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Antisense therapy of hepatitis B virus infection 总被引:2,自引:0,他引:2
Wolf-Bernhard Offensperger Silke Offensperger Hubert E. Blum 《Molecular biotechnology》1998,9(2):161-170
Chronic infection with the hepatitis B virus (HBV) is a major health problem worldwide. The only established therapy is interferon-a
with an efficacy of only 30–40% in highly selected patients. The discovery of animal viruses closely related to the HBV has
contributed to active research on antiviral therapy of chronic hepatitis B. The animal model tested and described in this
article are Peking ducks infected with the duck hepatitis B virus (DHBV). Molecular therapeutic strategies aimed at blocking
gene expression include antisense DNA. An antisense oligodeoxynucleotide directed against the 5′-region of the preS gene of
DHBV inhibited viral replication and gene expression in vitro in primary duck hepatocytes and in vivo in Peking ducks. These
results demonstrate the potential clinical use of antisense DNA as antiviral therapeutics. 相似文献