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Anna Majewska Witold Lasek Mariola Kuczer Grażyna Młynarczyk 《International journal of peptide research and therapeutics》2016,22(2):255-261
Over the past two decades there has been intense study of compounds from vertebrates, microorganisms, plants, mushrooms, marine sponges, worms, etc. as well as insects in terms of their antiviral activity. Insects produce a variety of biologically active peptides. One of them is alloferon. The in vitro and in vivo experiments demonstrate that synthetic alloferon has an immunomodulatory properties. It was reported that alloferon and its analogues (alloferon I and II) have antimicrobial properties, as well. The aim of this study was to evaluate in vitro the effect of alloferon I and II, either alone or in combination with human lymphocytes, on human herpesvirus type 1 (HHV-1) McIntyre strain replication. On the base of results we can conclude that alloferon I and II inhibit the replication of HHV-1 McIntyre strain in HEp-2 cells. Enhanced antiviral activity was observed when infected cells were treated with alloferons and unstimulated or phytohemagglutinin PHA-stimulated lymphocytes simultaneously. After application of alloferons and PHA-stimulated lymphocytes to the HHV-1 infected HEp-2 culture, the mean HHV-1 titer reduction for alloferon and II, when used at the highest dose—400 µg/mL, were 3.69 and 3.27 log10/TCID50/mL, respectively. 相似文献
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Iwona Janczarek Witold Kędzierski 《Journal of applied animal welfare science : JAAWS》2013,16(3):211-219
This study compared the physiological response to novel situations in sex-separated and sex-mixed groups of horses, as measured by heart rate (HR). The study evaluated the possibility of training horses in a mixed-sex system. The study included 41 Purebred Arabian 2½-year-olds during their first walk on an automated horse walker. Four groups, divided by manner of care and training, consisted of 10 colts and 10 fillies kept in separate stables and trained in separate male or female groups and 12 colts and 9 fillies kept in the same stable and trained together. The study measured HR when horses were at rest before exercise, while moving from stable to walker, during 30 min of exercise on walker, while moving from walker to stable, and at rest after exercise. Mean HR scores recorded from training on the walker were higher in sex-mixed groups. Results obtained while horses were moving from stable to walker, then from walker to stable, were significantly higher in the sex-mixed groups. The study did not recommend training young horses in sex-mixed groups. 相似文献
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Witold L. Klawe 《Ocean Development & International Law》2013,44(1):37-64
Abstract Annual catches of pelagic organisms, excluding marine mammals, from the Atlantic and Pacific waters surrounding the Americas for the period 1969–1971 averaged 17, 000, 000 metric tons. Catches of the pelagic organisms from the Pacific alone were nearly 14, 000, 000 tons. However, considering the recent drop in the catches of the Peruvian anchovy, the data for 1972 and 1973 when compiled, will show a drastic decline in the catches of pelagic species. Catches from American waters are compared with those from other waters and their relationship to the area and population of the Americas is examined. The potential maximum catch of pelagic organisms currently utilized is projected to 26, 000, 000 tons, whereas if the markets and fishing technology could be developed for non‐conventional species, then it is estimated that the catch could be increased to 42, 000, 000 tons. Rational utilization of the pelagic resources of the Americas necessitates conservational and managerial measures. This in turn calls for international agreements and/or other international arrangements. This paper was presented at the Inter‐American meeting on “Science and Man in the Americas”; in 1973 at Mexico City. 相似文献
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