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排序方式: 共有378条查询结果,搜索用时 15 毫秒
371.
Alexander Z. Wei Lanyi N. Chen Marlana Orloff Charlotte E. Ariyan Maryam Asgari Christopher A. Barker Elizabeth Buchbinder Sunandana Chandra Kasey Couts Michael M. Frumovitz Andrew Futreal Jeffrey E. Gershenwald Ehab Y. Hanna Benjamin Izar Amy K. LeBlanc Mario M. Leitao Jr. Evan J. Lipson David Liu Martin McCarter Jennifer L. McQuade Yana Najjar Suthee Rapisuwon Sara Selig Alexander N. Shoushtari Iwei Yeh Gary K. Schwartz Jun Guo Sapna P. Patel Richard D. Carvajal 《Pigment cell & melanoma research》2023,36(6):542-556
Mucosal melanoma remains a rare cancer with high mortality and a paucity of therapeutic options. This is due in significant part to its low incidence leading to limited patient access to expert care and downstream clinical/basic science data for research interrogation. Clinical challenges such as delayed and at times inaccurate diagnoses, and lack of consensus tumor staging have added to the suboptimal outcomes for these patients. Clinical trials, while promising, have been difficult to activate and accrue. While individual institutions and investigators have attempted to seek solutions to such problems, international, national, and local partnership may provide the keys to more efficient and innovative paths forward. Furthermore, a mucosal melanoma coalition would provide a potential network for patients and caregivers to seek expert opinion and advice. The Melanoma Research Foundation Mucosal Melanoma Meeting (December 16, 2022, New York, USA) highlighted the current clinical challenges faced by patients, providers, and scientists, identified current and future clinical trial investigations in this rare disease space, and aimed to increase national and international collaboration among the mucosal melanoma community in an effort to improve patient outcomes. The included proceedings highlight the clinical challenges of mucosal melanoma, global clinical trial experience, basic science advances in mucosal melanoma, and future directions, including the creation of shared rare tumor registries and enhanced collaborations. 相似文献
372.
V V Surmak C E Sharapova E G Gurman N Ia Golovenko 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1990,40(1):79-84
It is shown that rats with a high degree of orienting-investigatory behaviour, low thresholds of emotional and pain sensitivity consume considerably more ethanol and rejected substances--urea and mustard--in comparison with low-active, less electrical pain-sensitive animals with a low degree of alcohol motivation. It is suggested that studying of characteristics of specialized appetite can be an important factor for prognostication of behaviour and role of individual in population. 相似文献
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Zhiyun Shi ;Yana Wang ;Zongji Li ;Zhaoyu Li ;Yang Bo ;Rui Ma ;Wei Zhao 《Acta biochimica et biophysica Sinica》2009,(1):79-85
Taeniid tapeworm Echinococcus granulosus is the causative agent of Echinococcosis, an important zoonosis with worldwide distribution. In this study, a diagnostic antigen P-29 was cloned from E. granulosus and expressed in Escherichia coil Sequence analysis showed that EgP-29 contains 717-bp open reading frame and encodes a protein of 238 amino acid residues with a predicted molecular weight of 27.1 kDa. The recombinant EgP-29 (rEgP-29) could be recognized with antimice sera in Western blotting. The specific antibody was detected by enzyme-linked immunosorbent assay. Mice vaccinated with rEgP-29 and challenged intrapero itoneally with E. granulosus protoscoleces revealed sig- nificant protective immunity of 96.6% (P〈0.05), compared with the control group. Thus, rEgP-29 protein is a promising candidate for an effective vaccine to prevent secondary echinococcosis. 相似文献
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Jiangbin Zhang Moritz H. Futscher Vincent Lami Felix U. Kosasih Changsoon Cho Qinying Gu Aditya Sadhanala Andrew J. Pearson Bin Kan Giorgio Divitini Xiangjian Wan Dan Credgington Neil C. Greenham Yongsheng Chen Caterina Ducati Bruno Ehrler Yana Vaynzof Richard H. Friend Artem A. Bakulin 《Liver Transplantation》2019,9(47)
377.