全文获取类型
收费全文 | 382165篇 |
免费 | 26668篇 |
国内免费 | 1147篇 |
专业分类
409980篇 |
出版年
2018年 | 14849篇 |
2017年 | 13679篇 |
2016年 | 11534篇 |
2015年 | 5164篇 |
2014年 | 6006篇 |
2013年 | 8894篇 |
2012年 | 14453篇 |
2011年 | 23714篇 |
2010年 | 18661篇 |
2009年 | 13863篇 |
2008年 | 19158篇 |
2007年 | 20906篇 |
2006年 | 9892篇 |
2005年 | 9599篇 |
2004年 | 9806篇 |
2003年 | 9515篇 |
2002年 | 9137篇 |
2001年 | 13685篇 |
2000年 | 13718篇 |
1999年 | 10079篇 |
1998年 | 3213篇 |
1997年 | 3174篇 |
1996年 | 3178篇 |
1995年 | 2925篇 |
1994年 | 2887篇 |
1993年 | 2769篇 |
1992年 | 7604篇 |
1991年 | 7359篇 |
1990年 | 7404篇 |
1989年 | 7165篇 |
1988年 | 6662篇 |
1987年 | 6328篇 |
1986年 | 5607篇 |
1985年 | 6018篇 |
1984年 | 4875篇 |
1983年 | 4262篇 |
1982年 | 3014篇 |
1981年 | 2832篇 |
1980年 | 2608篇 |
1979年 | 4394篇 |
1978年 | 3433篇 |
1977年 | 3157篇 |
1976年 | 3094篇 |
1975年 | 3578篇 |
1974年 | 3730篇 |
1973年 | 3748篇 |
1972年 | 3445篇 |
1971年 | 3270篇 |
1970年 | 2665篇 |
1969年 | 2424篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
941.
942.
Regulation of natural killer cell activity by macrophages in the rheumatoid joint and peripheral blood 总被引:3,自引:0,他引:3
B Combe R Pope B Darnell W Kincaid N Talal 《Journal of immunology (Baltimore, Md. : 1950)》1984,133(2):709-713
Recently, in another study, we observed that indomethacin, a prostaglandin synthetase inhibitor, significantly increased NK activity in both normal and rheumatoid arthritis (RA) peripheral blood (PB) but not in RA synovial fluid (SF). Because macrophages are a major source of prostaglandins, we examined the effect of macrophage-enriched adherent cells (AC) on NK activity as measured by a 3-hr Cr-release assay with K 562 cells. The removal of AC resulted in increased (p less than 0.01) NK activity in both normal and RA PB. In contrast, the removal of AC from RA SF resulted in a significant decrease (p less than 0.001) of NK activity. By using only nonadherent cells (NAC), NK activity in RA SF and synovial tissue (ST) was significantly reduced when compared to autologous RA PB (p less than 0.001). Enhancement of NK activity of SF NAC by both poly I:C and IL 2 was not dependent on AC. Mixing experiments demonstrated that the addition of synovial AC for 16 hr increased NK activity of synovial NAC to a level similar to that of unseparated mononuclear cells, whereas autologous PB AC suppressed NK activity of PB NAC. PB AC, when added to SF NAC, also increased NK activity. Supernatants from synovial mononuclear cells were stimulatory of synovial NAC NK activity, whereas normal PB mononuclear supernatants were suppressive. These observations document 1) a significant reduction of NAC-mediated NK activity in the rheumatoid joint as compared to PB from the same patient, and 2) that AC modulate NK activity differently in the rheumatoid joint as compared to RA or normal PB. 相似文献
943.
The effects of dispersal limitation and topographic heterogeneity on beta diversity and phylobetadiversity in a subtropical forest 总被引:1,自引:0,他引:1
Yue Bin Zhigao Wang Zhangming Wang Wanhui Ye Honglin Cao Juyu Lian 《Plant Ecology》2010,209(2):237-256
We assessed the effects of topographic heterogeneity and stem density on species composition between grains of different sizes
(20 × 20, 50 × 50, and 100 × 100 m), based on partial Mantel tests. Similarity in species composition was measured by the
abundance-based Jaccard index (C_J) and by an index that incorporates phylogenetic information into C_J (pC_J). Plants were
divided into five groups, arbor, subarbor, and shrub according to life form and two other groups: species that produce dry
fruits (PDF) and that produce fleshy fruits (PFF). C_J and pC_J between any two grains at each grain size were calculated
separately for these groups and for all species combined. In order to examine what influences C_J and pC_J, we analyzed their
correlations with topographic heterogeneity variables and two dispersal limitation-related variables (stem and topographic
resistance). Our data indicate that at all three grain sizes, C_J and pC_J decrease with increasing distance for all plant
groups. Dispersal limitation and topographic heterogeneity were both important at 20 × 20 and 50 × 50 m grain sizes for C_J
and pC_J of all plant groups; and at 100 × 100 m grain size, topographic heterogeneity dominates over dispersal limitation
for some plant groups. C_J and pC_J of PDFs are less negatively correlated with stem resistance than those of PFFs. We conclude
that both beta diversity and phylobetadiversity are dependent on plant groups and grain sizes. 相似文献
944.
N. E. Belyaeva V. Z. Pashchenko G. Renger G. Yu. Riznichenko A. B. Rubin 《Biophysics》2006,51(6):860-872
A mathematical model of photosystem II (PSII) events was used to analyze chlorophyll fluorescence transients in the time domain from 100 ns to 10 s after excitation with a saturating 10-ns flash, applied as a part of specialized illumination protocol, using preparations of a thermophilic strain of the unicellular green alga, Chlorella pyrenoidosa Chick (using both intact and diuron-treated cells). Analysis of simulation results has proven that particular attention should be given to flash-induced recombination processes, including nonradiative recombination in PSII, while subsequent charge transfer along the electron transport chain of thylakoid membrane can be adequately described by a single reaction of quinone reoxidation. The PSII model was extended by taking inhibition by diuron of the electron transport in the acceptor side of PSII into account, which allowed simulation of fluorescence induction curves observed in the presence of this inhibitor. The model parameters were determined (stromal pH, rate constants of nonradiative recombination, and the initial reduction state of the quinone pool) which provided adequate simulation of experimentally observed ratios of the maximal and initial fluorescence levels (F m/F 0). 相似文献
945.
Jeffrey P Mower Pascal Touzet Julie S Gummow Lynda F Delph Jeffrey D Palmer 《BMC evolutionary biology》2007,7(1):135
Background
It has long been known that rates of synonymous substitutions are unusually low in mitochondrial genes of flowering and other land plants. Although two dramatic exceptions to this pattern have recently been reported, it is unclear how often major increases in substitution rates occur during plant mitochondrial evolution and what the overall magnitude of substitution rate variation is across plants. 相似文献946.
The enlarged inhalant siphon of Fungiacava eilatensis opens into the coelenteron of species of fungiid corals with which it lives in commensal association. Material consisting of mucus, zooxanthellae, nematocysts, plankton and inorganic matter, is taken exclusively from the coelenteron. The very mobile foot possibly assists in food collection and in the removal of pseudofaeces; but, with large ctenidia, the bivalve is a typical ciliary feeder. Experiments with labelled zooxanthellae reveal that these are taken into the gut of Fungiacava with subsequent metabolic incorporation of products derived from them. The other prime source of food must be phytoplankton carried in with the feeding currents of the coral, itself carnivorous so that there is no competition for food between commensal and host. The Fungia zooxanthella– Fungiacava association operates as a "Troika" the productivity of which is autoregulated in proportion to the number of bivalves present. The inorganic wastes of the bivalve (as well as those of the coral) are utilized by the zooxanthellae, resultant increase in the algal component becoming available as food to the bivalve. Losses in the cycle are balanced by intake of exogenous food. 相似文献
947.
948.
949.
950.