全文获取类型
收费全文 | 5350篇 |
免费 | 437篇 |
国内免费 | 365篇 |
专业分类
6152篇 |
出版年
2024年 | 9篇 |
2023年 | 60篇 |
2022年 | 153篇 |
2021年 | 241篇 |
2020年 | 168篇 |
2019年 | 216篇 |
2018年 | 196篇 |
2017年 | 118篇 |
2016年 | 230篇 |
2015年 | 322篇 |
2014年 | 360篇 |
2013年 | 381篇 |
2012年 | 467篇 |
2011年 | 479篇 |
2010年 | 281篇 |
2009年 | 268篇 |
2008年 | 311篇 |
2007年 | 285篇 |
2006年 | 235篇 |
2005年 | 188篇 |
2004年 | 167篇 |
2003年 | 162篇 |
2002年 | 126篇 |
2001年 | 94篇 |
2000年 | 89篇 |
1999年 | 65篇 |
1998年 | 30篇 |
1997年 | 43篇 |
1996年 | 54篇 |
1995年 | 30篇 |
1994年 | 27篇 |
1993年 | 25篇 |
1992年 | 48篇 |
1991年 | 29篇 |
1990年 | 22篇 |
1989年 | 18篇 |
1988年 | 24篇 |
1987年 | 21篇 |
1986年 | 13篇 |
1985年 | 13篇 |
1984年 | 8篇 |
1983年 | 17篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1980年 | 5篇 |
1977年 | 4篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有6152条查询结果,搜索用时 0 毫秒
891.
Xue Kong Juan Li Yanru Li Weili Duan Qiuchen Qi Tiantian Wang Qifeng Yang Lutao Du Haiting Mao Chuanxin Wang 《Cell death & disease》2021,12(7)
Breast cancer is the major cause of cancer death worldwide in women. Patients with metastasis have poor prognosis and the mechanisms of breast cancer metastasis are not completely understood. Long non-coding RNAs (lncRNAs) have been shown to have crucial roles in breast cancer development and progression. However, the underlying mechanisms by which lncRNA-driven breast cancer metastasis are unknown. The main objective of this paper is to explore a functional lncRNA and its mechanisms in breast cancer. Here we identified a novel lncRNA AC073352.1 that was significantly upregulated in breast cancer tissues and was associated with advanced TNM stages and poor prognosis in breast cancer patients. In addition, AC073352.1 was found to promote the migration and invasion of breast cancer cells in vitro and enhance breast cancer metastasis in vivo. Mechanistically, we elucidated that AC073352.1 interacted with YBX1 and stabilized its protein expression. Knock down of YBX1 reduced breast cancer cell migration and invasion and could partially reverse the stimulative effects of AC073352.1 overexpressed on breast cancer metastasis. Moreover, AC073352.1 might be packaged into exosomes by binding to YBX1 in breast cancer cells resulting in angiogenesis. Collectively, our results demonstrated that AC073352.1 promoted breast cancer metastasis and angiogenesis via binding YBX1, and it could serve as a promising, novel biomarker for prognosis and a therapeutic target in breast cancer.Subject terms: Breast cancer, Cell invasion, Long non-coding RNAs 相似文献
892.
Isabella Y. Kong Stephanie Trezise Amanda Light Izabela Todorovski Gisela Mir Arnau Sreeja Gadipally David Yoannidis Kaylene J. Simpson Xueyi Dong Lachlan Whitehead Jessica C. Tempany Anthony J. Farchione Amania A. Sheikh Joanna R. Groom Kelly L. Rogers Marco J. Herold Vanessa L. Bryant Matthew E. Ritchie Simon N. Willis Ricky W. Johnstone Philip D. Hodgkin Stephen L. Nutt Stephin J. Vervoort Edwin D. Hawkins 《Cell death and differentiation》2022,29(12):2519
893.
Chimeric antigen receptor-modified T (CAR-T) cells have brought a major breakthrough in tumor immunotherapy. As research continues to develop, CAR-T therapies have shown certain limitations, such as graft-versus-host reaction and the long time required to generate CAR-T cells. Natural killer (NK) cells, as the first line of defense against pathogens and cancer cells, belong to the innate immune system and have the advantage of being able to replace T cells, and can be used to prepare engineered chimeric antigen receptor-modified NK (CAR-NK) cells. The biological characteristics of CAR-NK cells, their sources, and the latest research progress and prospects for tumor treatment in China and worldwide are presented in this review. 相似文献
894.
Jia Liu Peiyan Kong Lidan Zhu Shichun Gao Huanfeng Liu Lu Wang Cheng Zhang Li Gao Xi Zhang Lei Gao 《Blood and Genomics》2023,4(1):55-60
This study aims to retrospectively analyze the efficacy of penciclovir in the prevention of viral infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Ninety-six patients with allo-HSCT were enrolled, who were treated at the Medical Center of Hematology of Xinqiao Hospital from June 2020 to September 2021. The experimental and control groups were treated with penciclovir and acyclovir, respectively, to prevent viral infection. By February 2022, the infection rates of cytomegalovirus, BK virus, JC virus, and Epstein-Barr virus (EBV) in the experimental group and the control group were 18.8% and 39.06% (P<0.05), 28.1% and 25% (P>0.05), 6.2% and 7.81% (P>0.05), 21.8% and 23.43% (P>0.05), respectively. The infection-related urinary system symptoms of the experimental group and the control group occurred in 4 and 9 patients, respectively, of which 3 and 9 patients died, respectively. Penciclovir can significantly reduce the cytomegalovirus infection rate after allo-HSCT and has better preventive effects than acyclovir without obvious side effects. The effectiveness and safety of penciclovir will be further verified in the future. 相似文献
895.
896.
897.
生物质谱技术在糖蛋白结构分析中的应用 总被引:3,自引:0,他引:3
生物质谱包括基质辅助激光解吸附飞行时间质谱及电喷雾质谱被广泛应用于生物样品如多肽、蛋白质及核酸的分析,由于这种具有软电离方式的质谱具有极高的灵敏度及准确度,目前也被成功地用于糖蛋白的结构分析,与普通的化学方法相比,质谱法快速、简单,结合网上数据库检索、凝集素亲和提取、二维凝胶电泳以及靶上直接酶切等新方法,可以提供糖蛋白的一级结构乃至高级结构的信息。 相似文献
898.
899.