爱贝芙在修复面部软组织凹陷中的应用

目的:探讨爱贝芙在修复面部凹陷中的疗效.方法:根据凹陷程度估计爱贝芙用量,然后在面部凹陷部位的真皮网状层或真皮与皮下脂肪交界平面注射爱贝芙,轻压、按摩平整,而后局部用胶布固定三天.结果:爱贝芙能明显修复眼睑沟、鼻梁、鼻翼塌陷及先天的软组织凹陷,患者满意,对凹陷瘢痕虽能矫正凹陷,但无法改变瘢痕已有的色素改变,对唇的效果较差.结论:爱贝芙可以用来修复面部大部分软组织凹陷,且痛苦小、恢复快.     

两种多糖对日本沼虾酚氧化酶活力的影响

在饲料中分别添加 1‰的云芝多糖和虫草多糖 ,对日本沼虾进行投喂 ,通过连续测定日本沼虾血清中的酚氧化酶活力 ,研究两种多糖对日本沼虾免疫机能的作用。结果表明 ,在平均水温为 2 3 8℃± 3 8℃时 ,云芝组、虫草组分别较对照组提高了 34 52 %、84 62 % ;在平均水温为 1 0 8± 2 4℃时 ,云芝组和虫草组分别较对照组提高了30 0 2 %、5 1 2 % ,因而云芝多糖和虫草多糖能明显地增强日本沼虾血清的酚氧化酶活力。另经实验表明 ,在王雷所确立的酚氧化酶活力的检测条件下 ,其PO活力为 8 3units/mL ,而在Horowitz所确立的检测条件下 ,其PO活力为2 90units/mL ,并且后者检测方法重复性好 ,能较好地反映日本沼虾的免疫状态。     

Biobased poly(propylene sebacate) as shape memory polymer with tunable switching temperature for potential biomedical applications

From the point of better biocompatibility and sustainability, biobased shape memory polymers (SMPs) are highly desired. We used 1,3-propanediol, sebacic acid, and itaconic acid, which have been industrially produced via fermentation or extraction with large quantities as the main raw materials for the synthesis of biobased poly(propylene sebacate). Diethylene glycol was used to tailor the flexibility of the polyester. The resulted polyesters were found to be promising SMPs with excellent shape recovery and fixity (near 100% and independent of thermomechanical cycles). The switching temperature and recovery speed of the SMPs are tunable by controlling the composition of the polyesters and their curing extent. The continuously changed switching temperature ranging from 12 to 54 °C was realized. Such temperature range is typical for biomedical applications in the human body. The molecular and crystalline structures were explored to correlate to the shape memory behavior. The combination of potential biocompatibility and biodegradability of the biobased SMPs makes them suitable for fabricating biomedical devices.     

AnnexinA7 promotes epithelial–mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and metastasis is the major cause of the high mortality of HCC. In this study, we identified that AnnexinA7 (ANXA7) and Sorcin (SRI) are overexpressed and interacting proteins in HCC tissues and cells. In vitro functional investigations revealed that the interaction between ANXA7 and SRI regulated epithelial–mesenchymal transition (EMT), and then affected migration, invasion, and proliferation in HCC cells. Furthermore overexpression/knockdown of ANXA7 was remarkably effective in promoting/inhibiting tumorigenicity and EMT in vivo. Altogether, our study unveiled a mechanism that ANXA7 promotes EMT by interacting with SRI and further contributes to the aggressiveness in HCC, which provides a novel potential therapeutic target for preventing recurrence and metastasis in HCC.Subject terms: Medical research, Genetics research     

Inhibition of fatty acid synthase suppresses U-2 OS cell invasion and migration via downregulating the activity of HER2/PI3K/AKT signaling pathway in vitro

FASN plays an important role in the malignant phenotype of various tumors. Our previous studies show that inhibition FASN could induce apoptosis and inhibit proliferation in human osteosarcoma (OS) cell in vivo and vitro. The aim in this study was to investigate the effect of inhibition FASN on the activity of HER2/PI3K/AKT axis and invasion and migration of OS cell. The expression of FASN, HER2 and p-HER2(Y1248) proteins was detected by immunohistochemistry in OS tissues from 24 patients with pulmonary metastatic disease, and the relationship between FASN and p-HER2 as well as HER2 was investigated. The results showed that there was a positive correlation between FASN and HER2 as well as p-HER2 protein expression. The U-2 OS cells were transfected with either the FASN specific RNAi plasmid or the negative control RNAi plasmid. FASN mRNA was measured by RT-PCR. Western blot assays was performed to examine the protein expression of FASN, HER2, p-HER2(Y1248), PI3K, Akt and p-Akt (Ser473). Migration and invasion of cells were investigated by wound healing and transwell invasion assays. The results showed that the activity of HER2/PI3K/AKT signaling pathway was suppressed by inhibiting FASN. Meanwhile, the U-2OS cells migration and invasion were also impaired by inhibiting the activity of FASN/HER2/PI3K/AKT. Our results indicated that inhibition of FASN suppresses OS cell invasion and migration via down-regulation of the “HER2/PI3K/AKT” axis in vitro. FASN blocker may be a new therapeutic strategy in OS management.     

Sesame Utilization in China: New Archaeobotanical Evidence from Xinjiang

Sesame Utilization in China: New Archaeobotanical Evidence from Xinjiang. A cache of sesame (Sesamum indicum L.) seeds, discovered in the Thousand Buddha Grottoes at Boziklik, Turpan, China, dating to ca. 700 years before present (BP), is hard evidence of their use in China since that time. Morphological and anatomical features suggest a white sesame cultivar. The sizeable quantity unearthed implies that sesame was a valued commodity that could provision the monks and enrich the diet of ancient inhabitants as an oil source.