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31.
Mitigation of ammonia inhibition by internal dilution in high‐rate anaerobic digestion of food waste leachate and evidences of microbial community response
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Phenyl 2‐pyridyl ketoxime induces cellular senescence‐like alterations via nitric oxide production in human diploid fibroblasts
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Kyeong Eun Yang Hyun‐Jin Jang In‐Hu Hwang Young‐Ho Chung Jong‐Soon Choi Tae‐Hoon Lee Yun‐Jo Chung Min‐Seung Lee Mi Young Lee Eui‐Ju Yeo Ik‐Soon Jang 《Aging cell》2016,15(2):245-255
Phenyl‐2‐pyridyl ketoxime (PPKO) was found to be one of the small molecules enriched in the extracellular matrix of near‐senescent human diploid fibroblasts (HDFs). Treatment of young HDFs with PPKO reduced the viability of young HDFs in a dose‐ and time‐dependent manner and resulted in senescence‐associated β‐galactosidase (SA‐β‐gal) staining and G2/M cell cycle arrest. In addition, the levels of some senescence‐associated proteins, such as phosphorylated ERK1/2, caveolin‐1, p53, p16ink4a, and p21waf1, were elevated in PPKO‐treated cells. To monitor the effect of PPKO on cell stress responses, reactive oxygen species (ROS) production was examined by flow cytometry. After PPKO treatment, ROS levels transiently increased at 30 min but then returned to baseline at 60 min. The levels of some antioxidant enzymes, such as catalase, peroxiredoxin II and glutathione peroxidase I, were transiently induced by PPKO treatment. SOD II levels increased gradually, whereas the SOD I and III levels were biphasic during the experimental periods after PPKO treatment. Cellular senescence induced by PPKO was suppressed by chemical antioxidants, such as N‐acetylcysteine, 2,2,6,6‐tetramethylpiperidinyloxy, and L‐buthionine‐(S,R)‐sulfoximine. Furthermore, PPKO increased nitric oxide (NO) production via inducible NO synthase (iNOS) in HDFs. In the presence of NOS inhibitors, such as L‐NG‐nitroarginine methyl ester and L‐NG‐monomethylarginine, PPKO‐induced transient NO production and SA‐β‐gal staining were abrogated. Taken together, these results suggest that PPKO induces cellular senescence in association with transient ROS and NO production and the subsequent induction of senescence‐associated proteins . 相似文献
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H.T. Nguyen S. Kim N.H. Yu A.R. Park H. Yoon C.-H. Bae J.H. Yeo I.S. Kim J.-C. Kim 《Journal of applied microbiology》2019,126(3):894-904
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Vilizzi Lorenzo Copp Gordon H. Adamovich Boris Almeida David Chan Joleen Davison Phil I. Dembski Samuel Ekmekçi F. Güler Ferincz Árpád Forneck Sandra C. Hill Jeffrey E. Kim Jeong-Eun Koutsikos Nicholas Leuven Rob S. E. W. Luna Sergio A. Magalhães Filomena Marr Sean M. Mendoza Roberto Mourão Carlos F. Neal J. Wesley Onikura Norio Perdikaris Costas Piria Marina Poulet Nicolas Puntila Riikka Range Inês L. Simonović Predrag Ribeiro Filipe Tarkan Ali Serhan Troca Débora F. A. Vardakas Leonidas Verreycken Hugo Vintsek Lizaveta Weyl Olaf L. F. Yeo Darren C. J. Zeng Yiwen 《Reviews in Fish Biology and Fisheries》2019,29(3):529-568
Reviews in Fish Biology and Fisheries - The freshwater Fish Invasiveness Screening Kit (FISK) has been applied in 35 risk assessment areas in 45 countries across the six inhabited continents (11... 相似文献
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Cui Heqing Song Myoung Chong Lee Ji Young Yoon Yeo Joon 《Journal of industrial microbiology & biotechnology》2019,46(12):1707-1713
Journal of Industrial Microbiology & Biotechnology - Methylated flavonoids possess improved bioactivities compared to their unmethylated counterparts. In this study, for the efficient... 相似文献
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