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931.
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933.
Xingguang Cai Lidan Sun Yuxuan Dai Yosefa Avraham Chunxia Liu Jing Han Yuan Liu Dazhi Feng Wenlong Huang Hai Qian 《Bioorganic & medicinal chemistry》2018,26(9):2599-2609
Glucagon-like peptide-1 is a potent hypoglycemic hormone with beneficial properties for the treatment of diabetes. However, its half-life is short because the rapid metabolic degradation. This study aims to prolong the half-life of glucagon-like peptide-1 through conjugation with the fatty acid side chain which helps the conjugates to interact with the albumin. Firstly, we chose two optimized polypeptide chains which have tremendous hypoglycemic effect named Cys17-Gly8-GLP-1(7-36)-NH2 and Cys37-Gly8-GLP-1(7-37)-NH2, and various fatty acid chains were modified. All conjugates preserved relatively strong GLP-1R activation and I-6 behaved best in glucose-lowering ability. The prolonged antidiabetic effects of I-6 were further confirmed by hypoglycemic efficacy test in vivo. Meanwhile, once daily injection of I-6 to diabetic mice achieved long-term beneficial effects on glucose tolerance, body weight and blood chemistry. It is concluded that I-6 is a promising agent for further investigation of its potential to treat obese patients with diabetes. 相似文献
934.
The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition during Root Hair Tip Growth 总被引:1,自引:0,他引:1
Sébastjen Schoenaers Daria Balcerowicz Gordon Breen Kristine Hill Malgorzata Zdanio Grégory Mouille Tara J. Holman Jaesung Oh Michael H. Wilson Natalia Nikonorova Lam Dai Vu Ive De Smet Ranjan Swarup Winnok H. De Vos Isabel Pintelon Dirk Adriaensen Claire Grierson Malcolm J. Bennett Kris Vissenberg 《Current biology : CB》2018,28(5):722-732.e6
935.
Steven D. Fidanze Dachun Liu Robert A. Mantei Lisa A. Hasvold John K. Pratt George S. Sheppard Le Wang James H. Holms Yujia Dai Ana Aguirre Andrew Bogdan Justin D. Dietrich Jasmina Marjanovic Chang H. Park Charles W. Hutchins Xiaoyu Lin Mai H. Bui Xiaoli Huang Keith F. McDaniel 《Bioorganic & medicinal chemistry letters》2018,28(10):1804-1810
Novel conformationally constrained BET bromodomain inhibitors have been developed. These inhibitors were optimized in two similar, yet distinct chemical series, the 6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-ones (A) and the 1-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-ones (B). Each series demonstrated excellent activity in binding and cellular assays, and lead compounds from each series demonstrated significant efficacy in in vivo tumor xenograft models. 相似文献
936.
Compound C induces protective autophagy in human cholangiocarcinoma cells via Akt/mTOR‐independent pathway 下载免费PDF全文
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939.
Expression plasticity and evolutionary changes extensively shape the sugar‐mimic alkaloid adaptation of nondigestive glucosidase in lepidopteran mulberry‐specialist insects 下载免费PDF全文
Liangen Shi Xiangping Dai Yajie Chen Hongqing Xie Min Feng Yuyin Chen Huabing Wang 《Molecular ecology》2018,27(13):2858-2870
940.
Supercapacitors: Large‐Scale Conductive Yarns Based on Twistable Korean Traditional Paper (Hanji) for Supercapacitor Applications: Toward High‐Performance Paper Supercapacitors (Adv. Energy Mater. 27/2018) 下载免费PDF全文