Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019

Since late 2011, outbreaks of pseudorabies virus(PRV) have occurred in southern China causing major economic losses to the pig industry. We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics. Here, we analyzed samples from intensive pig farms in eastern China between 2017 and 2019, and sequenced the main glycoproteins(gB, gC, gD, and gE) to study the evolution characteristics of PRV. Based on the g C gene, we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic. In addition,we detected inter-and intra-clade recombination; in particular, inter-clade recombination in the g B genes of strains FJ-ZXF and FJ-W2, which were recombinant with clade 1 strains. We also found specific amino-acid changes and positively selected sites, possibly associated with functional changes. This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV.     

Flexible Na/K‐Ion Full Batteries from the Renewable Cotton Cloth–Derived Stable,Low‐Cost,and Binder‐Free Anode and Cathode

Flexible Na/K‐ion batteries (NIBs/KIBs) exhibit great potential applications and have drawn much attention due to the continuous development of flexible electronics. However, there are still many huge challenges, mainly the design and construction of flexible electrodes (cathode and anode) with outstanding electrochemical properties. In this work, a unique approach to prepare flexible electrode is proposed by utilizing the commercially available cotton cloth–derived carbon cloth (CC) as a flexible anode and the substrate of a cathode. The binder‐free, self‐supporting, and flexible cathodes (FCC@N/KPB) are prepared by growing Prussian blue microcubes on the flexible CC (FCC). Na/K‐ion full batteries (FCC//FCC@N/KPB) are assembled by using FCC and FCC@N/KPB as anode and cathode, respectively. Electrochemical performance, mechanical flexibility, and practicability of FCC//FCC@N/KPB Na/K‐ion full batteries are evaluated in both coin cells and flexible pouch cells, demonstrating their superior energy‐storage properties (excellent rate performance and cycling stability) and remarkable flexibility (they can work under different bending states). This work provides a new and profound strategy to design flexible electrodes, promoting the development of flexible NIBs/KIBs to be practical and sustainable.     

Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents

Various 3-amino-, 3-aryloxy- and alkoxy-6-arylpyridazines have been synthesized by an electrochemical reductive cross-coupling between 3-amino-, 3-aryloxy- or 3-alkoxy-6-chloropyridazines and aryl or heteroaryl halides. In vitro antiproliferative activity of these products was evaluated against a representative panel of cancer cell lines (HuH7, CaCo-2, MDA-MB-231, HCT116, PC3, NCI-H727, HaCaT) and oncogenicity prevention of the more efficient derivatives was highlighted on human breast cancer cell line MDA-MB 468-Luc prior establishing their interaction with p44/42 and Akt-dependent signaling pathways.     

Recognition of the prioritized types and individual of pharmaceuticals and personal care products (PPCPs) in the drinking water of Shanghai and a health risk assessment

Pharmaceuticals and personal care products (PPCPs) exist and are often grouped into categories according to their functional mechanism and effect on human health. In this study, six types of PPCPs were detected and characterized in the drinking water of Shanghai, covering 35 water treatment plants. The PPCPs concentrations were ranged from 2.57 ng/L to 19.4 ng/L and over 10 ng/L in nearly half of the samples. Hormones, blockers, and veterinary drugs were considered to contribute negligibly to the overall pollution from PPCPs for their low concentrations. However, dicyclohexylamine and psycholeptics were detected in all samples, with a maximum concentration of 11.8 ng/L, 7.82 ng/L, and 9.07 ng/L for dicyclohexylamine, sertraline, and sulpiride, respectively. In addition, high toxicity antitumor drug cyclophosphamide was detected in one-third of the samples and the highest concentration was 3.72 ng/L.

In all, the four PPCPs evaluated accounted for over 80% of the detected PPCPs levels. Therefore, it was determined that the major PPCPs are contributing to water pollution in the region. While these compounds do not pose a potential human health risk at their present levels, close attention should be paid to the use of these PPCPs and their discharge into drinking water source.     

Role of Chitosan in the Regulation of the Growth,Antioxidant System and Photosynthetic Characteristics of Maize Seedlings under Cadmium Stress

Russian Journal of Plant Physiology - Cadmium (Cd) pollution was becoming more and more serious; there is an urgent need for an effective solution to inhibit the harm of cadmium stress. Chitosan...