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Mei‐Mei Li Bo‐Liao Li Shi‐Xiong Jiang Yu‐Wan Zhao Xiang‐Li Xu Jun‐Xiang Wu 《Ecology and evolution》2019,9(23):13426-13437
The oriental armyworm, Mythimna separata, is a serious agricultural pest in China. Seasonal and roundtrip migration has recently led to sudden, localized outbreaks and crop losses. To evaluate genetic differentiation between populations in eastern and western China and elucidate gene flow, the genetic structure of 20 natural populations from nine provinces was examined using seven microsatellite markers. The results indicated high genetic diversity. However, little to moderate (0 < FST < 0.15) genetic differentiation was detected, and there was no correlation between genetic distance and geographical distance. Bayesian clustering analysis identified three groups whereas discriminant analysis of principal components identified ten clusters that were considered as two clear‐cut clusters and one admixed group. Gene flow occurred frequently in most population pairs, and an asymmetrical migration rate was detected in several pairwise population comparisons. The bottleneck test showed that few populations had experienced recent bottlenecks. Correspondingly, large‐scale and long‐distance migration of M. separata has caused low genetic differentiation and frequent gene exchange. Our findings are important for studying genetic evolution and help to improve predictions of M. separata outbreaks in China. 相似文献
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Linda Hoshan Rubin Jiang Joseph Moroney Ashley Bui Xiaolin Zhang Ta-Chun Hang Sen Xu 《Biotechnology progress》2019,35(1):e2743
pH control is critical in bioreactor operations, typically realized through a two-sided control loop, where CO2 sparging and base addition are used in bicarbonate-buffered media. Though a common approach, base addition could compromise culture performance due to the potential impact from pH excursions and osmolality increase in large-scale bioreactors. In this study, the feasibility of utilizing control of sparge gas composition as part of the pH control loop was assessed in Chinese hamster ovary (CHO) fed-batch cultures. Fine pH control was evaluated in multiple processes at different setpoints in small-scale ambr®250 bioreactors. Desired culture pH setpoints were successfully maintained via air sparge feedback control. As part of the pH control loop, air sparging was increased to improve CO2 removal automatically, hence increase culture pH, and vice versa. The effectiveness of this pH control strategy was seamlessly transferred from ambr®250 to 200 L scale, demonstrating scalability of the proposed methodology. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 35: e2743, 2019 相似文献
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Yang Siyuan Xu Weizhi Liu Cheng Jin Jiaqi Li Xueying Jiang Yuhan Zhang Lei Meng Xianbin Zhan Jun Zhang Hongquan 《中国科学:生命科学英文版》2022,65(1):129-141
Science China Life Sciences - Large tumor suppressor 1 (LATS1) is the key kinase controlling activation of Hippo signalling pathway. Post-translational modifications of LATS1 modulate its kinase... 相似文献
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Zhu Yaling Zhou Zhimin Huang Tao Zhang Zhen Li Wanbo Ling Ziqi Jiang Tao Yang Jiawen Yang Siyu Xiao Yanyuan Charlier Carole Georges Michel Yang Bin Huang Lusheng 《中国科学:生命科学英文版》2022,65(8):1517-1534
Science China Life Sciences - The limited knowledge of genomic noncoding and regulatory regions has restricted our ability to decipher the genetic mechanisms underlying complex traits in pigs. In... 相似文献
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Li Guoli Su Bingqian Fu Pengfei Bai Yilin Ding Guangxu Li Dahua Wang Jiang Yang Guoyu Chu Beibei 《中国科学:生命科学英文版》2022,65(2):341-361
Science China Life Sciences - Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread. Therefore, the identification of lipids and metabolic... 相似文献