全文获取类型
收费全文 | 9868篇 |
免费 | 883篇 |
国内免费 | 838篇 |
专业分类
11589篇 |
出版年
2024年 | 27篇 |
2023年 | 156篇 |
2022年 | 334篇 |
2021年 | 576篇 |
2020年 | 402篇 |
2019年 | 439篇 |
2018年 | 424篇 |
2017年 | 308篇 |
2016年 | 430篇 |
2015年 | 609篇 |
2014年 | 782篇 |
2013年 | 757篇 |
2012年 | 927篇 |
2011年 | 782篇 |
2010年 | 540篇 |
2009年 | 423篇 |
2008年 | 460篇 |
2007年 | 493篇 |
2006年 | 408篇 |
2005年 | 341篇 |
2004年 | 303篇 |
2003年 | 233篇 |
2002年 | 201篇 |
2001年 | 175篇 |
2000年 | 156篇 |
1999年 | 153篇 |
1998年 | 71篇 |
1997年 | 69篇 |
1996年 | 73篇 |
1995年 | 52篇 |
1994年 | 63篇 |
1993年 | 51篇 |
1992年 | 75篇 |
1991年 | 59篇 |
1990年 | 39篇 |
1989年 | 51篇 |
1988年 | 29篇 |
1987年 | 33篇 |
1986年 | 24篇 |
1985年 | 25篇 |
1984年 | 8篇 |
1983年 | 11篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 5篇 |
1979年 | 6篇 |
1978年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
941.
Plasma folate levels in early to mid pregnancy after a nation‐wide folic acid supplementation program in areas with high and low prevalence of neural tube defects in china
下载免费PDF全文
![点击此处可从《Birth defects research. Part A, Clinical and molecular teratology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
942.
943.
944.
945.
Attenuation of microRNA‐16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy
下载免费PDF全文
![点击此处可从《Journal of cellular and molecular medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
946.
Next-generation sequencing technology allows simultaneous analysis of multiple susceptibility genes for clinical cancer genetics. In this study, multiplex genetic testing was conducted in a Chinese family with multiple cases of cancer to determine the variations in cancer predisposition genes. The family comprises a mother and her five daughters, of whom the mother and the eldest daughter have cancer and the secondary daughter died of cancer. We conducted multiplex genetic testing of 90 cancer susceptibility genes using the peripheral blood DNA of the mother and all five daughters. WRN frameshift mutation is considered a potential pathogenic variation according to the guidelines of the American College of Medical Genetics. A novel WRN frameshift mutation (p.N1370Tfs*23) was identified in the three cancer patients and in the youngest unaffected daughter. Other rare non-synonymous germline mutations were also detected in DICER and ELAC2. Functional mutations in WRN cause Werner syndrome, a human autosomal recessive disease characterized by premature aging and associated with genetic instability and increased cancer risk. Our results suggest that the WRN frameshift mutation is important in the surveillance of other members of this family, especially the youngest daughter, but the pathogenicity of the novel WRN frameshift mutation needs to be investigated further. Given its extensive use in clinical genetic screening, multiplex genetic testing is a promising tool in clinical cancer surveillance. 相似文献
947.
Qing Ye Shi-qiang Shang Ai-min Liu Ting Zhang Hong-qiang Shen Xue-jun Chen Jian-hua Mao 《PloS one》2015,10(5)
This study aimed to assess the relevance of laboratory tests in Henoch-Schönlein purpura nephritis (HSPN) classification, and determine accurate classification factors. This prospective study included 694 HSPN patients who underwent ultrasound-guided percutaneous renal biopsy (PRB). Renal specimens were scored according to International Study of Kidney Disease in Children (ISKDC) classification. Meanwhile, blood samples were immediately collected for laboratory examination. The associations between laboratory parameters and HSPN classification were assessed. Significant differences in levels of serum Th1/Th2 cytokines, immunoglobulins, T-lymphocyte subsets, complement, and coagulation markers were obtained between HSPN patients and healthy children. Interestingly, 24h urinary protein (24h-UPRO) levels and urine protein/urine creatinine ratios could determine HPSN grade IIb, IIIa, and IIIb incidences, with areas under ROC curve of 0.767 and 0.731, respectively. At 24h-UPRO >580.35mg/L, prediction sensitivity and specificity were 75.2% and 70.0%, respectively. These values became 53.0% and 82.3%, respectively, with 24h-UPRO exceeding 1006.25mg/L. At urine protein/urine creatinine > 0.97, prediction sensitivity and specificity were 65.5% and 67.2%, respectively, values that became 57.4% and 80.0%, respectively, at ratios exceeding 1.2. Cell and humoral immunity, coagulation and fibrinolytic systems are all involved in the pathogenesis of HSPN, and type I hypersensitivity may be the disease trigger of HSPN. 24h-UPRO levels and urine protein/creatinine ratios could probably forecast the pathological classification of HSPN. 相似文献
948.
Background
Aortocaval fistula (AV) in rat is a unique model of volume-overload congestive heart failure and cardiac hypertrophy. Living donor kidney transplantation is regarded as beneficial to allograft recipients and not particularly detrimental to the donors. Impact of AV on animals with mild renal dysfunction is not fully understood. In this study, we explored the effects of AV in unilateral nephrectomized (UNX) rats.Methods
Adult male Sprague-Dawley (SD) rats were divided into Sham (n = 10), UNX (right kidney remove, n = 10), AV (AV established between the levels of renal arteries and iliac bifurcation, n = 18) and UNX+AV (AV at one week after UNX, n = 22), respectively. Renal outcome was measured by glomerular filtration rate, effective renal plasma flow, fractional excretion of sodium, albuminuria, plasma creatinine, and cystatin C. Focal glomerulosclerosis (FGS) incidence was evaluated by renal histology. Cardiac function was measured by echocardiography and hemodynamic measurements.Results
UNX alone induced compensatory left kidney enlargement, increased plasma creatinine and cystatin C levels, and slightly reduced glomerular filtration rate and increased FGS. AV induced significant cardiac enlargement and hypertrophy and reduced cardiac function and increased FGS, these changes were aggravated in UNX+AV rats.Conclusions
Although UNX only induces minor renal dysfunction, additional chronic volume overload placement during the adaptation phase of the remaining kidney is associated with aggravated cardiac dysfunction and remodeling in UNX rats, suggesting special medical care is required for UNX or congenital monokidney subjects in case of chronic volume overload as in the case of pregnancy and hyperthyroidism to prevent further adverse cardiorenal events in these individuals. 相似文献949.
950.
Yuying Su Wei Sun Chenqiong Wang Xuefen Wu Ye Miao Hui Xiong Lin Bai Lingli Dong 《PloS one》2015,10(4)