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501.
Identification of 6 beta-hydroxydexamethasone as a major urinary metabolite of dexamethasone in man has been accomplished by nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry. Mass fragmentographic measurements revealed that more than 30% of the intravenously or orally administered dexamethasone dose was excreted in the 24-h urine as 6 beta-hydroxydexamethasone, while only a small fraction of the dose was excreted as unchanged dexamethasone and its glucuronic acid conjugate. 相似文献
502.
503.
Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF 总被引:1,自引:0,他引:1
Substituents on the nitrogen atom of the phosphorylcholine moiety of natural C16 platelet-activating factor (PAF) were modified or replaced by more bulky groups, and their hypotensive activities were examined with rats. As a result, it was found that N-methylpiperidine and N-methylpyrrolidine analogues were 3-10 times more potent than natural C16-PAF. 相似文献
504.
Isao Nagano Shiro Kasuya Nobuji Noda Teruo Yamashita 《Microbiology and immunology》1996,40(10):743-747
Four strains of Orientia tsutsugamushi (KN-1, KN-2, KN-3 and GJ-1) isolated from patients in an area of Gifu Prefecture, Japan, in which tsutsugamushi disease is newly endemic, were examined for their virulence in mice. Among these, KN-1 (identified as Kawasaki type), GJ-1 (identified as Kuroki type) and KN-2 strains were found to be non-lethal for BALB/c mice as well as CH3/HeJ mice, even with high doses (106 × being the 50% mouse infectious dose). On the other hand, the KN-3 strain was found to be sufficiently virulent to kill BALB/c mice. Among the prototype strains (Gilliam, Karp and Kato), the Karp and Kato strains exhibited high virulence to mice, while the Gilliam strain killed only a susceptible strain of mouse. BALB/c mice infected with KN-1 and KN-2 strains showed significant splenomegaly and moderate ascites accumulation in the first week of infection, while these symptoms became prominent during the second week of infection using KN-3, Karp and Kato strains. After infection with the GJ-1 strain, these symptoms were not observed. Antibody responses induced by infections with highly virulent strains were lower than that with low or intermediate virulent strains. 相似文献
505.