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J Erlichman R Gutierrez-Juarez S Zucker X Mei G A Orr 《European journal of biochemistry》1999,263(3):797-805
The coordinated interaction of kinases, phosphatases and other regulatory molecules with scaffolding proteins is emerging as a major theme in intracellular signaling networks. In this report we show that a cDNA isolated from a rat testis expression library by interactive cloning using the regulatory subunit (R) of a type-II protein kinase A (PKA) is identical with a previously characterized protein kinase C (PKC)-binding protein termed either clone 72 [Chapline, C., Mousseau, B., Ramsay, K., Duddy, S., Li, Y., Kiley, S. C. & Jaken, S. (1996) J. Biol. Chem. 271, 6417-6422] or SSeCKS [Lin, X., Tombler, E., B., Nelson, P.J., Ross, M. & Gelman, I.H. (1996) J. Biol. Chem. 271, 28430-28438]. Deletion mutagenesis demonstrated that amino acids 1495-1524 of clone 72/SSeCKS had the ability to interact with RII. Antibodies prepared against the recombinant protein recognized a 280/290-kDa doublet and a 240-kDa protein on Western blots of rat testis cytosolic and Triton X-100 extracts. Expression of clone 72/SSeCKS mRNA and protein levels was developmentally regulated in rat testis. Northern-blot analysis showed a dramatic increase in clone 72/SSeCKS-hybridizing mRNA starting 30 days after birth. Immunohistochemical examination showed high expression levels in elongating spermatids. Clone 72/SSeCKS was not detected in mature sperm. These studies suggest a role for clone 72/SSeCKS, a PKA/PKC scaffolding protein, during the process of spermiogenesis. 相似文献
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176.
Kevin A. Jernigan Olga S. Belichenko Valeria B. Kolosova Darlene J. Orr 《Journal of ethnobiology and ethnomedicine》2017,13(1):61
Background
This study focuses on health-related plant use among speakers of the critically endangered Naukan language (Inuit-Yupik-Unangan family) in the Russian Far East. The Naukan people were forced, in 1958, under Soviet consolidation, to move from their original settlement on Cape Dezhnev, leading to significant changes in spiritual worldview, subsistence, social structure, and language proficiency in the years that followed. Here, we focus on changes that elders report in their edible, medicinal, and spiritual uses of local plant species since their childhood.Methods
The authors worked from 2014 to 2016 in the villages of Lavrentiya, Lorino, and Uelen, in the Chukotskiy district of the Chukotka autonomous region, directly adjacent to the Bering Strait. We conducted structured interviews, using an oral history approach, along with participant observation and collection of voucher specimens from the local arctic tundra. Those with Naukan names and uses represent 42 species in 25 families.Results
Participants reported a decrease of 13% in the number of edible species that people currently harvest, from what they recall harvesting in their youth. On the other hand, the number of local species considered to be medicinal has actually increased by 225%. Current and past Naukan medicinal practices diverge in some notable ways from those of neighboring societies on the Alaskan side of the Bering Strait. Most of the spiritual significance of local plants species is remembered by only a few elders.Conclusions
Naukan elders explained the large increase in use of medicinal plants by noting that their original concept of medicine emphasized prevention and that illnesses were often assigned a spiritual rather than physical cause. Increased integration with ethnic Russians after moving from Naukan led to the adoption not only of new plant uses, but also of an entirely different, more naturalistic way of viewing illness and treatment.177.
Kidd BA Ho PP Sharpe O Zhao X Tomooka BH Kanter JL Steinman L Robinson WH 《Arthritis research & therapy》2008,10(5):R119
Introduction
Anti-citrullinated protein antibodies have a diagnostic role in rheumatoid arthritis (RA); however, little is known about their origins and contribution to pathogenesis. Citrullination is the post-translational conversion of arginine to citrulline by peptidyl arginine deiminase, and increased citrullination of proteins is observed in the joint tissue in RA and in brain tissue in multiple sclerosis (MS). 相似文献178.
Rune Dietz Mads Peter Heide-Jørgensen Pierre Richard Jack Orr Kristin Laidre Hans Christian Schmidt 《Polar Biology》2008,31(11):1295-1306
Twenty-one narwhals tagged in 2003 and 2004 in Admiralty Inlet showed a different summer distributional pattern than previous
narwhal-tracking studies from Somerset Island, Eclipse Sound and Melville Bay. The migration of the narwhals tracked from
Admiralty Inlet moved out through Lancaster Sound 15 days earlier (P < 0.0001) than the narwhals summering around Eclipse Sound, whereas the Admiralty Inlet narwhals reached the mouths of Eclipse
Sound 18 days later (P < 0.0001) than the Eclipse Sound summering population. The winter range of the Admiralty Inlet narwhals overlapped with the
winter range of narwhals from Melville Bay and Eclipse Sound in central southern Baffin Bay and Northern Davis Strait, but
not with the winter range of narwhals from Somerset Island that wintered further north. Distribution size of range, and population
size did not appear to be related. An example of considerable year to year variation between area of summer and winter distribution
in the 2 years was believed to be related to the sample size and number of pods of whales tagged, rather than to differences
in sex or age classes. 相似文献
179.
Transient induced gamma-band response in EEG as a manifestation of miniature saccades 总被引:1,自引:0,他引:1
The induced gamma-band EEG response (iGBR) recorded on the scalp is widely assumed to reflect synchronous neural oscillation associated with object representation, attention, memory, and consciousness. The most commonly reported EEG iGBR is a broadband transient increase in power at the gamma range approximately 200-300 ms following stimulus onset. A conspicuous feature of this iGBR is the trial-to-trial poststimulus latency variability, which has been insufficiently addressed. Here, we show, using single-trial analysis of concomitant EEG and eye tracking, that this iGBR is tightly time locked to the onset of involuntary miniature eye movements and reflects a saccadic "spike potential." The time course of the iGBR is related to an increase in the rate of saccades following a period of poststimulus saccadic inhibition. Thus, whereas neuronal gamma-band oscillations were shown conclusively with other methods, the broadband transient iGBR recorded by scalp EEG reflects properties of miniature saccade dynamics rather than neuronal oscillations. 相似文献
180.
Vincent J. Kalkman Viola Clausnitzer Klaas-Douwe B. Dijkstra Albert G. Orr Dennis R. Paulson Jan van Tol 《Hydrobiologia》2008,595(1):351-363
Larvae of almost all of the 5,680 species of the insect order Odonata (dragonflies and damselflies) are dependent on freshwater
habitats. Both larvae and adults are predators. The order is relatively well studied, and the actual number of species may
be close to 7,000. Many species have small distributional ranges, and are habitat specialists, including inhabitants of alpine
mountain bogs, seepage areas in tropical rain forests, and waterfalls. They are often successfully used as indicators for
environmental health and conservation management. The highest diversity is found in flowing waters in rain forests of the
tropics, the Oriental and Neotropical regions being the most speciose. This paper discusses diversity, summarises the biogeography
of dragonflies in the different biogeographical regions and gives the total number of species and genera per family per biogeographical
region. Examples are given of areas of particular diversity, in terms of areas of endemism, presence of ancient lineages or
remarkable recent radiations but no well-based review of areas with high endemism of dragonflies is available so far. The
conservation status of dragonflies is briefly discussed. Species confined to small remnants of forest in the tropics are most
under threat of extinction by human activities.
Guest editors: E. V. Balian, C. Lévêque, H. Segers and K. Martens
Freshwater Animal Diversity Assessment 相似文献