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991.
Sheng Yumeng Cao Manlin Liu Yiwen He Yiqing Zhang Guoliang Du Yan Gao Feng Yang Cuixia 《Molecular and cellular biochemistry》2021,476(9):3383-3391
Molecular and Cellular Biochemistry - Although luminal breast cancer cells are typically highly cohesive epithelial cells and have low invasive ability, many eventually develop metastasis. Until... 相似文献
992.
Wu Ying Jiang Lisha Zhang Lingling Liu Xia Yan Lina Luan Ting Rui Can Mao Zhiyuan Fan Chong Liu Yu Li Ping Zeng Xin 《Mycopathologia》2021,186(2):177-188
Mycopathologia - Vulvovaginal candidiasis (VVC) caused by Candida spp. affects 70–75% of women at least once during their lives. We aim to elucidate the potential mechanism of VVC and... 相似文献
993.
Zhou Rongmiao Li Yan Wang Na Niu Chaoxu Huang Xi Cao Shiru Huo Xiangran 《Molecular biology reports》2021,48(2):1485-1491
Molecular Biology Reports - DNA repair system plays a crucial role in maintaining genomic integrity and stability and in protecting against cancer. Poly(ADP-ribose) polymerase 1 (PARP1) functions... 相似文献
994.
995.
Liu Xinrong Liu Shuya Tang Yong Pu Zhengjia Xiao Hong Gao Jieying Yin Qi Jia Yan Bai Qunhua 《Neurochemical research》2021,46(6):1514-1539
Neurochemical Research - Gut microbial dysbiosis and alteration of gut microbiota composition in Parkinson's disease (PD) have been increasingly reported, no recognized therapies are available... 相似文献
996.
Huang Lihong Fu Qiang Dai Jia-Meng Yan Bing-Chao Wang Dawei Puno Pema-Tenzin Yue Jianbo 《Cell biology and toxicology》2021,37(5):695-713
Cell Biology and Toxicology - Autophagy is a conserved lysosomal degradation process, and abnormal autophagy has been associated with various pathological processes, e.g., neurodegeneration,... 相似文献
997.
Daisylyn Senna Tan Yanpu Chen Ya Gao Anastasia Bednarz Yuanjie Wei Vikas Malik Derek Hoi-Hang Ho Mingxi Weng Sik Yin Ho Yogesh Srivastava Sergiy Velychko Xiaoxiao Yang Ligang Fan Johnny Kim Johannes Graumann Gary D. Stormo Thomas Braun Jian Yan Hans R. Schler Ralf Jauch 《Molecular biology and evolution》2021,38(7):2854
998.
Our current research aimed to decipher the role and underlying mechanism with regard to miR-29b-3p involving in myocardial ischemia/reperfusion (I/R) injury. In the present study, cardiomyocyte H9c2 cell was used, and hypoxia/reoxygenation (H/R) model was established to mimic the myocardial I/R injury. The expressions of miR-29b-3p and pentraxin 3 (PTX3) were quantified deploying qRT-PCR and Western blot, respectively. The levels of LDH, TNF-α, IL-1β and IL-6 were detected to evaluate cardiomyocyte apoptosis and inflammatory response. Cardiomyocyte viability and apoptosis were examined employing CCK-8 assay and flow cytometry, respectively. Verification of the targeting relationship between miR-29b-3p and PTX3 was conducted using a dual-luciferase reporter gene assay. It was found that miR-29b-3p expression in H9c2 cells was up-regulated by H/R, and a remarkable down-regulation of PTX3 expression was demonstrated. MiR-29b-3p significantly promoted of release of inflammatory cytokines of H9c2 cells, and it also constrained the proliferation and promoted the apoptosis of H9c2 cells. Additionally, PTX3 was inhibited by miR-29b-3p at both mRNA and protein levels, and it was identified as a direct target of miR-29b-3p. PTX3 overexpression could reduce the inflammatory response, increase the viability of H9c2 cells, and inhibit apoptosis. Additionally, PTX3 counteracted the function of miR-29b-3p during the injury of H9c2 cells induced by H/R. In summary, miR-29b-3p was capable of aggravating the H/R injury of H9c2 cells by repressing the expression of PTX3. 相似文献
999.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unclear pathogenesis. We previously reported that syngenetic, activated lymphocyte-derived DNA (ALD-DNA) could robustly elicit macrophage activation, which plays an important role in the pathogenesis of murine lupus nephritis. In addition, extracellular HMGB1 obviously facilitated the accumulation of ALD-DNA in endosomes and promoted macrophage inflammation. While the detailed mechanism was still unknown. In this study, we found that HMGB1 could obviously change the DNA uptake pathways in macrophages. ALD-DNA alone was mainly uptake by the low efficient and unselective macropinocytosis, while extracellular HMGB1 potently promoted the more efficient and specific clathrin-/caveolin-1-dependent receptor-mediated endocytosis pathways, and led to the rapid and abundant aggregation of ALD-DNA in endosomes. This effect relied on the DNA binding ability and TLR2/TLR4 of HMGB1. Our study not only helped us to understand the promotion mechanisms of extracellular HMGB1 on ALD-DNA-induced macrophage inflammation, but also provided some clues to the pathogenesis of SLE. 相似文献
1000.
Ruiqi Liu Tingting Chen Xiao Yin Gaoqing Xiang Jing Peng Qingqing Fu Mengyuan Li Boxing Shang Hui Ma Guotian Liu Yuejin Wang Yan Xu 《The Plant journal : for cell and molecular biology》2021,106(6):1557-1570
Pathogens secrete a large number of effectors that manipulate host processes to create an environment conducive to pathogen colonization. However, the underlying mechanisms by which Plasmopara viticola effectors manipulate host plant cells remain largely unclear. In this study, we reported that RXLR31154, a P. viticola RXLR effector, was highly expressed during the early stages of P. viticola infection. In our study, stable expression of RXLR31154 in grapevine (Vitis vinifera) and Nicotiana benthamiana promoted leaf colonization by P. viticola and Phytophthora capsici, respectively. By yeast two-hybrid screening, the 23-kDa oxygen-evolving enhancer 2 (VpOEE2 or VpPsbP), encoded by the PsbP gene, in Vitis piasezkii accession Liuba-8 was identified as a host target of RXLR31154. Overexpression of VpPsbP enhanced susceptibility to P. viticola in grapevine and P. capsici in N. benthamiana, and silencing of NbPsbPs, the homologs of PsbP in N. benthamiana, reduced P. capcisi colonization, indicating that PsbP is a susceptibility factor. RXLR31154 and VpPsbP protein were co-localized in the chloroplast. Moreover, VpPsbP reduced H2O2 accumulation and activated the 1O2 signaling pathway in grapevine. RXLR31154 could stabilize PsbP. Together, our data revealed that RXLR31154 reduces H2O2 accumulation and activates the 1O2 signaling pathway through stabilizing PsbP, thereby promoting disease. 相似文献