97.
Ginseng and the seed of
Zizyphus jujuba var.
spinosa, which are traditional Chinese medicinal materials, were often used in ancient Chinese recipes as a pair of medicines. They can replenish the primordial qi and tonify the spleen. This study investigated the effects of ginseng and the seed of
Zizyphus jujuba var.
spinosa (
GS) extract on gut microbiota diversity in rats with spleen deficiency syndrome (
SDS). A total of 52 compounds (including 16 flavonoids, 35 saponins, and 1 alkaloid) were identified and analyzed from the
GS extract by UPLC‐Q‐Orbitrap‐MS/MS. The
GS extract significantly increased the relative abundance of Firmicutes and Bacteroidetes in rats with
SDS but decreased that of Proteobacteria and Actinobacteria. At the genus level, the
GS extract significantly increased the relative abundance of
Lactobacillus and
Bifidobacterium in rats with
SDS but decreased that of
Streptococcus,
Escherichia‐Shigella,
Veillonella, and
Enterococcus. In addition, the
GS extract influenced glucose and amino acid metabolism. In summary, the results showed that the
GS extract changed the structure and diversity of gut microbiota in rats with
SDS and balanced the metabolic process.
相似文献