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991.
Panov V. A. Vasilyak L. M. Vetchinin S. P. Deshevaya E. A. Pecherkin V. Ya. Son E. E. 《Plasma Physics Reports》2019,45(5):517-521
Plasma Physics Reports - Inactivation of spore microorganisms on a dielectric surface by a dielectric barrier discharge with plane electrodes was studied experimentally. It is shown that, at an... 相似文献
992.
Astakhova T. M. Bozhok G. A. Alabedal’karim N. M. Karpova Ya. D. Lyupina Yu. V. Ushakova E. M. Legach E. I. Bondarenko T. P. Sharova N. P. 《Russian Journal of Developmental Biology》2019,50(5):261-267
Russian Journal of Developmental Biology - The aim of this work is to investigate the dynamics for the ovarian tissue engraftment of inbred August rats transplanted to outbred Wistar rats and vice... 相似文献
993.
Stefanovskii A. M. Dremin M. M. Kakurin A. M. Kislov A. Ya. Notkin G. E. Pavlov Yu. D. Sushkov A. V. 《Plasma Physics Reports》2019,45(12):1142-1163
Plasma Physics Reports - Experimental data on plasma cooling during slow discharge disruptions at the T-10 tokamak are analyzed. It is shown that, in the initial phase of thermal quench at T-10,... 相似文献
994.
Plasma Physics Reports - In this work, a one-dimensional fluid model is established to study the effects of frequency on (He + O2) dielectric barrier discharge. As the frequency increases... 相似文献
995.
Deineka V. I. Kul’chenko Ya. Yu. Blinova I. P. Chulkov A. N. Deineka L. A. 《Russian Journal of Bioorganic Chemistry》2019,45(7):895-899
Russian Journal of Bioorganic Chemistry - The anthocyanin composition of five purple leaves cultivars of Ocimum basilicum L. was investigated by reversed-phase HPLC with mass-spectrometric... 相似文献
996.
Lanxia Meng Xingchen Guo Xilin Yang Hongyue Liu Mosheng Yu Yingliang Wu Zhanyong Zhu 《Journal of biochemical and molecular toxicology》2019,33(8)
Sustained infection and chronic inflammation are the most common features and complex mechanisms of diabetic foot disease. In this study, we examined the expression and functional roles of human endogenous α defensins in diabetic foot ulcer. The expression levels of human α defensins HNP1, HNP3, and HNP4 were significantly higher in the wound center than the edge of diabetic foot ulcers. And the inflammatory cytokine interleukin IL‐8 (IL‐8) was also highly expressed in wound exudates. In human foreskin fibroblasts, these human α defensins were found only slightly to affect IL‐8 expression directly. hemoglobin A1C (HbA1c) is the main clinical indicator of diabetic foot disease. Advanced glycation end products of bovine serum albumin (AGE‐BSA), as HbA1c analogue, was found to promote IL‐8 expression. Human α defensins, in the presence of AGE‐BSA, further significantly promoted IL‐8 expression. These findings showed that human α defensins aggravated the inflammatory response in diabetic foot ulcers patients, providing new insights in to the poor healing of diabetic foot ulcers. 相似文献
997.
998.
The aim of this study was to explore the mechanisms of brain damage induced by the combined treatment of mice with 1,2‐dichloroethane (1,2‐DCE) and ethanol. Mice were divided into control group; 1,2‐DCE‐intoxicated group; ethanol‐treated group; and low‐, medium‐, and high‐dose combined treatment groups. Histological observations along with brain organ coefficients and water content were used to measure the brain damage directly and indirectly. The levels of nonprotein sulfhydryls, malondialdehyde (MDA), and superoxide dismutase activity were used as parameters to evaluate oxidative stress in the brain. Protein and messenger RNA (mRNA) levels of cytochrome P450 2E1 (CYP2E1), zonula occludens‐1 (occludin and zo‐1), aquaporin‐4 (AQP4), nuclear factor erythroid 2‐related factor 2 (Nrf2), heme oxygenase (HO)‐1, and the γ‐glutamyl cysteine synthetase catalytic and modulatory subunits (γ‐GCSc, GR, and γ‐GCSm) in the brain were examined by Western blot analysis and quantitative polymerase chain reaction analysis, respectively. Effects of the combined treatment of 1,2‐DCE and ethanol were evaluated by analysis of variance with a factorial design. The results suggested that combined exposure to ethanol and 1,2‐DCE synergistically increased CYP2E1 protein and mRNA levels, accelerated the metabolism of ethanol and 1,2‐DCE in the brain tissue, induced high production of reactive oxygen species (ROS), and increased MDA levels, thereby damaging the blood‐brain barrier and causing obvious pathological changes in brain tissue. However, the increased level of ROS activated the Nrf2 signal transduction pathway, promoting the expression of HO‐1 and glutathione‐related antioxidant enzymes in the brain to protect the cells from oxidative damage. 相似文献
999.
In this review, we summarize the rational design and versatile application of organic/inorganic hybrid gene carriers as multifunctional delivery systems. Organic/inorganic nanohybrids with both organic and inorganic components in one nanoparticle have attracted intense attention because of their favorable properties. Particularly, nanohybrids comprising cationic polymers and inorganic nanoparticles are considered to be promising candidates as multifunctional gene delivery systems. In this review, we begin with an introduction of gene delivery and gene carriers to demonstrate the incentive for fabricating nanohybrids as multifunctional carriers. Next, the construction strategies and morphology effects of organic/inorganic hybrid gene carriers are summarized and discussed. Both sections provide valuable information for the design and synthesis of hybrid gene carriers with superior properties. Finally, an overview is provided of the application of nanohybrids as multifunctional gene carriers. Diverse therapies and versatile imaging‐guided therapies have been achieved via the rational design of nanohybrids. In addition to a simple combination of the functions of organic and inorganic components, the performances arising from the synergistic effects of both components are considered to be more intriguing. In summary, this review might offer guidance for the understanding of organic/inorganic nanohybrids as multifunctional gene delivery systems. 相似文献
1000.
Plant Ecology - Knowledge of the responses of climbing plants to disturbance is important in understanding the ecology of climber but still lacking a general agreement. The present study quantified... 相似文献