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Liu Xia Ruan Zhi Shao Xing-cheng Feng Hong-xuan Wu Lei Wang Wei Wang Hong-min Mu Hong-yan Zhang Ru-jun Zhao Wei-min Zhang Hai-yan Zhang Nai-xia 《Neurochemical research》2021,46(3):699-700
Neurochemical Research - In the original version of this article, unfortunately the Fig. 3C and 3F were published with incorrect version. The correct version of the Fig. 3C and 3F... 相似文献
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Xiao Dong Shixiang Sun Lei Zhang Seungsoo Kim Zhidong Tu Cristina Montagna Alexander Y. Maslov Yousin Suh Tao Wang Judith Campisi Jan Vijg 《Aging cell》2021,20(6)
Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age‐related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome‐wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging. 相似文献
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Wenhua Lei Junli Li Changming Li Li Chen Fangyang Huang Dan Xiao Jialiang Zhang Jiahao Zhao Guoyong Li Tianyi Qu Hao Zhou Yanbiao Liao Mao Chen 《Journal of cellular and molecular medicine》2021,25(7):3182-3193
MARCH5 is a critical regulator of mitochondrial dynamics, apoptosis and mitophagy. However, its role in cardiovascular system remains poorly understood. This study aimed to investigate the role of MARCH5 in endothelial cell (ECs) injury and the involvement of the Akt/eNOS signalling pathway in this process. Rat models of myocardial infarction (MI) and human cardiac microvascular endothelial cells (HCMECs) exposed to hypoxia (1% O2) were used in this study. MARCH5 expression was significantly reduced in ECs of MI hearts and ECs exposed to hypoxia. Hypoxia inhibited the proliferation, migration and tube formation of ECs, and these effects were aggravated by knockdown of MARCH5 but antagonized by overexpressed MARCH5. Overexpression of MARCH5 increased nitric oxide (NO) content, p-eNOS and p-Akt, while MARCH5 knockdown exerted the opposite effects. The protective effects mediated by MARCH5 overexpression on ECs could be inhibited by eNOS inhibitor L-NAME and Akt inhibitor LY294002. In conclusion, these results indicated that MARCH5 acts as a protective factor in ischaemia/hypoxia-induced ECs injury partially through Akt/eNOS pathway. 相似文献
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Deng-Sen Xiong Ya-Bin Yang Bin-Yuan Hu Cui-Ping Miao Yong-Liang Wang Jin-Mei Zou Lei Li Yi-Qing Li Xiao-Dong Luo Li-Xing Zhao 《化学与生物多样性》2021,18(3):e2000964
Endophytic fungi play important roles for host's stress tolerance including invasion by pathogenic microbes. Small molecules are common weapons in the microbe–microbe interactions. Panax notoginseng is a widely used traditional Chinese medicinal plant and harbors many endophytes, some exert functions against pathogens. Here, we report six new compounds named myrothins A–F ( 1 – 6 ) produced by Myrothecium sp. BS-31, an endophyte isolated from P. notoginseng, and their antifungal activities against pathogenic fungi causing host root-rot disease. Their structures were elucidated with analysis of spectroscopic data including 1D and 2D NMR, HR-ESI-MS. Myrothins B ( 2 ) and E ( 5 ) showed the weak activity against Fusarium oxysporum and Phoma herbarum, and myrothins F ( 6 ) showed weak activity against F. oxysporum. 相似文献
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Yong-Liang Wang Bin-Yuan Hu Meng-An Qian Zi-Hang Wang Jing-Mei Zou Xu-Yan Sang Lei Li Xiao-Dong Luo Li-Xing Zhao 《化学与生物多样性》2021,18(9):e2100460
A new compound named koninginin W ( 1 ) and four known polyketides ( 2 – 5 ) were isolated from endophytic fungus Trichoderma koningiopsis YIM PH30002 of Panax notoginseng. The structures of 1 - 5 , including absolute configuration of 1 , were elucidated on the detailed analysis of the HR-ESI-MS, 1D and 2D NMR, and X-ray crystallographic data. Koninginin W ( 1 ) presented weak antibacterial activity against Escherichia coli, Bacillus subtilis and Salmonella typhimurium. 相似文献