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991.
Kazuhiro Kitajima Yuko Suenaga Tomonori Kanda Daisuke Miyawaki Kenji Yoshida Yasuo Ejima Ryohei Sasaki Hirokazu Komatsu Miki Saito Naoki Otsuki Ken-ichi Nibu Naomi Kiyota Tsutomu Minamikawa Kazuro Sugimura 《PloS one》2014,9(5)
Background and Purpose
To investigate the prognostic value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with laryngeal cancer.Materials and Methods
The study included 51 patients of whom 30 underwent definitive radiotherapy with or without chemotherapy and 21 underwent radical surgery with or without adjuvant chemoradiation therapy. FDG uptake by both the primary lesion and the neck node was measured using the maximum standardized uptake value (SUVmax). The effects of clinicopathological factors including primary tumor SUVmax and nodal SUVmax on progression-free survival, local control, nodal progression-free survival, and distant metastasis-free survival were evaluated using the log-rank test and Cox method.Results
The median duration of follow-up was 48.6 months (range 8 to 82.1 months). Univariate analysis showed that nodal SUVmax, N status, and tumor TNM stage were significantly associated with recurrence, whereas primary tumor SUVmax, age, treatment strategy and T status were not. Multivariate analysis demonstrated that only the nodal SUVmax was a significantly unfavorable factor for progression-free survival (p = 0.029, hazard ratio 0.54, 95% CI 0.38-0.87) and nodal progression-free survival (p = 0.023, hazard ratio 0.51, 95% CI 0.34-0.81). ROC curve analysis and log-rank test showed that patients with a high nodal SUVmax (≧4) had a significantly lower progression-free survival rate than those with a low SUVmax (<4; p<0.0001).Conclusions
The pretreatment SUVmax of nodal disease in patients with laryngeal cancer is prognostic for recurrence. 相似文献992.
Ivan Babic Erik S. Anderson Kazuhiro Tanaka Deliang Guo Kenta Masui Bing Li Shaojun Zhu Yuchao Gu Genaro R. Villa David Akhavan David Nathanson Beatrice Gini Sergey Mareninov Rui Li Carolina Espindola Camacho Siavash K. Kurdistani Ascia Eskin Stanley F. Nelson Paul S. Mischel 《Cell metabolism》2013,17(6):1000-1008
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993.
994.
Chikao Hashimoto Kazuhiro Sugimoto Youhei Takahashi Mitsuo Kodomari 《Journal of peptide science》2013,19(10):659-662
In the synthesis of dipeptides (Boc‐AA1‐AA2‐OPac: AA1 and AA2 represent amino acids) protected by phenacyl (Pac) ester, amines and solid bases as the base for the conversion of the trifluoroacetic acid (TFA) salt of the amino component (TFA·H‐AA2‐OPac) into the corresponding free amino component (H‐AA2‐OPac) were examined. The synthesis of a dipeptide (Boc‐Ala‐Gly‐OPac) using amines for the conversion afforded an unsatisfactory yield with by‐products. On the other hand, the use of neutral alumina‐supported Na2CO3 (Na2CO3/n‐Al2O3) as a solid base for the conversion provided the dipeptide in a quantitative yield without by‐products. The application of Na2CO3/n‐Al2O3 to the synthesis of some dipeptides protected by Pac ester gave the desired peptides in excellent yields. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd. 相似文献
995.
996.
Itoh Kazuhiro Iwasaki Hiromichi Negoro Eiju Shigemi Hiroko Tokimatsu Issei Tsutani Hiroshi Yamauchi Takahiro 《Mycopathologia》2021,186(1):113-117
Mycopathologia - Invasive trichosporonosis is a rare and lethal fungal infection that occurs in immunocompromised patients. Breakthrough trichosporonosis can occur in patients treated with... 相似文献
997.
Kentaro Ide Sanai Takahashi Keiko Sakai Yuki Taga Tomonori Ueno David Dickens Rosalind Jenkins Francesco Falciani Takako Sasaki Kazuhiro Ooi Shuichi Kawashiri Kazunori Mizuno Shunji Hattori Takao Sakai 《The Journal of biological chemistry》2021,297(1)
Collagen-derived hydroxyproline (Hyp)-containing peptides have a variety of biological effects on cells. These bioactive collagen peptides are locally generated by the degradation of endogenous collagen in response to injury. However, no comprehensive study has yet explored the functional links between Hyp-containing peptides and cellular behavior. Here, we show that the dipeptide prolyl-4-hydroxyproline (Pro-Hyp) exhibits pronounced effects on mouse tendon cells. Pro-Hyp promotes differentiation/maturation of tendon cells with modulation of lineage-specific factors and induces significant chemotactic activity in vitro. In addition, Pro-Hyp has profound effects on cell proliferation, with significantly upregulated extracellular signal–regulated kinase phosphorylation and extracellular matrix production and increased type I collagen network organization. Using proteomics, we have predicted molecular transport, cellular assembly and organization, and cellular movement as potential linked-network pathways that could be altered in response to Pro-Hyp. Mechanistically, cells treated with Pro-Hyp demonstrate increased directional persistence and significantly increased directed motility and migration velocity. They are accompanied by elongated lamellipodial protrusions with increased levels of active β1-integrin–containing focal contacts, as well as reorganization of thicker peripheral F-actin fibrils. Pro-Hyp–mediated chemotactic activity is significantly reduced (p < 0.001) in cells treated with the mitogen-activated protein kinase kinase 1/2 inhibitor PD98059 or the α5β1-integrin antagonist ATN-161. Furthermore, ATN-161 significantly inhibits uptake of Pro-Hyp into adult tenocytes. Thus, our findings document the molecular basis of the functional benefits of the Pro-Hyp dipeptide in cellular behavior. These dynamic properties of collagen-derived Pro-Hyp dipeptide could lead the way to its application in translational medicine. 相似文献
998.
999.
1000.
Sohn Joon Hyuk Fukui Dai Nojiri Taro Minowa Kazuhiro Kimura Junpei Koyabu Daisuke 《Journal of Mammalian Evolution》2021,28(2):559-571
Journal of Mammalian Evolution - Anatomy of bat genital organs has been conventionally studied by gross and microscopic observations to date. Here, we employ both histological observation and... 相似文献