Li  Dongyong Shan  Yinghua Li  Yanjie Zhou  Bin Liu  Lizhong Dai  Xiaochun Wang  Jun Wang 《Molecular Genetics & Genomic Medicine》2019,7(6)

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Qiang Yu  Weiqi Dai  Jie Ji  Liwei Wu  Jiao Feng  Jingjing Li  Yuanyuan Zheng  Yan Li  Ziqi Cheng  Jie Zhang  Jianye Wu  Xuanfu Xu  Chuanyong Guo 《Journal of cellular and molecular medicine》2022,26(10):3031

Aerobic glycolysis is a well‐known hallmark of hepatocellular carcinoma (HCC). Hence, targeting the key enzymes of this pathway is considered a novel approach to HCC treatment. The effects of sodium butyrate (NaBu), a sodium salt of the short‐chain fatty acid butyrate, on aerobic glycolysis in HCC cells and the underlying mechanism are unknown. In the present study, data obtained from cell lines with mouse xenograft model revealed that NaBu inhibited aerobic glycolysis in the HCC cells in vivo and in vitro. NaBu induced apoptosis while inhibiting the proliferation of the HCC cells in vivo and in vitro. Furthermore, the compound inhibited the release of lactate and glucose consumption in the HCC cells in vitro and inhibited the production of lactate in vivo. The modulatory effects of NaBu on glycolysis, proliferation and apoptosis were related to its modulation of hexokinase 2 (HK2). NaBu downregulated HK2 expression via c‐myc signalling. The upregulation of glycolysis in the HCC cells induced by sorafenib was impeded by NaBu, thereby enhancing the anti‐HCC effect of sorafenib in vitro and in vivo. Thus, NaBu inhibits the expression of HK2 to downregulate aerobic glycolysis and the proliferation of HCC cells and induces their apoptosis via the c‐myc pathway.  相似文献   

    

Adeel ur Rehman  Per Olof Olsson  Aleena Akhtar  Arshad Ahmed Padhiar  Hanyang Liu  Yi Dai  Yu Gong  Yan Zhou  Naveed Khan  Haojun Yang  Liming Tang 《Journal of cellular and molecular medicine》2022,26(12):3329

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Qian Hu  Qi Wu  Binghong Dai  Jingwei Cui  Anam Khalid  Yang Li  Zaigui Wang 《Journal of applied microbiology》2022,132(5):3640-3649

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Ge Gao  Xue Hu  Yiwu Zhou  Juhong Rao  Xiaoyu Zhang  Yun Peng  Jiaxuan Zhao  Yanfeng Yao  Kunpeng Liu  Mengying Liang  Hang Liu  Fei Deng  Han Xia  Chao Shan  Zhiming Yuan 《中国病毒学》2022,37(2):299-302

Highlights
1. Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
2. The Delta variant grows faster than the early strain isolated from Wuhan in late 2019.
3. The shedding pattern, viral load and disease severity of Delta variant are similar with the early strain isolated from Wuhan in late 2019.
4. This study supports the attributed rapid disease spread of the Delta variant.  相似文献   

    

Ting Xue  Wei-Qin Du  Wen-Juan Dai  Yi-Shan Li  Shu-Feng Wang  Jun-Ling Wang  Xin-Ri Zhang 《Polish journal of microbiology》2022,71(1):27

Pneumocystis jirovecii is an opportunistic fungus that can cause severe and potentially fatal Pneumocystis pneumonia (PCP) in immunodeficient patients. In this study, we investigated the genetic polymorphisms of P. jirovecii at eight different loci, including six nuclear genes (ITS, 26S rRNA, sod, dhps, dhfr and β-Tub) and two mitochondrial genes (mtLSU-rRNA and cyb) in three PCP cases, including two patients with HIV infection and one without HIV infection in Shanxi Province, P.R. China. The gene targets were amplified by PCR followed by sequencing of plasmid clones. The HIV-negative patient showed a coinfection with two genotypes of P. jirovecii at six of the eight loci sequenced. Of the two HIV-positive patients, one showed a coinfection with two genotypes of P. jirovecii at the same two of the six loci as in the HIV-negative patient, while the other showed a single infection at all eight loci sequenced. None of the three drug target genes (dhfr, dhps and cyb) showed mutations known to be potentially associated with drug resistance. This is the first report of genetic polymorphisms of P. jirovecii in PCP patients in Shanxi Province, China. Our findings expand our understanding of the genetic diversity of P. jirovecii in China. Open in a separate window  相似文献   

    

Shanshan Qi  Susan Rutherford  Furong He  Bi-Cheng Dong  Bin Zhu  Zhicong Dai  Weiguo Fu  Hanping Mao  Daolin Du 《Journal of Plant Ecology》2022,15(3):650

植物生长调节剂通过克隆整合对空心莲子草顶端和基部生长的不同作用入侵植物不仅对全球生物多样性造成了巨大的威胁,同时也严重影响了农业生产与粮食安全。克隆整合使得相连植株进行资源共享,能促进入侵植物的生长从而获得优势。然而,入侵杂草 在植物调节剂(plant growth regulators, PGRs)影响下的克隆整合作用则很少有报道。PGRs被广泛应用于 农作物生产上,并能通过土壤淋溶、侵蚀和径流作用,影响分布在作物附近的农田杂草的生长。本 研究采用两种PGRs赤霉素(gibberellins, GA)和多效唑(paclobutrazol,PAC)处理恶性入侵杂草空心莲子草 (Alternanthera philoxeroides)基端,并保持或者通过剪切达到控制基端与顶端的连通,从而探究克隆整合作用在空心莲子草响应两种农业常用PGRs中的作用。研究结果表明,GA和PAC对空心莲子草生长的作用相反。GA通过克隆整合作用显著促进顶端植株的地上生长。相反地,PAC显著抑制基端和顶端的地 上生长,但是能够通过克隆整合作用显著促进基端和顶端的地下生长。这些研究结果解释了克隆整合作用能促进PGRs对空心莲子草生长的促进作用,这很可能是外来杂草能够成功入侵人为干扰较多的农业生态系统的重要原因之一。  相似文献   

    

Jian Li  Zhanrui Leng  Yueming Wu  Yizhou Du  Zhicong Dai  Asim Biswas  Xiaojun Zheng  Guanlin Li  Esawy Kasem Mahmoud  Hui Jia  Daolin Du 《Journal of Plant Ecology》2022,15(3):429

入侵植物与重金属胁迫的相互作用研究进展全球变化改变了植物群落的分布格局,包括入侵植物,而人为污染可能降低本地植物对入侵植物的抗性。因此,本文总结了近几十年本地植物、入侵植物和植物-土壤生态系统中重金属生物地球化学行为的研究,以加深我们对入侵植物与环境胁迫因子相互作用的认识。我们的研究结合已有文献报道表明：(i)入侵物种对环境胁迫的影响具有异质性, (ii)影响的大小是多变的, (iii)即使在同一影响类型内,影响类型也具有多向性。然而,入侵植物暴露在重金属环境中表现出更强的自我保护机制,对重金属的生物可利用性和毒性有正向或负向的影响。另一方面,由于入侵植物普遍具有较高的耐受性,加之本地植物暴露于有毒重金属污染时具有“逃逸行为”,重金属胁迫环境更有利于植物的成功入侵。但是,对于入侵植物的重金属等元素组成是否与污染地区的本地植物不同,目前尚无共识。因此,在全球范围内对外来入侵植物与本土植物的植物体内、凋落物和土壤污染物含量进行定量比较是今后研究的一个重要方向。  相似文献   

    

Jiangshuai Niu  Zhijiang Li  Jiarui Zhu  Rong Wu  Lingxin Kong  Tingli Niu  Xueying Li  Xinran Cheng  Jianying Li  Lingyan Dai 《Physiology and Molecular Biology of Plants》2022,28(9):1713

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